{
  "id": 24830,
  "label": "Lane Hamilton syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0800124",
  "properties": {
    "xrefs": [
      "GARD:0026443"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A rare concurrent association of idiopathic pulmonary hemosiderosis and celiac disease, and is typically seen in children under the age of 15."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6854,
      "label": "celiac disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        5714,
        20033,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10608",
          "EFO:0001060",
          "ICD10CM:K90.0",
          "ICD9:579.0",
          "MEDGEN:3291",
          "MESH:D002446",
          "NCIT:C26714",
          "OMIMPS:212750",
          "Orphanet:555",
          "SCTID:396331005",
          "UMLS:C0007570",
          "icd11.foundation:2005943638"
        ],
        "synonyms": [
          "celiac disease",
          "celiac sprue",
          "coeliac sprue",
          "gluten intolerance",
          "gluten-induced enteropathy",
          "non tropical sprue"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005130"
    },
    {
      "id": 9649,
      "label": "pulmonary hemosiderosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3654,
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10328",
          "DOID:12118",
          "GARD:0006763",
          "ICD10CM:J84.03",
          "ICD9:516.1",
          "MEDGEN:9403",
          "MESH:D012806",
          "NANDO:1200751",
          "NANDO:2100037",
          "NANDO:2200207",
          "NORD:91174",
          "OMIM:178550",
          "Orphanet:99931",
          "SCTID:40527005",
          "UMLS:C0020807",
          "icd11.foundation:1542272036"
        ],
        "synonyms": [
          "Idiopathic Pulmonary Hemosiderosis",
          "idiopathic pulmonary hemosiderosis",
          "pulmonary hemosiderosis",
          "pulmonary siderosis",
          "alveolar hypoventilation syndrome",
          "siderosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A respiratory disease due to repeated episodes of diffuse alveolar hemorrhage without any underlying apparent cause, most often in children. Anemia, cough, and pulmonary infiltrates on chest radiographs are found in majority of the patients."
      },
      "child_count": 4,
      "reference_id": "MONDO:0008346"
    },
    {
      "id": 18954,
      "label": "inborn errors of metabolism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6795
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:655",
          "GARD:0022508",
          "MEDGEN:6323",
          "MESH:D008661",
          "MedDRA:10058097",
          "MedDRA:10062018",
          "NANDO:2100159",
          "NCIT:C34816",
          "Orphanet:68367",
          "SCTID:86095007",
          "UMLS:C0025521",
          "icd11.foundation:733825440"
        ],
        "synonyms": [
          "congenital metabolic disorder",
          "congenital metabolism disorder",
          "hereditary metabolic disease",
          "inborn disorders of metabolism",
          "inborn error of metabolism",
          "inborn errors of metabolism",
          "inborn metabolic disorder",
          "inherited disorder of metabolism",
          "inherited disorders of metabolism",
          "inherited metabolic disorder",
          "rare inborn errors of metabolism",
          "rare inherited metabolic disorder",
          "rare metabolic disease"
        ],
        "definition": "An inherited disorder resulting from an enzyme defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or organelle function."
      },
      "child_count": 186,
      "reference_id": "MONDO:0019052"
    },
    {
      "id": 22225,
      "label": "inherited interstitial lung disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027936",
          "OMIMPS:619611"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An instance of interstitial lung disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 26,
      "reference_id": "MONDO:0031199"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6854,
      "label": "celiac disease"
    },
    {
      "id": 9649,
      "label": "pulmonary hemosiderosis"
    },
    {
      "id": 18954,
      "label": "inborn errors of metabolism"
    },
    {
      "id": 22225,
      "label": "inherited interstitial lung disease"
    }
  ]
}