{
  "id": 29358,
  "label": "primary hyperthyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:1060200",
  "properties": {
    "xrefs": [
      "MEDGEN:811409",
      "UMLS:C3714618"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology within the thyroid gland itself. Primary hyperthyroidism is characterized by low TSH levels and elevated T3/T4 levels."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6233,
      "label": "hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7998",
          "EFO:0009189",
          "ICD9:242.90",
          "MEDGEN:6972",
          "MESH:D006980",
          "NANDO:2100119",
          "NANDO:2200329",
          "NCIT:C3123",
          "SCTID:34486009",
          "UMLS:C0020550"
        ],
        "synonyms": [
          "overactive thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004425"
    }
  ],
  "children": [
    {
      "id": 3491,
      "label": "toxic multinodular goitre",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11277",
          "EFO:0009191",
          "ICD9:242.3",
          "ICD9:242.30",
          "MEDGEN:137963",
          "NCIT:C35171",
          "SCTID:57777000",
          "UMLS:C0342127",
          "icd11.foundation:999910988"
        ],
        "synonyms": [
          "MNG",
          "Plummer disease",
          "Plummer's disease",
          "TMNG",
          "Toxic goiter",
          "Toxic goitre",
          "toxic nodular goiter",
          "toxic nodular goitre"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Nodular enlargement of the thyroid gland associated with hyperthyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001252"
    },
    {
      "id": 7047,
      "label": "Graves disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3354,
        7262,
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12361",
          "EFO:0004237",
          "ICD9:242.0",
          "MEDGEN:6677",
          "MESH:D006111",
          "NANDO:2200328",
          "NCIT:C3071",
          "SCTID:353295004",
          "UMLS:C0018213"
        ],
        "synonyms": [
          "Graves disease",
          "Basedow disease",
          "Graves' hyperthyroidism",
          "parry disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005364"
    },
    {
      "id": 29360,
      "label": "toxic thyroid adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6766,
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:549890",
          "UMLS:C0302840"
        ],
        "synonyms": [
          "toxic adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A condition in which a single benign adenoma on the thyroid gland  autonomously secretes excessive thyroid hormone, leading to primary hyperthyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060202"
    }
  ],
  "roots": [
    {
      "id": 6233,
      "label": "hyperthyroidism"
    }
  ]
}