{
  "id": 24648,
  "label": "paraneoplastic hematological syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0700253",
  "properties": {
    "xrefs": [
      "GARD:0026398"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Paraneoplastic syndrome that involves the hematopoietic system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7217,
      "label": "hematologic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:74",
          "EFO:0005803",
          "GTR:AN1320635",
          "ICD10CM:D50-D89",
          "ICD9:280-289",
          "ICD9:289.8",
          "ICD9:289.9",
          "MEDGEN:5483",
          "MESH:D006402",
          "NANDO:1100006",
          "NANDO:2100175",
          "NCIT:C26323",
          "Orphanet:97992",
          "SCTID:414022008",
          "UMLS:C0018939"
        ],
        "synonyms": [
          "blood disease",
          "blood disorder",
          "disease of hematopoietic system",
          "disease of the blood and blood-forming organs",
          "disease or disorder of haematopoietic system",
          "disease or disorder of hematopoietic system",
          "disorder of haematopoietic system",
          "disorder of hematopoietic system",
          "haematological disease",
          "haematological disorder",
          "haematological system disease",
          "haematopoietic disease",
          "haematopoietic system disease or disorder",
          "hematologic and lymphocytic disorder",
          "hematologic disorder",
          "hematological disease",
          "hematological disorder",
          "hematological system disease",
          "hematopoietic disease",
          "hematopoietic system disease",
          "hematopoietic system disease or disorder",
          "rare hematologic disease",
          "haematological disorders and malignancies",
          "hematological disorders and malignancies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving the hematopoietic system."
      },
      "child_count": 27,
      "reference_id": "MONDO:0005570"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        23540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:45320",
          "MESH:D010257",
          "NCIT:C3311",
          "SCTID:49783001",
          "UMLS:C0030472"
        ],
        "synonyms": [
          "paraneoplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021073"
    }
  ],
  "children": [
    {
      "id": 17680,
      "label": "POEMS syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6569,
        16613,
        18348,
        24647,
        24648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14039",
          "EFO:1001115",
          "GARD:0007411",
          "MEDGEN:39276",
          "MESH:D016878",
          "MedDRA:10053869",
          "NANDO:1200033",
          "NCIT:C80303",
          "NORD:1586",
          "Orphanet:2905",
          "SCTID:79268002",
          "UMLS:C0085404",
          "icd11.foundation:1555299114"
        ],
        "synonyms": [
          "Crow-Fukase syndrome",
          "PEP syndrome",
          "POEMS syndrome",
          "Takatsuki syndrome",
          "osteosclerotic myeloma",
          "polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome",
          "polyneuropathy organomegaly",
          "polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017364"
    },
    {
      "id": 23210,
      "label": "humoral hypercalcemia of malignancy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3771,
        24648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025860",
          "MEDGEN:56210",
          "MESH:C562390",
          "NCIT:C3496",
          "SCTID:47709007",
          "UMLS:C0149911"
        ],
        "synonyms": [
          "humoral hypercalcemia of malignancy",
          "hypercalcemia of malignancy",
          "hhm",
          "mahc",
          "malignancy associated hypercalcemia",
          "malignant hypercalcemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease. Symptoms include central nervous system impairment such as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043455"
    }
  ],
  "roots": [
    {
      "id": 7217,
      "label": "hematologic disorder"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome"
    }
  ]
}