{
  "id": 25549,
  "label": "IDH-mutant and 1p/19q-codeleted oligodendroglioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0859592",
  "properties": {
    "xrefs": [
      "DOID:0080882",
      "GARD:0026754",
      "MEDGEN:926090",
      "NCIT:C129318",
      "UMLS:C4288558"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An anaplastic oligodendroglioma that has material basis in IDH gene family mutation and combined whole-arm losses of 1p and 19q (1p/19q codeletion)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 17159,
      "label": "anaplastic oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18713,
        20048,
        20696
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7154",
          "EFO:0002501",
          "GARD:0009472",
          "ICDO:9451/3",
          "MEDGEN:90812",
          "MedDRA:10026659",
          "NCIT:C4326",
          "ONCOTREE:AODG",
          "Orphanet:251630",
          "UMLS:C0334590"
        ],
        "synonyms": [
          "WHO grade III oligodendroglial neoplasm",
          "WHO grade III oligodendroglial tumor",
          "WHO grade III oligodendroglial tumour",
          "anaplastic oligodendroglioma",
          "malignant oligodendroglioma",
          "oligodendroglioma, anaplastic, malignant",
          "oligodendroglioma, malignant",
          "undifferentiated oligodendroglioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0016696"
    }
  ],
  "children": [
    {
      "id": 25589,
      "label": "oligodendroglioma, IDH-mutant and 1p/19q-codeleted grade 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25549
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081281",
          "GARD:0026783"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An IDH-mutant, and 1p/19q-codeleted oligodendroglioma that is characterized as a well differentiated tumor lacking anaplastic features (brisk mitotic activity, microvascular proliferation, necrosis)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956996"
    },
    {
      "id": 25590,
      "label": "oligodendroglioma, IDH-mutant and 1p/19q-codeleted, grade 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        25549
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081282",
          "GARD:0026784"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An IDH-mutant, and 1p/19q-codeleted oligodendroglioma that is characterized as grade 3 tumors associated with a more rapid growth. Grade 3 tumors appear to have abnormalities on chromosomes 9 or 10, along with unusual amounts of growth factors and proteins, which are thought to contribute to the more rapid growth of these gliomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0956997"
    }
  ],
  "roots": [
    {
      "id": 17159,
      "label": "anaplastic oligodendroglioma"
    }
  ]
}