{
  "id": 24822,
  "label": "necrotizing vasculitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0800113",
  "properties": {
    "xrefs": [
      "GARD:0005106",
      "MEDGEN:230813",
      "NCIT:C70635",
      "UMLS:C1318520"
    ],
    "synonyms": [
      "systemic vasculitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A type of vasculitis that is comprised of vasculitides that present with necrosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    }
  ],
  "children": [
    {
      "id": 16324,
      "label": "anti-neutrophil cytoplasmic antibody-associated vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013011",
          "MEDGEN:403453",
          "MESH:D056648",
          "Orphanet:156152",
          "UMLS:C2717865",
          "icd11.foundation:1404622826"
        ],
        "synonyms": [
          "AAV",
          "ANCA-associated vasculitis",
          "antineutrophil cytoplasmic antibody-associated vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Group of systemic vasculitis with a strong association with anca. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015492"
    },
    {
      "id": 19042,
      "label": "immunoglobulin A vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8242,
        16323,
        24822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11123",
          "GARD:0008204",
          "ICD10CM:D69.0",
          "ICD9:287.0",
          "MEDGEN:48265",
          "MESH:D011695",
          "NCIT:C34963",
          "Orphanet:761",
          "SCTID:191306005",
          "SCTID:86074002",
          "UMLS:C0034152",
          "icd11.foundation:1629105375"
        ],
        "synonyms": [
          "HSP",
          "IgA vasculitis",
          "Schoenlein-Henoch purpura",
          "allergic purpura",
          "anaphylactoid purpura",
          "purpura rheumatica",
          "rheumatoid purpura",
          "Henoch Schonlein purpura",
          "purpura, Schonlein-Henoch",
          "vascular purpura"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A systemic IgA vasculitis that affects small vessels. It is characterized by skin purpura, arthritis, and abdominal and/or renal involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019167"
    },
    {
      "id": 24831,
      "label": "disseminated visceral giant cell angiitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        24822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026444"
        ],
        "synonyms": [
          "disseminated visceral giant cell arteristic",
          "disseminated visceral giant cell arteritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A necrotizing vasculitis characterized by widespread small-vessel giant cell angitis and extravascular granulomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800125"
    }
  ],
  "roots": [
    {
      "id": 18813,
      "label": "vasculitis"
    }
  ]
}