{
  "id": 24909,
  "label": "myelofibrosis with myeloid metaplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0800305",
  "properties": {
    "xrefs": [
      "GARD:0026490",
      "icd11.foundation:673220507"
    ],
    "synonyms": [
      "MMM"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 10906,
      "label": "primary myelofibrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16404,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4971",
          "EFO:0002430",
          "GARD:0008618",
          "ICD10CM:D47.4",
          "ICD9:238.76",
          "ICD9:289.83",
          "ICDO:9961/3",
          "MEDGEN:7929",
          "MESH:D055728",
          "NCIT:C2862",
          "NORD:1611",
          "OMIM:254450",
          "ONCOTREE:PMF",
          "Orphanet:824",
          "UMLS:C0001815",
          "icd11.foundation:1407285327",
          "icd11.foundation:336704235"
        ],
        "synonyms": [
          "AMM",
          "Agnogenic myeloid metaplasia",
          "CIMF",
          "chronic idiopathic myelofibrosis",
          "idiopathic bone marrow fibrosis",
          "idiopathic myelofibrosis",
          "myelofibrosis with myeloid metaplasia, somatic",
          "myelofibrosis, somatic",
          "myelosclerosis with myeloid metaplasia",
          "osteomyelofibrosis",
          "primary myelofibrosis",
          "myelofibrosis with myeloid metaplasia",
          "myelofibrosis",
          "myeloid metaplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009692"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 10906,
      "label": "primary myelofibrosis"
    }
  ]
}