{
  "id": 24387,
  "label": "acinar dysplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0600016",
  "properties": {
    "xrefs": [
      "GARD:0026297",
      "MEDGEN:835348",
      "UMLS:C3872820",
      "icd11.foundation:1890124170"
    ],
    "synonyms": [
      "AcDys"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A lethal, developmental lung malformation resulting in neonatal respiratory insufficiency. It is characterized by pulmonary hypoplasia and arrest in the pseudoglandular stage of development, resulting in the absence of functional gas exchange. It can be caused by mutations in FGF10, FGFR2 or TBX4."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6815,
      "label": "respiratory system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1579",
          "EFO:0000684",
          "ICD10CM:J00-J99",
          "ICD9:460-519",
          "ICD9:500-508",
          "ICD9:503",
          "ICD9:508",
          "ICD9:508.1",
          "ICD9:508.8",
          "ICD9:508.9",
          "ICD9:510-519",
          "ICD9:516",
          "ICD9:516.8",
          "ICD9:516.9",
          "ICD9:517",
          "ICD9:517.8",
          "ICD9:519",
          "ICD9:519.1",
          "ICD9:519.3",
          "ICD9:519.8",
          "ICD9:519.9",
          "ICD9:V12.60",
          "ICD9:V47.2",
          "MEDGEN:48421",
          "MESH:D012140",
          "NANDO:1100010",
          "NCIT:C26871",
          "SCTID:50043002",
          "UMLS:C0035204"
        ],
        "synonyms": [
          "disease of respiratory system",
          "disease or disorder of respiratory system",
          "disorder of respiratory system",
          "respiratory disease",
          "respiratory disorder",
          "respiratory system disease",
          "respiratory system disease or disorder",
          "respiratory system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma."
      },
      "child_count": 59,
      "reference_id": "MONDO:0005087"
    }
  ],
  "children": [
    {
      "id": 24388,
      "label": "acinar dysplasia caused by mutation in FGF10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        24387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026298"
        ],
        "synonyms": [
          "FGF10 acinar dysplasia",
          "FGF10 related acinar dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Any acinar dysplasia in which the cause of the disease is a mutation in the FGF10 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0600017"
    },
    {
      "id": 24389,
      "label": "acinar dysplasia caused by mutation in FGFR2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        24387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026299"
        ],
        "synonyms": [
          "FGFR2 acinar dysplasia",
          "FGFR2 related acinar dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Any acinar dysplasia in which the cause of the disease is a mutation in the FGFR2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0600018"
    },
    {
      "id": 24390,
      "label": "acinar dysplasia caused by mutation in TBX4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        24387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026300"
        ],
        "synonyms": [
          "TBX4 acinar dysplasia",
          "TBX4 related acinar dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Any acinar dysplasia in which the cause of the disease is a mutation in the TBX4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0600019"
    }
  ],
  "roots": [
    {
      "id": 6815,
      "label": "respiratory system disorder"
    }
  ]
}