{
  "id": 24071,
  "label": "malignant glioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100342",
  "properties": {
    "xrefs": [
      "DOID:3070",
      "GARD:0026148",
      "ICDO:9380/3",
      "MEDGEN:107826",
      "MedDRA:10018338",
      "NCIT:C4822",
      "UMLS:C0555198"
    ],
    "synonyms": [
      "glioma",
      "neuroglial tumor",
      "neuroglial tumour",
      "glial cell tumour",
      "glioma, malignant",
      "high grade glioma",
      "high-grade glioma",
      "malignant glial neoplasm",
      "malignant glial tumor",
      "malignant glial tumour",
      "malignant glioma",
      "malignant neuroglial neoplasm",
      "malignant neuroglial tumor",
      "malignant neuroglial tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 20078,
      "label": "high grade malignant neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:234350",
          "NCIT:C36046",
          "UMLS:C1334017"
        ],
        "synonyms": [
          "high grade malignant neoplasm"
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0020665"
    },
    {
      "id": 20287,
      "label": "glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005543",
          "GARD:0006513",
          "MEDGEN:9030",
          "MESH:D005910",
          "NCIT:C3059",
          "Orphanet:182067",
          "SCTID:393564001",
          "UMLS:C0017638"
        ],
        "synonyms": [
          "glial neoplasm",
          "glial tumor",
          "glial tumour",
          "glioma",
          "neoplasm of neuroglia",
          "neoplasm of the neuroglia",
          "neuroglial neoplasm",
          "neuroglial tumor",
          "neuroglial tumour",
          "tumor of neuroglia",
          "tumor of the neuroglia",
          "tumour of neuroglia",
          "tumour of the neuroglia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0021042"
    }
  ],
  "children": [
    {
      "id": 4608,
      "label": "spinal cord glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5449,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3185",
          "GARD:0023158",
          "MEDGEN:423646",
          "NCIT:C4534",
          "SCTID:254946004",
          "UMLS:C2937245"
        ],
        "synonyms": [
          "glial neoplasm spinal cord",
          "glial tumor of spinal cord",
          "glial tumour of spinal cord",
          "malignant glioma of spinal cord",
          "spinal cord glial neoplasm",
          "spinal cord glial tumor",
          "spinal cord glial tumour",
          "spinal cord glioma",
          "spinal cord malignant glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm that arises from glial cells in the spinal cord. Representative examples include astrocytoma, oligodendroglioma, and ependymoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002542"
    },
    {
      "id": 5197,
      "label": "granular cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7788,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5042",
          "GARD:0023423",
          "ICD9:171.9",
          "ICDO:9580/3",
          "MEDGEN:87276",
          "NCIT:C4336",
          "SCTID:404041003",
          "UMLS:C0334618"
        ],
        "synonyms": [
          "granular cell tumor, malignant",
          "granular cell tumor, malignant (morphologic abnormality)",
          "malignant granular cell myoblastoma",
          "malignant granular cell neoplasm",
          "malignant granular cell tumor",
          "malignant granular cell tumour",
          "myoblastoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An uncommon granular cell tumor which may metastasize to other anatomic sites. Morphologic characteristics include the presence of spindling neoplastic cells, necrosis, extensive pleomorphism, prominent nucleoli, and increased mitiotic activity."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003252"
    },
    {
      "id": 5244,
      "label": "neurofibroma of gallbladder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7085,
        17201,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5150",
          "GARD:0023438",
          "MEDGEN:232540",
          "NCIT:C5746",
          "UMLS:C1333751"
        ],
        "synonyms": [
          "gall bladder neurofibroma",
          "gallbladder neurofibroma",
          "neurofibroma of gall bladder",
          "neurofibroma of gallbladder",
          "neurofibroma of the gallbladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A non-metastasizing encapsulated neoplasm arising from nerves in the gallbladder. Morphologically, it is characterized by the presence of fibroblasts and Schwann cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003303"
    },
    {
      "id": 6523,
      "label": "neurofibroma of the heart",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3568,
        17201,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9300",
          "GARD:0024101",
          "MEDGEN:242755",
          "NCIT:C5359",
          "UMLS:C1096349"
        ],
        "synonyms": [
          "Cardiac neurofibroma",
          "heart neurofibroma",
          "neurofibroma of heart",
          "neurofibroma of the heart"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare neurofibroma that affects the heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004752"
    },
    {
      "id": 7155,
      "label": "brain glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060108",
          "GARD:0024195",
          "MEDGEN:91163",
          "NCIT:C162993",
          "SCTID:254937005",
          "UMLS:C0349661"
        ],
        "synonyms": [
          "brain malignant glioma",
          "malignant glioma of brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant glioma that involves the brain."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005499"
    },
    {
      "id": 17144,
      "label": "high grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020704",
          "MEDGEN:769639",
          "NCIT:C102897",
          "Orphanet:251561",
          "UMLS:C3640999"
        ],
        "synonyms": [
          "high grade astrocytic neoplasm",
          "high grade astrocytic tumor",
          "high-grade astrocytic neoplasm",
          "high-grade astrocytic tumor",
          "high-grade astrocytic tumour",
          "high-grade astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016680"
    },
    {
      "id": 17199,
      "label": "malignant perineurioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19233,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020741",
          "ICDO:9571/3",
          "MEDGEN:220432",
          "NCIT:C66845",
          "Orphanet:252128",
          "SCTID:761958009",
          "UMLS:C1266188",
          "icd11.foundation:986576766"
        ],
        "synonyms": [
          "malignant peripheral nerve sheath tumor with perineurial differentiation",
          "malignant peripheral nerve sheath tumour with perineurial differentiation",
          "perineurial malignant peripheral nerve sheath tumor",
          "perineurial malignant peripheral nerve sheath tumour",
          "perineurioma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A very rare malignant tumor with morphologic features similar to those of benign perineurioma of soft tissue along with hypercellularity, nuclear atypia, hyperchromasia, and a high mitotic rate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016751"
    },
    {
      "id": 18046,
      "label": "malignant peripheral nerve sheath tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4336,
        4613,
        17197,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5940",
          "EFO:0000760",
          "GARD:0010872",
          "ICD9:171.9",
          "ICDO:9540/3",
          "ICDO:9560/3",
          "MEDGEN:155614",
          "MedDRA:10029236",
          "NANDO:2200102",
          "NCIT:C3798",
          "ONCOTREE:MPNST",
          "Orphanet:3148",
          "SCTID:404037002",
          "UMLS:C0751690",
          "icd11.foundation:71413945"
        ],
        "synonyms": [
          "neurofibrosarcoma",
          "MPNST",
          "Malig. periph. nerve sheath tum.",
          "malignant neoplasm of peripheral nerve sheath",
          "malignant neurilemmoma",
          "malignant neurilemoma",
          "malignant neurofibroma",
          "malignant peripheral nerve sheath neoplasm",
          "malignant peripheral nerve sheath tumor",
          "malignant peripheral nerve sheath tumor (morphologic abnormality)",
          "malignant peripheral nerve sheath tumor [dup] (morphologic abnormality)",
          "malignant peripheral nerve sheath tumour (morphologic abnormality)",
          "malignant peripheral nerve sheath tumour [dup] (morphologic abnormality)",
          "malignant schwannoma",
          "malignant tumor of peripheral nerve sheath",
          "malignant tumor of the peripheral nerve sheath",
          "malignant tumour of peripheral nerve sheath",
          "malignant tumour of the peripheral nerve sheath",
          "neurofibrosarcoma, malignant",
          "neurogenic sarcoma",
          "schwannoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma occurring in a wide range of anatomical sites."
      },
      "child_count": 35,
      "reference_id": "MONDO:0017827"
    },
    {
      "id": 18713,
      "label": "oligodendroglial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013156",
          "MEDGEN:233266",
          "NCIT:C6960",
          "Orphanet:46484",
          "UMLS:C1335110"
        ],
        "synonyms": [
          "oligodendroglial neoplasm",
          "oligodendroglial tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Oligodendrogliomas are cerebral tumors that are differentiated from other gliomas on the basis of their unique genetic characteristics and better response to chemotherapy. These tumors are classified according to their grade (low grade oligodendrogliomas: grade II of the WHO classification and anaplastic oligodendrogliomas: grade III of the WHO classification) and according to their pure or mixed histology (oligoastrocytomas)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018744"
    },
    {
      "id": 20696,
      "label": "grade III glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025346",
          "MEDGEN:925529",
          "NCIT:C127816",
          "UMLS:C4287997"
        ],
        "synonyms": [
          "WHO grade III glioma",
          "anaplastic glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021640"
    },
    {
      "id": 22804,
      "label": "isolated melanotic schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4336,
        4623,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022368",
          "Orphanet:590539"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035136"
    },
    {
      "id": 26452,
      "label": "pediatric high-grade glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8005,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027222",
          "MEDGEN:1861427",
          "NCIT:C202298",
          "UMLS:C5908419"
        ],
        "synonyms": [
          "childhood malignant glioma",
          "pHGG"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant high-grade glioma that occurs during childhood in the central nervous system."
      },
      "child_count": 2,
      "reference_id": "MONDO:1010030"
    }
  ],
  "roots": [
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 20078,
      "label": "high grade malignant neoplasm"
    },
    {
      "id": 20287,
      "label": "glioma"
    }
  ]
}