{
  "id": 25205,
  "label": "posterior fossa ependymoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850339",
  "properties": {
    "xrefs": [
      "DOID:0080889",
      "GARD:0026605",
      "MEDGEN:1811888",
      "NCIT:C186443",
      "UMLS:C5670542"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A high grade ependymoma that is located within the posterior fossa."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 17163,
      "label": "anaplastic ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5074",
          "DOID:5889",
          "GARD:0010634",
          "ICDO:9392/3",
          "MEDGEN:128891",
          "MedDRA:10014968",
          "NCIT:C4049",
          "ONCOTREE:APE",
          "Orphanet:251646",
          "UMLS:C0280788"
        ],
        "synonyms": [
          "ependymal tumors",
          "ependymal tumours",
          "WHO grade III ependymal neoplasm",
          "WHO grade III ependymal tumor",
          "WHO grade III ependymal tumour",
          "anaplastic ependymal neoplasm",
          "anaplastic ependymal tumor",
          "anaplastic ependymal tumour",
          "anaplastic ependymoma",
          "ependymoma, anaplastic, malignant",
          "ependymoma, malignant",
          "high-grade ependymoma",
          "malignant ependymoma",
          "undifferentiated ependymal neoplasm",
          "undifferentiated ependymal tumor",
          "undifferentiated ependymal tumour",
          "undifferentiated ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016700"
    }
  ],
  "children": [
    {
      "id": 25585,
      "label": "posterior fossa group A ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25205
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081254",
          "GARD:0026779",
          "MEDGEN:1810123",
          "NCIT:C186450",
          "UMLS:C5670548"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A posterior fossa ependymoma that arises in the posterior fossa with characteristic DNA methylation patterns, including CpG island hypermethylation, global DNA hypomethylation, reduction of nuclear H3 p.K28me3 (K27me3) expression, and EZHIP overexpression."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956992"
    },
    {
      "id": 25586,
      "label": "posterior fossa group B ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25205
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081255",
          "GARD:0026780",
          "NCIT:C186451"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A posterior fossa ependymoma that arises in the posterior fossa with characteristic DNA methylation patterns including retention of nuclear H3 p.K28me3 (K27me3) expression, absence of CpG island hypermethylation, absence of global DNA hypomethylation, and absence of EZHIP overexpression."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956993"
    }
  ],
  "roots": [
    {
      "id": 17163,
      "label": "anaplastic ependymoma"
    }
  ]
}