{
  "id": 26194,
  "label": "leukodystrophy, demyelinating, adult-onset",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0976138",
  "properties": {
    "xrefs": [
      "GARD:0027431"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 18952,
      "label": "leukodystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050987",
          "DOID:0060786",
          "DOID:10579",
          "GARD:0006895",
          "ICD9:330.0",
          "MEDGEN:6070",
          "MedDRA:10024381",
          "NANDO:1200575",
          "NANDO:2200836",
          "NCIT:C61253",
          "NORD:1367",
          "OMIMPS:312080",
          "Orphanet:68356",
          "SCTID:192781003",
          "UMLS:C0023520",
          "icd11.foundation:468040251"
        ],
        "synonyms": [
          "hypomyelinating leukodystrophy",
          "hypomyelinating leukoencephalopathy",
          "leukodystrophy, hypomyelinating"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Leukodystrophies are a group of rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each type of leukodystrophy is caused by a specific gene abnormality that leads to abnormal development or destruction of the white matter (myelin sheath) of the brain. The myelin sheath is the protective covering of the nerve and nerves can't function normally without it. Each type of leukodystrophy affects a different part of the myelin sheath, leading to a range of neurological problems."
      },
      "child_count": 65,
      "reference_id": "MONDO:0019046"
    }
  ],
  "children": [
    {
      "id": 9523,
      "label": "adult-onset autosomal dominant demyelinating leukodystrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17371,
        20345,
        26194
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DECIPHER:59",
          "DOID:0051015",
          "DOID:0060785",
          "GARD:0010587",
          "MEDGEN:356995",
          "MESH:C566813",
          "OMIMPS:169500",
          "Orphanet:99027",
          "SCTID:448054001",
          "UMLS:C1868512"
        ],
        "synonyms": [
          "ADLD",
          "adult-onset autosomal dominant demyelinating leukodystrophy",
          "adult-onset autosomal dominant leukodystrophy",
          "leukodystrophy, adult-onset, autosomal dominant",
          "Pelizaeus-Merzbacher disease, autosomal dominant or late-onset type",
          "Pelizaeus-Merzbacher disease, autosomal dominant or late-onset type, formerly",
          "autosomal dominant adult-onset demyelinating leukodystrophy",
          "autosomal dominant leukodystrophy with autonomic disease",
          "leukodystrophy, demyelinating, ADULT-onset, autosomal dominant",
          "multiple sclerosis-like disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare, slowly progressive neurological disorder involving central nervous system demyelination, leading to autonomic dysfunction, ataxia and mild cognitive impairment."
      },
      "child_count": 6,
      "reference_id": "MONDO:0008215"
    }
  ],
  "roots": [
    {
      "id": 18952,
      "label": "leukodystrophy"
    }
  ]
}