{
  "id": 25553,
  "label": "diffuse astrocytoma, MYB- or MYBL1-altered",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0859615",
  "properties": {
    "xrefs": [
      "DOID:0081279",
      "GARD:0026758"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A diffuse astrocytoma that is a diffusely infiltrative astroglial neoplasm composed of monomorphic cells with genetic alterations in MYB or MYBL1."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4857",
          "GARD:0005907",
          "MEDGEN:83708",
          "NANDO:2200085",
          "NCIT:C7173",
          "ONCOTREE:DASTR",
          "Orphanet:251595",
          "UMLS:C0280785"
        ],
        "synonyms": [
          "WHO grade II astrocytoma",
          "astrocytoma, diffuse",
          "astrocytoma, diffuse, malignant",
          "diffuse astrocytoma",
          "grade II astrocytic neoplasm",
          "grade II astrocytic tumor",
          "grade II astrocytic tumour",
          "grade II astrocytoma",
          "fibrillary astrocytoma (histologic variant)",
          "gemistocytic astrocytoma (histologic variant)",
          "low-grade diffuse astrocytoma",
          "protoplasmic astrocytoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016686"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma"
    }
  ]
}