{
  "id": 29359,
  "label": "secondary hyperthyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:1060201",
  "properties": {
    "xrefs": [
      "MEDGEN:923144",
      "UMLS:C1095928"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology outside of the thyroid gland, namely in the hypothalamus or pituitary gland. Secondary hyperthyroidism is characterized by elevated TSH levels and elevated T3/T4 levels."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6233,
      "label": "hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7998",
          "EFO:0009189",
          "ICD9:242.90",
          "MEDGEN:6972",
          "MESH:D006980",
          "NANDO:2100119",
          "NANDO:2200329",
          "NCIT:C3123",
          "SCTID:34486009",
          "UMLS:C0020550"
        ],
        "synonyms": [
          "overactive thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004425"
    }
  ],
  "children": [
    {
      "id": 5705,
      "label": "TSH producing pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5357,
        16048,
        29359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6275",
          "GARD:0023689",
          "MEDGEN:391700",
          "NCIT:C7915",
          "SCTID:254959007",
          "UMLS:C2362538"
        ],
        "synonyms": [
          "TSH-producing pituitary gland tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces thyrotropin."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003837"
    },
    {
      "id": 29361,
      "label": "hypothalamic hyperthyroidism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        29359
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of secondary hyperthyroidism caused by pathology in the hypothalamus leading to excessive stimulation of the pituitary gland and subsequent overproduction of TSH, resulting in elevated thyroid hormone levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060203"
    }
  ],
  "roots": [
    {
      "id": 6233,
      "label": "hyperthyroidism"
    }
  ]
}