{
  "id": 24670,
  "label": "prostate cancer, hereditary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0700275",
  "properties": {
    "xrefs": [
      "GARD:0027144",
      "MEDGEN:419810",
      "MESH:C537243",
      "OMIM:176807",
      "Orphanet:1331",
      "SCTID:715412008",
      "UMLS:C2931456"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An instance of prostate cancer that is caused by an inherited genomic modification in an individual. Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 18,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 9621,
      "label": "prostate cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        20463
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10283",
          "ICD10CM:C61",
          "ICD9:185",
          "MEDGEN:138169",
          "MESH:D011471",
          "NCIT:C7378",
          "SCTID:399068003",
          "UMLS:C0376358"
        ],
        "synonyms": [
          "prostate neoplasm",
          "prostatic neoplasm",
          "tumor of the prostate",
          "tumour of the prostate",
          "cancer of prostate gland",
          "malignant neoplasm of prostate",
          "malignant neoplasm of prostate gland",
          "malignant neoplasm of the prostate",
          "malignant prostate gland neoplasm",
          "malignant prostate neoplasm",
          "malignant prostate tumor",
          "malignant prostate tumour",
          "malignant tumor of prostate",
          "malignant tumor of the prostate",
          "malignant tumour of prostate",
          "malignant tumour of the prostate",
          "prostate gland cancer",
          "hereditary prostate cancer",
          "prostate cancer, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0008315"
    }
  ],
  "children": [
    {
      "id": 11431,
      "label": "prostate cancer, hereditary, X-linked 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015253",
          "MEDGEN:339479",
          "OMIM:300147",
          "UMLS:C1846279"
        ],
        "synonyms": [
          "HPCX1",
          "prostate cancer, hereditary, X-linked 1",
          "prostate cancer susceptibility, X-linked"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010257"
    },
    {
      "id": 11566,
      "label": "prostate cancer, hereditary, X-linked 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015260",
          "MEDGEN:394426",
          "MESH:C567477",
          "OMIM:300704",
          "UMLS:C2678047"
        ],
        "synonyms": [
          "HPCX2",
          "prostate cancer, hereditary, X-linked 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010405"
    },
    {
      "id": 12224,
      "label": "prostate cancer, hereditary, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015334",
          "MEDGEN:1648436",
          "OMIM:601518",
          "UMLS:C4722327"
        ],
        "synonyms": [
          "RNASEL familial prostate cancer",
          "familial prostate cancer caused by mutation in RNASEL",
          "prostate cancer 1",
          "prostate cancer, hereditary, 1",
          "prostate cancer, hereditary, type 1",
          "HPC1",
          "Prca1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011098"
    },
    {
      "id": 12390,
      "label": "prostate cancer, hereditary, 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015351",
          "MEDGEN:400539",
          "MESH:C566426",
          "OMIM:602759",
          "UMLS:C1864472"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 8",
          "prostate cancer, hereditary, type 8",
          "HPC8",
          "predisposing for prostate cancer",
          "prostate cancer, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011270"
    },
    {
      "id": 13159,
      "label": "prostate cancer, hereditary, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015439",
          "MEDGEN:373367",
          "MESH:C563883",
          "OMIM:608656",
          "UMLS:C1837595"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 3",
          "prostate cancer, hereditary, type 3",
          "prostate cancer, susceptibility to, 3",
          "HPC3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012093"
    },
    {
      "id": 13160,
      "label": "prostate cancer, hereditary, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015440",
          "MEDGEN:325204",
          "MESH:C563882",
          "OMIM:608658",
          "UMLS:C1837593"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 4",
          "prostate cancer, hereditary, type 4",
          "prostate cancer, susceptibility to, 4",
          "HPC4",
          "prostate cancer, hereditary, on chromosome 7"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012094"
    },
    {
      "id": 13303,
      "label": "prostate cancer, hereditary, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015455",
          "MEDGEN:373085",
          "MESH:C563744",
          "OMIM:609299",
          "UMLS:C1836436"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 5",
          "prostate cancer, hereditary, type 5",
          "HPC5"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012244"
    },
    {
      "id": 13356,
      "label": "prostate cancer, hereditary, 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015462",
          "MEDGEN:322797",
          "MESH:C563699",
          "OMIM:609558",
          "UMLS:C1836005"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 6",
          "prostate cancer, hereditary, type 6",
          "HPC6",
          "prostate cancer, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012300"
    },
    {
      "id": 13519,
      "label": "prostate cancer, hereditary, 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015478",
          "MEDGEN:377849",
          "MESH:C565201",
          "OMIM:610321",
          "UMLS:C1853195"
        ],
        "synonyms": [
          "HPC7",
          "prostate cancer, hereditary, 7",
          "prostate cancer aggressiveness"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012470"
    },
    {
      "id": 13644,
      "label": "prostate cancer, hereditary, 9",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015505",
          "MEDGEN:369689",
          "MESH:C567031",
          "OMIM:610997",
          "UMLS:C1970250"
        ],
        "synonyms": [
          "prostate cancer, hereditary, 9",
          "prostate cancer, hereditary, type 9",
          "HPC9"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012597"
    },
    {
      "id": 13666,
      "label": "prostate cancer, hereditary, 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015507",
          "MEDGEN:370202",
          "MESH:C567011",
          "OMIM:611100",
          "UMLS:C1970192"
        ],
        "synonyms": [
          "HPC10",
          "prostate cancer, hereditary, 10"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012620"
    },
    {
      "id": 13781,
      "label": "prostate cancer, hereditary, 12",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015529",
          "MEDGEN:437216",
          "MESH:C567510",
          "OMIM:611868",
          "UMLS:C2678479"
        ],
        "synonyms": [
          "EHBP1 familial prostate cancer",
          "familial prostate cancer caused by mutation in EHBP1",
          "prostate cancer, hereditary, 12",
          "prostate cancer, hereditary, type 12",
          "HPC12"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012741"
    },
    {
      "id": 13798,
      "label": "prostate cancer, hereditary, 13",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015534",
          "MEDGEN:383198",
          "MESH:C567456",
          "OMIM:611928",
          "UMLS:C2677821"
        ],
        "synonyms": [
          "MSMB familial prostate cancer",
          "familial prostate cancer caused by mutation in MSMB",
          "prostate cancer, hereditary, 13",
          "prostate cancer, hereditary, type 13",
          "HPC13"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012758"
    },
    {
      "id": 13808,
      "label": "prostate cancer, hereditary, 11",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015536",
          "MEDGEN:394363",
          "MESH:C567449",
          "OMIM:611955",
          "UMLS:C2677773"
        ],
        "synonyms": [
          "HPC11",
          "prostate cancer, hereditary, 11"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012768"
    },
    {
      "id": 13809,
      "label": "prostate cancer, hereditary, 14",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015537",
          "MEDGEN:393832",
          "MESH:C567448",
          "OMIM:611958",
          "UMLS:C2677772"
        ],
        "synonyms": [
          "HPC14",
          "prostate cancer, hereditary, 14"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012769"
    },
    {
      "id": 13810,
      "label": "prostate cancer, hereditary, 15",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015538",
          "MEDGEN:437036",
          "MESH:C567447",
          "OMIM:611959",
          "UMLS:C2677771"
        ],
        "synonyms": [
          "HPC15",
          "prostate cancer, hereditary, 15"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012770"
    },
    {
      "id": 14884,
      "label": "prostate cancer, hereditary, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015839",
          "MEDGEN:761328",
          "OMIM:614731",
          "UMLS:C3539120"
        ],
        "synonyms": [
          "ELAC2 familial prostate cancer",
          "familial prostate cancer caused by mutation in ELAC2",
          "prostate cancer, hereditary, 2",
          "prostate cancer, hereditary, 2, susceptibility to",
          "prostate cancer, hereditary, type 2",
          "HPC2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Any familial prostate cancer in which the cause of the disease is a mutation in the ELAC2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013872"
    },
    {
      "id": 21143,
      "label": "familial prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6882,
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004520",
          "GTR:AN0101368",
          "GTR:AN0101369",
          "MEDGEN:1667326",
          "NCIT:C103817",
          "UMLS:C4722328"
        ],
        "synonyms": [
          "hereditary prostate carcinoma",
          "prostate cancer, familial",
          "prostate cancer, hereditary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023122"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 9621,
      "label": "prostate cancer"
    }
  ]
}