{
  "id": 25201,
  "label": "IDH-mutant anaplastic astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850332",
  "properties": {
    "xrefs": [
      "DOID:0080875",
      "GARD:0026601"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An anaplastic astrocytoma carrying IDH mutations."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 17148,
      "label": "anaplastic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144,
        19525,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3078",
          "EFO:0002499",
          "GARD:0005860",
          "ICDO:9401/3",
          "MEDGEN:137784",
          "MedDRA:10002224",
          "MedDRA:10060971",
          "NANDO:2200086",
          "NCIT:C9477",
          "NORD:769",
          "ONCOTREE:AASTR",
          "Orphanet:251589",
          "UMLS:C0334579"
        ],
        "synonyms": [
          "anaplastic astrocytoma",
          "astrocytoma, anaplastic, malignant",
          "grade III astrocytic neoplasm",
          "grade III astrocytic tumor",
          "grade III astrocytic tumour",
          "grade III astrocytoma",
          "malignant astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016684"
    }
  ],
  "children": [
    {
      "id": 25575,
      "label": "astrocytoma, IDH-mutant, grade 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25201
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080877",
          "GARD:0026772",
          "MEDGEN:1718223",
          "NCIT:C167335",
          "UMLS:C5238471"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An IDH-mutant anaplastic astrocytoma that is characterized by the presence of necrosis and/or microvascular proliferation or homozygous deletion of CDKN2A and/or CDKN2B genes. The term glioblastoma no longer applies to central nervous system WHO grade 4 IDH-mutant astrocytomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956981"
    },
    {
      "id": 25587,
      "label": "astrocytoma, IDH-mutant, grade 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25201
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081256",
          "GARD:0026781",
          "MEDGEN:927224",
          "NCIT:C129271",
          "UMLS:C4289692"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An IDH-mutant anaplastic astrocytoma that is characterized by the presence of well-differentiated fibrillary glial cells diffusely infiltrating the central nervous system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956994"
    },
    {
      "id": 25588,
      "label": "astrocytoma, IDH-mutant, grade 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25201
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081257",
          "GARD:0026782",
          "MEDGEN:927513",
          "NCIT:C129290",
          "UMLS:C4289981"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An IDH-mutant anaplastic astrocytoma that is characterized by the presence of increased mitotic activity and anaplastic features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956995"
    }
  ],
  "roots": [
    {
      "id": 17148,
      "label": "anaplastic astrocytoma"
    }
  ]
}