{
  "id": 24267,
  "label": "clonal hematopoiesis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0100542",
  "properties": {
    "xrefs": [
      "GARD:0026272",
      "MEDGEN:1694554",
      "NCIT:C162188",
      "UMLS:C5206406"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A precancerous condition characterized by cellular proliferation of hematopoietic cells where a substantial proportion of the cells are derived from a single hematopoietic stem cell lineage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 23758,
      "label": "premalignant hematological system disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217,
        20315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026011",
          "MEDGEN:233342",
          "NCIT:C27274",
          "UMLS:C1335471"
        ],
        "synonyms": [
          "premalignant hematologic condition"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hematologic disorder which does not display the morphologic and/or clinical characteristics of an overt malignancy. Representative examples include atypical lymphoproliferative disorders and myelodysplastic syndromes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0060782"
    }
  ],
  "children": [
    {
      "id": 24268,
      "label": "clonal hematopoiesis of indeterminate potential",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24267
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026273",
          "MEDGEN:1681237",
          "UMLS:C4761612"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A precancerous condition characterized by the presence of somatic mutations in bone marrow or peripheral blood cells in individuals who may be cytopenic but do not have morphologic evidence of hematologic neoplasia. Its prevalence rises with age and is found in approximately 10% of individuals aged 70 to 80. It is associated with an increased risk of hematologic neoplasia. Mutations in the DNMT3A, TET2, or ASXL1 genes are usually identified. Approximately 10%-40% of individuals with age-related clonal hematopoiesis will progress to meet the diagnostic criteria for clonal hematopoiesis of indeterminate potential."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100543"
    },
    {
      "id": 24269,
      "label": "age-related clonal hematopoiesis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24267
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026274",
          "MEDGEN:1670618",
          "UMLS:C4722404"
        ],
        "synonyms": [
          "ARCH"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A precancerous condition characterized by the gradual, clonal expansion of hematopoietic stem and progenitor cells carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. It is associated with an increased risk of developing hematologic cancers."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100544"
    }
  ],
  "roots": [
    {
      "id": 23758,
      "label": "premalignant hematological system disease"
    }
  ]
}