{
  "id": 24661,
  "label": "paraneoplastic cutaneous syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0700266",
  "properties": {
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Paraneoplastic syndrome that involves the integumental system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4198,
      "label": "integumentary system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:16",
          "EFO:0010285",
          "MEDGEN:712400",
          "SCTID:128598002",
          "UMLS:C1290011"
        ],
        "synonyms": [
          "disease of integumental system",
          "disease or disorder of integumental system",
          "disorder of integumental system",
          "integumental system disease",
          "integumental system disease or disorder",
          "integumentary disease",
          "disorder of integument"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease involving the integumental system."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002051"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        23540
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:45320",
          "MESH:D010257",
          "NCIT:C3311",
          "SCTID:49783001",
          "UMLS:C0030472"
        ],
        "synonyms": [
          "paraneoplastic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021073"
    }
  ],
  "children": [
    {
      "id": 18893,
      "label": "paraneoplastic pemphigus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        19177,
        24661
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080852",
          "EFO:0008602",
          "GARD:0018858",
          "ICD10CM:L10.81",
          "MEDGEN:798302",
          "MedDRA:10057056",
          "NANDO:1200231",
          "Orphanet:63455",
          "UMLS:C1112570",
          "icd11.foundation:104197957"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Pemphigus is a group of chronic autoimmune skin diseases characterized by blisters formation on the outer layer of the skin and the mucous membranes. Three clinical forms have been characterized, of which paraneoplastic pemphigus is extremely rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018974"
    }
  ],
  "roots": [
    {
      "id": 4198,
      "label": "integumentary system disorder"
    },
    {
      "id": 20314,
      "label": "paraneoplastic syndrome"
    }
  ]
}