{
  "id": 25187,
  "label": "chronic asthma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850282",
  "properties": {
    "xrefs": [
      "DOID:0080809",
      "MEDGEN:1843404",
      "UMLS:C0877430"
    ],
    "synonyms": [
      "adult-onset severe asthma",
      "persistent mild asthma",
      "persistent moderate asthma",
      "persistent severe asthma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "An asthma that is characterized by the development of persistent airway inflammation and recurrent attacks of breathlessness and wheezing, which vary in severity and frequency."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6720,
      "label": "asthma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3582
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2841",
          "HP:0002099",
          "ICD10CM:J45",
          "ICD10WHO:J45",
          "ICD9:493",
          "ICD9:493.81",
          "ICD9:493.9",
          "MEDGEN:2109",
          "MESH:D001249",
          "NCIT:C28397",
          "SCTID:31387002",
          "UMLS:C0004096",
          "icd11.foundation:1656445230"
        ],
        "synonyms": [
          "chronic obstructive asthma",
          "chronic obstructive asthma with acute exacerbation",
          "chronic obstructive asthma with status asthmaticus",
          "exercise induced asthma",
          "exercise-induced asthma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004979"
    }
  ],
  "children": [
    {
      "id": 25189,
      "label": "extrinsic asthma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080811"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic asthma that is triggered by an allergen and that is characterized by an immune system overreaction to a harmless substance, such as pollen or dust, with the subsequent release of immunoglobin E (IgE) antibodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850284"
    },
    {
      "id": 25569,
      "label": "intermittent asthma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080812",
          "MEDGEN:740576",
          "UMLS:C1740754"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic asthma that is characterized by severity with symptoms two or fewer days per week, nighttime awakenings two or fewer times per month, use of short-acting beta agonist for symptom control two or fewer days per week and no interference with normal activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956971"
    },
    {
      "id": 25570,
      "label": "T2-high asthma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080817"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic asthma that is characterized by the pathophysiology phenotype combination (endotype) of early-onset allergic asthma, late-onset eosinophilic asthma, and aspirin-exacerbated respiratory disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956975"
    },
    {
      "id": 25571,
      "label": "T2-low asthma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080818"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic asthma that is characterized by the pathophysiology phenotype combination (endotype) of non-atopic, smoking, obesity related, and elderly and that is characterized by neutrophilic (sputum neutrophils > 40–60%) or paucigranulocytic (i.e., normal sputum levels of both eosinophils and neutrophils) inflammation and a lack of response to corticosteroid therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956976"
    },
    {
      "id": 25573,
      "label": "nocturnal asthma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080826",
          "MEDGEN:696950",
          "UMLS:C1273489"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic asthma that is characterized by significant decline in pulmonary function and increase of airway inflammation at night. During sleep, recumbent posture causes a reduction in the lung volumes, respiratory muscle tone, and lung compliance. The overnight physiological abnormalities include: increased airway inflammation and decreased steroid responsiveness, increased pulmonary capillary blood volume, functional differences in blood/air volume ratios and mechanical coupling of the parenchyma to the airways."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956979"
    }
  ],
  "roots": [
    {
      "id": 6720,
      "label": "asthma"
    }
  ]
}