{
  "id": 24217,
  "label": "generalized pustular psoriasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100491",
  "properties": {
    "xrefs": [
      "GARD:0026245",
      "ICD10CM:L40.1",
      "MEDGEN:473074",
      "Orphanet:247353",
      "SCTID:238612002",
      "UMLS:C0343055"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A rare and extreme form of psoriasis characterized by the appearance of sterile pustules which can take many patterns. All the main pathological features of the disease are accentuated. Generalized pustular psoriasis is clinically heterogeneous in its age at onset, precipitants, severity, and natural history. Many overlapping clinical entities are recognized. There is a relationship between these entities and plaque psoriasis, as some individuals may have episodes of plaque psoriasis preceding or following the generalized pustular psoriasis, but in others generalized pustular psoriasis occurs as the sole phenotype without plaque psoriasis at any time."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 20830,
      "label": "pustular psoriasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6811
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:696.1",
          "MEDGEN:508876",
          "NANDO:1200240",
          "NANDO:2100285",
          "NANDO:2201001",
          "SCTID:200973000",
          "UMLS:C0152081",
          "icd11.foundation:64081271"
        ],
        "synonyms": [
          "pustular psoriasis",
          "Pustular psoriasis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0022205"
    }
  ],
  "children": [
    {
      "id": 14651,
      "label": "psoriasis 14, pustular",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19129,
        19503,
        21247,
        24217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080474",
          "GARD:0017679",
          "ICD9:696.1",
          "MEDGEN:581114",
          "NANDO:1200244",
          "NANDO:2200452",
          "NCIT:C119057",
          "OMIM:614204",
          "Orphanet:163931",
          "Orphanet:404546",
          "SCTID:83839005",
          "UMLS:C0392439"
        ],
        "synonyms": [
          "palmoplantar pustulosis",
          "DITRA",
          "IL36RN psoriasis",
          "Interleukin 36 receptor antagonist deficiency",
          "PSORP",
          "PSORS14",
          "acrodermatitis continua of Hallopeau",
          "acrodermatitis continua suppurativa of Hallopeau",
          "deficiency of IL-36R antagonist",
          "deficiency of IL-36Ra",
          "deficiency of the interleukin-36 receptor antagonist",
          "familial generalised pustular psoriasis",
          "psoriasis 14, pustular",
          "psoriasis caused by mutation in IL36RN",
          "GPP",
          "generalised pustular psoriasis",
          "generalized pustular psoriasis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Any psoriasis in which the cause of the disease is a mutation in the IL36RN gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013626"
    }
  ],
  "roots": [
    {
      "id": 20830,
      "label": "pustular psoriasis"
    }
  ]
}