{
  "id": 25184,
  "label": "myeloid leukemia associated with down syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850271",
  "properties": {
    "xrefs": [
      "DOID:0080798",
      "GARD:0026597",
      "MEDGEN:416725",
      "NCIT:C43223",
      "UMLS:C2825149"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An acute megakaryocytic leukemia occurring in children with Down syndrome and that has material basis in mutation in the GATA1 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18804,
      "label": "acute megakaryoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16444
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8761",
          "EFO:0003025",
          "GARD:0000524",
          "ICD10CM:C94.2",
          "ICD9:207.2",
          "ICDO:9910/3",
          "MEDGEN:44124",
          "MESH:D007947",
          "MedDRA:10060556",
          "NANDO:2200011",
          "NCIT:C3170",
          "ONCOTREE:AMKL",
          "Orphanet:518",
          "SCTID:277602003",
          "UMLS:C0023462",
          "Wikipedia:Acute_megakaryoblastic_leukemia",
          "icd11.foundation:2057381869"
        ],
        "synonyms": [
          "AMKL",
          "AML M7",
          "FAB M7",
          "acute M7 myeloid leukaemia",
          "acute M7 myeloid leukemia",
          "acute megakaryoblastic leukaemia (FAB type M7)",
          "acute megakaryoblastic leukemia",
          "acute megakaryoblastic leukemia (FAB type M7)",
          "acute megakaryoblastic leukemia, FAB M7",
          "acute megakaryocytic leukaemia",
          "acute megakaryocytic leukemia",
          "acute megakaryocytic leukemias",
          "acute myeloid leukaemia M7",
          "acute myeloid leukemia M7",
          "leukemia, megakaryocytic, malignant",
          "thrombocytic leukemia",
          "acute myeloblastic leukaemia type 7",
          "acute myeloblastic leukemia type 7",
          "megakaryocytic leukaemia",
          "megakaryocytic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis."
      },
      "child_count": 5,
      "reference_id": "MONDO:0018872"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18804,
      "label": "acute megakaryoblastic leukemia"
    }
  ]
}