{
  "id": 29393,
  "label": "antiphospholipid syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:8000010",
  "properties": {
    "xrefs": [
      "DOID:2988",
      "EFO:0002689",
      "GARD:0005824",
      "ICD10CM:D68.61",
      "ICD9:279.49",
      "MEDGEN:38834",
      "MESH:D016736",
      "NCIT:C61283",
      "Orphanet:80",
      "SCTID:26843008",
      "UMLS:C0085278",
      "icd11.foundation:1173370808"
    ],
    "synonyms": [
      "Hughes syndrome",
      "antiphospholipid antibody syndrome",
      "antiphospholipid syndrome",
      "familial lupus anticoagulant",
      "lupus anticoagulant, familial"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A disorder caused by the presence of autoantibodies directed against phospholipids, causing a hypercoaguable state, which may result in blood clots, stroke, heart attack, and in women, significant pregnancy-related complications, including miscarriage and still birth. The syndrome is often associated with other autoimmune disorders, most commonly lupus erythematosus, and infections, including syphilis and Lyme disease."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 6922,
      "label": "primary antiphospholipid syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        29393
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024163",
          "ICD9:795.79",
          "MEDGEN:592740",
          "NANDO:1200267",
          "SCTID:239892009",
          "UMLS:C0409980",
          "icd11.foundation:85700944"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An antiphospholipid syndrome that occurs as an isolated disorder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005204"
    },
    {
      "id": 18707,
      "label": "catastrophic antiphospholipid syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        29393
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009820",
          "ICD9:289.81",
          "MEDGEN:783641",
          "NANDO:1200270",
          "Orphanet:464343",
          "SCTID:609329007",
          "UMLS:C3662487"
        ],
        "synonyms": [
          "CAPS",
          "caps",
          "catastrophic APS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018737"
    },
    {
      "id": 20262,
      "label": "secondary antiphospholipid syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29393
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025272",
          "ICD9:795.79",
          "MEDGEN:592743",
          "SCTID:239895006",
          "UMLS:C0409983",
          "icd11.foundation:138987181"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An antiphospholipid syndrome that occurs alongside another autoimmune disorder."
      },
      "child_count": 1,
      "reference_id": "MONDO:0021008"
    },
    {
      "id": 29397,
      "label": "familial antiphospholipid syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        29393
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027038",
          "MEDGEN:419641",
          "MESH:C531622",
          "OMIM:107320",
          "UMLS:C2930802"
        ],
        "synonyms": [
          "Hughes syndrome",
          "antiphospholipid syndrome, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Autosomal dominant form of antiphospholipid syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:8000014"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}