{
  "id": 23968,
  "label": "ALS2-related motor neuron disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100227",
  "properties": {
    "xrefs": [
      "GARD:0026088"
    ],
    "synonyms": [
      "Alsin-related motor neuron disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Any motor neuron disease in which the cause of the disease is a mutation in the ALS2 gene."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 21302,
      "label": "hereditary motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19749,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019478",
          "MEDGEN:78728",
          "Orphanet:98505",
          "SCTID:49793008",
          "UMLS:C0270763"
        ],
        "synonyms": [
          "genetic anterior horn cell disease",
          "genetic motor neuron disease",
          "hereditary motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of motor neuron disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 27,
      "reference_id": "MONDO:0024257"
    }
  ],
  "children": [
    {
      "id": 10052,
      "label": "amyotrophic lateral sclerosis type 2, juvenile",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17873,
        23968
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060194",
          "GARD:0015137",
          "MEDGEN:349246",
          "MESH:C565957",
          "OMIM:205100",
          "UMLS:C1859807"
        ],
        "synonyms": [
          "ALS2",
          "ALS2 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 2, juvenile",
          "amyotrophic lateral sclerosis caused by mutation in ALS2",
          "ALS, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ALS2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008780"
    },
    {
      "id": 12755,
      "label": "juvenile primary lateral sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        18300,
        23968
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004485",
          "MEDGEN:342870",
          "MESH:C536416",
          "OMIM:606353",
          "Orphanet:247604",
          "SCTID:717964007",
          "UMLS:C1853396"
        ],
        "synonyms": [
          "JPLS",
          "juvenile PLS",
          "PLS juvenile",
          "PLSJ",
          "Pls, juvenile",
          "primary lateral sclerosis, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Juvenile primary lateral sclerosis (JPLS) is a very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011663"
    },
    {
      "id": 12879,
      "label": "infantile-onset ascending hereditary spastic paralysis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        23968
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004914",
          "ICD9:343.8",
          "MEDGEN:419413",
          "MESH:C537217",
          "OMIM:607225",
          "Orphanet:293168",
          "SCTID:703543005",
          "UMLS:C2931441"
        ],
        "synonyms": [
          "IAHSP",
          "spastic paralysis, infantile onset ascending",
          "spastic paralysis, infantile-onset ascending"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a very rare motor neuron disease characterized by severe spasticity of the lower limbs in early life, progression of spasticity to the upper limbs in late childhood, and dysarthria."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011797"
    }
  ],
  "roots": [
    {
      "id": 21302,
      "label": "hereditary motor neuron disease"
    }
  ]
}