{
  "id": 29334,
  "label": "diffuse midline glioma, H3 K27-altered",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:1060171",
  "properties": {
    "xrefs": [
      "GARD:0028173",
      "MEDGEN:1811313",
      "NCIT:C185368",
      "UMLS:C5669877"
    ],
    "synonyms": [
      "DMG, H3 K27-altered"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7619,
      "label": "diffuse intrinsic pontine glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000026",
          "GARD:0013075",
          "MEDGEN:458884",
          "MESH:D000080443",
          "NCIT:C94764",
          "ONCOTREE:DIPG",
          "Orphanet:497188",
          "UMLS:C2986658"
        ],
        "synonyms": [
          "DIPG",
          "diffuse midline glioma",
          "infiltrative brainstem glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006033"
    }
  ],
  "children": [
    {
      "id": 25600,
      "label": "diffuse midline glioma, H3 K27M-mutant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        29334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080684",
          "GARD:0026785",
          "MEDGEN:927220",
          "NCIT:C129309",
          "UMLS:C4289688"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A histone mutated tumor that is characterized by the presence of histone H3 K27M mutation located throughout the midline structures of the central nervous system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0957196"
    }
  ],
  "roots": [
    {
      "id": 7619,
      "label": "diffuse intrinsic pontine glioma"
    }
  ]
}