{
  "id": 25206,
  "label": "supratentorial ependymoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0850340",
  "properties": {
    "xrefs": [
      "DOID:0080890",
      "GARD:0026606",
      "MEDGEN:1811811",
      "NCIT:C186343",
      "UMLS:C5670470"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A high grade ependymoma that is located within the supratentorial brain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 17163,
      "label": "anaplastic ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5210,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5074",
          "DOID:5889",
          "GARD:0010634",
          "ICDO:9392/3",
          "MEDGEN:128891",
          "MedDRA:10014968",
          "NCIT:C4049",
          "ONCOTREE:APE",
          "Orphanet:251646",
          "UMLS:C0280788"
        ],
        "synonyms": [
          "ependymal tumors",
          "ependymal tumours",
          "WHO grade III ependymal neoplasm",
          "WHO grade III ependymal tumor",
          "WHO grade III ependymal tumour",
          "anaplastic ependymal neoplasm",
          "anaplastic ependymal tumor",
          "anaplastic ependymal tumour",
          "anaplastic ependymoma",
          "ependymoma, anaplastic, malignant",
          "ependymoma, malignant",
          "high-grade ependymoma",
          "malignant ependymoma",
          "undifferentiated ependymal neoplasm",
          "undifferentiated ependymal tumor",
          "undifferentiated ependymal tumour",
          "undifferentiated ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016700"
    }
  ],
  "children": [
    {
      "id": 25577,
      "label": "YAP1-MAMLD1 fusion-positive supratentorial ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080891",
          "GARD:0026774",
          "MEDGEN:1810688",
          "NCIT:C186355",
          "UMLS:C5670480"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A supratentorial ependymoma that has material basis in YAP1-MAMLD1 fusion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956984"
    },
    {
      "id": 25583,
      "label": "supratentorial ependymoma, ZFTA fusion–positive",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081252",
          "GARD:0026777",
          "NCIT:C186350"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A suptratentorial ependymoma that is characterized by the presence of a fusion gene involving ZFTA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956990"
    },
    {
      "id": 25584,
      "label": "supratentorial ependymoma, YAP1 fusion–positive",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25206
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081253",
          "GARD:0026778",
          "NCIT:C186351"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A supratentorial ependymoma that is characterized by the presence of a fusion gene involving YAP1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956991"
    }
  ],
  "roots": [
    {
      "id": 17163,
      "label": "anaplastic ependymoma"
    }
  ]
}