{
  "id": 25173,
  "label": "medulloblastoma non-WNT/non-SHH",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850198",
  "properties": {
    "xrefs": [
      "DOID:0080706",
      "GARD:0026591",
      "MEDGEN:1387799",
      "NCIT:C129444",
      "UMLS:C4330667"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A medulloblastoma that is characterized as a molecular subtype that is not associated with activation of the WNT pathway or sonic hedgehog (SHH) pathway and TP53 mutations are absent."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 9288,
      "label": "medulloblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4920,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050902",
          "DOID:0060104",
          "EFO:0002939",
          "GARD:0007005",
          "ICDO:9470/3",
          "MEDGEN:7517",
          "MESH:D008527",
          "MedDRA:10027107",
          "NANDO:2200090",
          "NCIT:C3222",
          "NORD:1422",
          "OMIM:155255",
          "ONCOTREE:MBL",
          "Orphanet:616",
          "SCTID:443333004",
          "UMLS:C0025149",
          "icd11.foundation:290815825"
        ],
        "synonyms": [
          "cerebellum embryonal neoplasm",
          "medulloblastoma",
          "medulloblastoma, autosomal recessive, autosomal dominant, somatic mutation",
          "medulloblastoma, desmoplastic, autosomal recessive, autosomal dominant, somatic mutation",
          "medulloblastoma, malignant",
          "medulloblastoma, somatic",
          "medulloblastomas",
          "CNS PNET",
          "CPNET",
          "MDB",
          "infratentorial primitive neuroectodermal tumor",
          "infratentorial primitive neuroectodermal tumour",
          "localised primitive neuroectodermal tumour",
          "localized primitive neuroectodermal tumor",
          "medulloblastoma with extensive nodularity",
          "medulloblastoma, desmoplastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity."
      },
      "child_count": 28,
      "reference_id": "MONDO:0007959"
    }
  ],
  "children": [
    {
      "id": 25566,
      "label": "medulloblastoma non-WNT/non-SHH group 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25173
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080707",
          "GARD:0026770",
          "MEDGEN:1389944",
          "NCIT:C129445",
          "UMLS:C4330665"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A medulloblastoma non-WNT/non-SHH that is characterized as a molecular subtype by absent TP53 mutations and MYC amplifications that may be present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956966"
    },
    {
      "id": 25567,
      "label": "medulloblastoma non-WNT/non-SHH group 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25173
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080708",
          "GARD:0026771",
          "MEDGEN:1377534",
          "NCIT:C129446",
          "UMLS:C4330666"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A medulloblastoma non-WNT/non-SHH that is characterized as a molecular subtype by the absence of MYC amplifications and TP53 mutations, while chromosome 17 abnormalities may be present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956967"
    }
  ],
  "roots": [
    {
      "id": 9288,
      "label": "medulloblastoma"
    }
  ]
}