{
  "id": 25672,
  "label": "endogenous Cushing syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0957431",
  "properties": {
    "xrefs": [
      "GARD:0026827",
      "MEDGEN:1727013",
      "Orphanet:641613",
      "UMLS:C5419158"
    ],
    "synonyms": [
      "endogenous CS"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Any Cushing syndrome caused by body's prolonged overproduction of cortisol that can be dependent on or independent of adrenocorticotropic hormone (ACTH)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7151,
      "label": "adrenal gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9553",
          "EFO:0005539",
          "ICD9:255",
          "ICD9:255.8",
          "ICD9:255.9",
          "MEDGEN:892577",
          "MESH:D000307",
          "NCIT:C26690",
          "SCTID:30171000",
          "UMLS:C4021794"
        ],
        "synonyms": [
          "adrenal gland disease",
          "adrenal gland disease or disorder",
          "adrenal gland diseases",
          "adrenal gland disorder",
          "adrenal gland disorders",
          "disease of adrenal gland",
          "disease or disorder of adrenal gland",
          "disorder of adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the adrenal gland."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005495"
    },
    {
      "id": 18839,
      "label": "Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003099",
          "GARD:0006224",
          "ICD10CM:E24",
          "ICD10WHO:E24",
          "ICD9:255.0",
          "MEDGEN:3681",
          "MESH:D003480",
          "MedDRA:10011652",
          "MedDRA:10020562",
          "MedDRA:10020564",
          "MedDRA:10020610",
          "NCIT:C2969",
          "Orphanet:553",
          "UMLS:C0010481",
          "icd11.foundation:1654321425"
        ],
        "synonyms": [
          "hypercortisolism",
          "Cushing syndrome",
          "Cushing's syndrome",
          "cortisol Excess",
          "hyperadrenocorticism",
          "pituitary basophilism",
          "suprarenogenic syndrome",
          "adrenal hyperfunction resulting from pituitary ACTH excess",
          "ectopic adrenocorticotropic hormone syndrome",
          "nodular primary adrenocortical dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Cushing's syndrome (CS) encompasses a group of hormonal disorders caused by prolonged and high exposure levels to glucocorticoids that can be of either endogenous (adrenal cortex production) or exogenous (iatrogenic) origin."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018912"
    }
  ],
  "children": [
    {
      "id": 19975,
      "label": "ACTH-dependent Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8241,
        25672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3946",
          "EFO:1001110",
          "GARD:0019699",
          "ICD10CM:E24.0",
          "MEDGEN:575036",
          "MESH:D047748",
          "MedDRA:10035109",
          "Orphanet:99892",
          "SCTID:190502001",
          "SCTID:237734007",
          "UMLS:C0342442",
          "icd11.foundation:212778081"
        ],
        "synonyms": [
          "ACTH-dependent CS",
          "adrenocorticotropic hormone-dependent Cushing syndrome",
          "corticotropin-dependent Cushing syndrome",
          "pituitary-dependent Cushing's disease",
          "ACTH hypersecretion, pituitary",
          "adrenocorticotropic hormone, inappropriate secretion",
          "pituitary Cushing disease",
          "pituitary Cushing diseases",
          "pituitary Cushing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A group of endogenous Cushing syndrome caused by abnormal production of ACTH due to pituitary adenoma or an extrapituitary tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020528"
    },
    {
      "id": 19976,
      "label": "ACTH-independent Cushing syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        25672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019700",
          "MEDGEN:575037",
          "Orphanet:647758",
          "Orphanet:99893",
          "UMLS:C0342443",
          "icd11.foundation:652536990"
        ],
        "synonyms": [
          "adrenal Cushing syndrome",
          "adrenocorticotropic hormone-independent Cushing syndrome",
          "corticotropin-independent Cushing syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A group of endogenous Cushing syndrome  that may result from excess secretion of cortisol by either a unilateral and benign, or malignant adrenocortical tumor, or nodular adrenocortical disease."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020529"
    }
  ],
  "roots": [
    {
      "id": 7151,
      "label": "adrenal gland disorder"
    },
    {
      "id": 18839,
      "label": "Cushing syndrome"
    }
  ]
}