{
  "id": 25135,
  "label": "autoimmune limbic encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850097",
  "properties": {
    "xrefs": [
      "GARD:0022492",
      "MEDGEN:419645",
      "Orphanet:623615",
      "UMLS:C2930824",
      "icd11.foundation:1254443511"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare autoimmune encephalitis involving the mesial temporal lobes and clinically characterized by subacute onset (i. e. rapid progression of less than three months) of short-term memory deficits, seizures or psychiatric symptoms, such as behavioral changes, anxiety, depression, and psychosis. Further diagnostic criteria are bilateral abnormalities restricted to the mesial temporal lobes in brain MRI, cerebrospinal fluid pleocytosis and/or epileptic or slow-wave activity involving the temporal lobes in EEG, and reasonable exclusion of alternative causes. Paraneoplastic or non-paraneoplastic antibodies against neuronal antigens may be found in serum and/or cerebrospinal fluid."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16388,
      "label": "limbic encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080741",
          "GARD:0008742",
          "ICD9:323.9",
          "MEDGEN:137895",
          "MESH:D020363",
          "Orphanet:163892",
          "SCTID:230192003",
          "UMLS:C0338430"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain.The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however,symptoms may also include confusion, psychiatric symptoms, and seizures.The symptomstypically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic limbic encephalitis). Delayed diagnosis is common, but improvements are being made to assist in early detection. Various tests including imaging studies (MRI, PET) laboratory tests (CSF analysis), and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis. Treatment includes removal of the neoplasm (if identified) and immunotherapy."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015588"
    },
    {
      "id": 20055,
      "label": "autoimmune encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011979",
          "MEDGEN:1804547",
          "NANDO:2100248",
          "NANDO:2200902",
          "NCIT:C122414",
          "Orphanet:622014",
          "SCTID:95643007",
          "UMLS:C5671289",
          "icd11.foundation:241281019"
        ],
        "synonyms": [
          "autoimmune encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the brain secondary to an immune response triggered by the body itself."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020640"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16388,
      "label": "limbic encephalitis"
    },
    {
      "id": 20055,
      "label": "autoimmune encephalitis"
    }
  ]
}