{
  "id": 25070,
  "label": "metabolic bone disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0800486",
  "properties": {
    "xrefs": [
      "MEDGEN:2699",
      "NCIT:C97045",
      "UMLS:C0005944"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A group of disorders that affect the bones secondary to increased levels of minerals or deficient levels of minerals such as calcium, magnesium, phosphorus, and vitamin D. Representative examples are osteomalacia, osteoporosis, and Paget disease."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7061,
      "label": "bone disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6893
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080001",
          "EFO:0004260",
          "ICD10CM:M80-M85",
          "ICD9:731.8",
          "ICD9:733.99",
          "MEDGEN:14182",
          "MESH:D001847",
          "NANDO:2100291",
          "NANDO:2100293",
          "SCTID:76069003",
          "UMLS:C0005940"
        ],
        "synonyms": [
          "bone element disease",
          "bone element disease or disorder",
          "disease of bone element",
          "disease or disorder of bone element",
          "disorder of bone element",
          "rare bone disease related to a common gene or pathway defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Diseases of bones."
      },
      "child_count": 27,
      "reference_id": "MONDO:0005381"
    }
  ],
  "children": [
    {
      "id": 3323,
      "label": "osteomalacia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10573",
          "HP:0002749",
          "ICD9:268.2",
          "MEDGEN:14533",
          "MESH:D010018",
          "NCIT:C26838",
          "SCTID:4598005",
          "UMLS:C0029442"
        ],
        "synonyms": [
          "osteomalacia",
          "osteomalacia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003"
      },
      "child_count": 2,
      "reference_id": "MONDO:0001068"
    },
    {
      "id": 3545,
      "label": "chondrocalcinosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795,
        7223,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1156",
          "HP:0000934",
          "ICD9:275.49",
          "ICD9:712.1",
          "MEDGEN:154303",
          "MESH:D002805",
          "NCIT:C34955",
          "SCTID:239832006",
          "UMLS:C0553730",
          "icd11.foundation:2041797033"
        ],
        "synonyms": [
          "calcium pyrophosphate deposition disease",
          "pseudogout"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints."
      },
      "child_count": 9,
      "reference_id": "MONDO:0001314"
    },
    {
      "id": 6992,
      "label": "osteoporosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3153,
        24803,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11476",
          "EFO:0003882",
          "ICD10CM:M81",
          "ICD9:733.0",
          "ICD9:733.00",
          "ICD9:733.09",
          "MEDGEN:14535",
          "MESH:D010024",
          "NCIT:C3298",
          "OMIM:166710",
          "SCTID:64859006",
          "UMLS:C0029456",
          "icd11.foundation:2113001430"
        ],
        "synonyms": [
          "bone mineral density variation QTL, osteoporosis",
          "osteoporosis, postmenopausal",
          "osteoporosis, postmenopausal, susceptibility",
          "osteoporosis, susceptibility to",
          "fracture, hip, susceptibility to",
          "osteoporosis, involutional"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss)."
      },
      "child_count": 21,
      "reference_id": "MONDO:0005298"
    },
    {
      "id": 7062,
      "label": "bone Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4308,
        5714,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5408",
          "EFO:0004261",
          "ICD10CM:M88",
          "MEDGEN:10493",
          "NCIT:C3292",
          "OMIMPS:167250",
          "Orphanet:280110",
          "SCTID:2089002",
          "UMLS:C0029401"
        ],
        "synonyms": [
          "Paget disease of bone",
          "Paget's bone disease",
          "Paget's disease of bone",
          "Paget's disease of the bone",
          "Pagets disease (bone)",
          "bone Paget disease",
          "bone Paget's disease",
          "osseous Paget's disease",
          "osteitis deformans",
          "Paget's disease",
          "familial Paget's disease of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue."
      },
      "child_count": 15,
      "reference_id": "MONDO:0005382"
    }
  ],
  "roots": [
    {
      "id": 7061,
      "label": "bone disorder"
    }
  ]
}