{
  "id": 25086,
  "label": "childhood-onset self-limited focal epilepsy syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0800502",
  "properties": {
    "xrefs": [
      "GARD:0027305"
    ],
    "synonyms": [
      "childhood-onset SeLFE"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of conditions characterized by age-dependent occurrence in otherwise normal children. Cognition and neurological evaluation are typically normal. Remission occurs in almost all patients by puberty. Presumed genetic factors have an important role. Seizure semiology and electroencephalographic (EEG) features are specific for each of the syndromes included in this group."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7064,
      "label": "focal epilepsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6761
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2234",
          "EFO:0004263",
          "ICD9:345.50",
          "MEDGEN:41836",
          "MESH:D004828",
          "NCIT:C122812",
          "SCTID:230381009",
          "UMLS:C0014547"
        ],
        "synonyms": [
          "focal epilepsy",
          "partial epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A seizure caused by a localized disorder."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005384"
    },
    {
      "id": 19725,
      "label": "childhood-onset epilepsy syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16436
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019437",
          "MEDGEN:1843031",
          "Orphanet:98259",
          "UMLS:C5681526"
        ],
        "synonyms": [
          "childhood epilepsy syndrome",
          "childhood-onset epilepsy syndrome",
          "epilepsy syndrome of childhood",
          "paediatric epilepsy syndrome",
          "pediatric epilepsy syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A epilepsy syndrome that occurs during childhood."
      },
      "child_count": 16,
      "reference_id": "MONDO:0020072"
    }
  ],
  "children": [
    {
      "id": 8695,
      "label": "self-limited epilepsy with centrotemporal spikes",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17942,
        25086
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3329",
          "GARD:0010287",
          "ICD9:345.80",
          "MEDGEN:138210",
          "NCIT:C116538",
          "OMIM:117100",
          "Orphanet:1945",
          "SCTID:44145005",
          "UMLS:C0376532",
          "icd11.foundation:1046279423"
        ],
        "synonyms": [
          "BCECTS",
          "BECRS",
          "BECTS",
          "BRE",
          "Rolandic epilepsy",
          "benign Rolandic epilepsy",
          "benign Rolandic epilepsy (BRE)",
          "benign Rolandic epilepsy of childhood (BREC)",
          "benign childhood epilepsy with centrotemporal spikes",
          "benign epilepsy of childhood with centrotemporal spikes",
          "benign epilepsy with centrotemporal spikes",
          "benign familial epilepsy of childhood with rolandic spikes",
          "centralopathic epilepsy",
          "centrotemporal epilepsy",
          "centrotemporal epilepsy, isolated cases",
          "childhood epilepsy with centrotemporal spikes",
          "temporal-central focal epilepsy",
          "benign epilepsy of childhood with centrotemporal spikes (BECCT)",
          "benign epilepsy with centro-temporal spikes (BECTS)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A childhood-onset epilepsy syndrome that is characterized by onset of seizures between 3 and 14 years (peak 8-9 years) that usually resolve by age 13 years, but can occasionally occur up to age 18 years of age. Both sexes are affected. Antecedent, birth and neonatal history is normal. A history of febrile seizure (in 5-15%) may be seen. A history of Panayiotopoulos syndrome may be present in a very small number of cases. Neurological exam and head size is normal. Development and cognition prior to onset of seizures is normal. During the course of the active epilepsy, behavioral and neuropsychological deficits may be found, particularly in language and executive functioning. These deficits improve when seizures remit."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007295"
    },
    {
      "id": 19787,
      "label": "self-limited epilepsy with autonomic seizures",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8938,
        25086
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019581",
          "ICD9:345.80",
          "MEDGEN:581520",
          "Orphanet:98815",
          "SCTID:230387008",
          "UMLS:C0393676"
        ],
        "synonyms": [
          "Panayiotopoulos syndrome",
          "SeLEAS",
          "benign childhood occipital epilepsy, Panayiotopoulos type",
          "early onset benign occipital epilepsy",
          "early-onset benign childhood occipital epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A childhood-onset self-limited focal epilepsy syndrome characterized by the onset in early childhood of focal autonomic seizures that are often prolonged. The EEG commonly shows high amplitude focal spikes typically activated by sleep. Seizures are infrequent in most patients. Seizures are self-limiting with remission typically within a few years from onset."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020307"
    },
    {
      "id": 19788,
      "label": "childhood occipital visual epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8938,
        25086
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019582",
          "MEDGEN:581521",
          "Orphanet:98816",
          "UMLS:C0393677"
        ],
        "synonyms": [
          "COVE",
          "benign childhood occipital epilepsy, Gastaut type",
          "childhood occipital epilepsy (Gastaut type)",
          "late-onset benign childhood occipital epilepsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, genetic neurological disorder characterized by childhood to mid-adolescence onset of frequent, brief, diurnal simple partial seizures which usually begin with visual hallucinations (e.g. phosphenes) and/or ictal blindness and may associate non visual seizures (such as deviation of the eyes, oculoclonic seizures), forced eyelid closure and blinking and sensory hallucinations. Post-ictal headache is common while impairment of consciousness is rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020308"
    },
    {
      "id": 23779,
      "label": "photosensitive occipital lobe epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25086
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1871245",
          "UMLS:C5967452"
        ],
        "synonyms": [
          "POLE"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A childhood-onset epilepsy that is characterized by the presence of visually-induced focal occipital lobe seizures. A proportion of patients with this syndrome have developmental delays and learning difficulty."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100021"
    }
  ],
  "roots": [
    {
      "id": 7064,
      "label": "focal epilepsy"
    },
    {
      "id": 19725,
      "label": "childhood-onset epilepsy syndrome"
    }
  ]
}