{
  "id": 24647,
  "label": "parneoplastic endocrine syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0700252",
  "properties": {
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Paraneoplastic syndrome that involves the endocrine system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6875,
      "label": "endocrine system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:28",
          "EFO:0001379",
          "ICD9:259.8",
          "ICD9:259.9",
          "MEDGEN:4043",
          "MESH:D004700",
          "NANDO:1100009",
          "NANDO:2100109",
          "NCIT:C3009",
          "SCTID:362969004",
          "UMLS:C0014130"
        ],
        "synonyms": [
          "disease of endocrine system",
          "disease or disorder of endocrine system",
          "disorder of endocrine system",
          "endocrine disease",
          "endocrine disorder",
          "endocrine system disease",
          "endocrine system disease or disorder",
          "endocrine system disorder",
          "endocrinopathy",
          "thyroid or other glandular disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the endocrine system."
      },
      "child_count": 48,
      "reference_id": "MONDO:0005151"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        23540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:45320",
          "MESH:D010257",
          "NCIT:C3311",
          "SCTID:49783001",
          "UMLS:C0030472"
        ],
        "synonyms": [
          "paraneoplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021073"
    }
  ],
  "children": [
    {
      "id": 17680,
      "label": "POEMS syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6569,
        16613,
        18348,
        24647,
        24648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14039",
          "EFO:1001115",
          "GARD:0007411",
          "MEDGEN:39276",
          "MESH:D016878",
          "MedDRA:10053869",
          "NANDO:1200033",
          "NCIT:C80303",
          "NORD:1586",
          "Orphanet:2905",
          "SCTID:79268002",
          "UMLS:C0085404",
          "icd11.foundation:1555299114"
        ],
        "synonyms": [
          "Crow-Fukase syndrome",
          "PEP syndrome",
          "POEMS syndrome",
          "Takatsuki syndrome",
          "osteosclerotic myeloma",
          "polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome",
          "polyneuropathy organomegaly",
          "polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017364"
    },
    {
      "id": 18274,
      "label": "Oncogenic osteomalacia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3323,
        24647,
        24650
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009652",
          "MEDGEN:226893",
          "MESH:C537751",
          "NCIT:C67235",
          "Orphanet:352540",
          "SCTID:392559009",
          "UMLS:C1274103"
        ],
        "synonyms": [
          "Oncogenic hypophosphatemic osteomalacia",
          "TIO",
          "tumor-induced osteomalacia",
          "OO",
          "OOM"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Oncogenic osteomalacia is characterized by the development of a tumor that causes the bones to be weakened. This occurs when a tumor secretes a substance called fibroblast growth factor 23 (FGF23). FGF23 inhibits the ability of the kidneys to absorb phosphate. Phosphate is important for keeping bones strong and healthy. Therefore, this disease is characterized by a softening and weakening of the bones (osteomalacia). The disease also results in multiple biochemical abnormalities including high levels of phosphate in the urine (hyperphosphaturia) and low levels of phosphate in the blood (hypophosphatemia). The majority of tumors that cause oncogenic osteomalacia are small and slow-growing. These tumors most commonly occur in the skin, muscles, or bones of the extremities or in the paranasal sinuses around the head. Most of these tumors are benign, meaning they are not associated with cancer. The exact reason that the tumors associated with oncogenic osteomalacia develop is not known. The disease is diagnosed when a person experiences clinical features such as bone weakening and hyperphosphaturia and a tumor is found by imaging of the body. Treatment of the disease consists of surgical removal of the tumor. The symptoms of the disease, including the weakening of the bones, typically resolve once the tumor is removed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018124"
    }
  ],
  "roots": [
    {
      "id": 6875,
      "label": "endocrine system disorder"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome"
    }
  ]
}