{
  "id": 25166,
  "label": "B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850157",
  "properties": {
    "xrefs": [
      "DOID:0080645",
      "GARD:0026584"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A B-lymphoblastic leukemia/lymphoma that is characterized by the presence of lymphoblasts that carry a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6692,
      "label": "B-cell acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080630",
          "DOID:7061",
          "EFO:0000094",
          "GARD:0024135",
          "MEDGEN:226949",
          "NCIT:C8936",
          "SCTID:277571004",
          "UMLS:C1292769"
        ],
        "synonyms": [
          "B lymphoblastic leukemia/lymphoma",
          "precursor B lymphoblastic leukemia/lymphoma",
          "precursor B-lymphoblastic lymphoma/leukemia",
          "precursor B lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001)"
      },
      "child_count": 32,
      "reference_id": "MONDO:0004947"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6692,
      "label": "B-cell acute lymphoblastic leukemia"
    }
  ]
}