{
  "id": 24660,
  "label": "paraneoplastic rheumatic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0700265",
  "properties": {
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Paraneoplastic syndrome that involves the joints, bones, muscles, and/or connective tissue."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 20314,
      "label": "paraneoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        23540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:45320",
          "MESH:D010257",
          "NCIT:C3311",
          "SCTID:49783001",
          "UMLS:C0030472"
        ],
        "synonyms": [
          "paraneoplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021073"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 20314,
      "label": "paraneoplastic syndrome"
    }
  ]
}