[ { "phenotype_id": "PH1024", "phenotype_version_id": 2257, "name": "Acute Myocardial Infarction (AMI)", "definition": "# Combining evidence across sources to define and date phenotypes\nIf there are records of non-ST elevation MI and ST elevation MI on the same date, the more severe diagnosis (STEMI) is taken as correct. If there is a record of unspecified MI and STEMI / NSTEMI on the same date, the non-specific diagnosis is ignored. MI may be recorded multiple times in the different datasets with slightly different dates. It is up to the researcher to decide what time interval should be used as a cut-off for considering that two events close to each other are distinct events rather than multuiple records of the same event; we would suggest 7 days because this is just greater than the usual duration of hospitalization for myocardial infarction.", "implementation": "", "publications": [ { "doi": "10.1371/journal.pone.0202344", "details": "Steele AJ et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS One. 2018 Aug 31;13(8):e0202344. doi: 10.1371/journal.pone.0202344. eCollection 2018. PMID: 30169498" }, { "doi": "10.1177/2047487318785228", "details": "Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2. PMID: 29966429" }, { "doi": "10.1002/ejhf.709", "details": "Koudstaal S et al. Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people. Eur J Heart Fail. 2017 Sep;19(9):1119-1127. doi: 10.1002/ejhf.709. Epub 2016 Dec 23. PMID: 28008698" }, { "doi": "10.1371/journal.pone.0202359", "details": "Chung SC et al. Time spent at blood pressure target and the risk of death and cardiovascular diseases. PLoS One. 2018 Sep 5;13(9):e0202359. doi: 10.1371/journal.pone.0202359. eCollection 2018. PMID: 30183734" }, { "doi": null, "details": "Bell S et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. PMID: 28331015" }, { "doi": "10.1093/eurheartj/ehw683", "details": "Pasea L et al. Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors. Eur Heart J. 2017 Apr 7;38(14):1048-1055. doi: 10.1093/eurheartj/ehw683. PMID: 28329300" }, { "doi": "10.1016/j.jacc.2016.12.022", "details": "Shah AD et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022. PMID: 28254179" }, { "doi": "10.1136/heartjnl-2015-308850", "details": "Asaria M et al. Using electronic health records to predict costs and outcomes in stable coronary artery disease. Heart. 2016 May 15;102(10):755-62. doi: 10.1136/heartjnl-2015-308850. Epub 2016 Feb 10. PMID: 26864674" }, { "doi": "10.1371/journal.pone.0153838", "details": "Daskalopoulou M et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016. PMID: 27105076" }, { "doi": "10.1136/heartjnl-2015-308514", "details": "Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818" }, { "doi": "10.1371/journal.pone.0151245", "details": "Pujades-Rodriguez M et al. Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245. eCollection 2016. PMID: 26978266" }, { "doi": "10.1136/openhrt-2016-000477", "details": "Shah AD et al. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016. PMID: 27621833" }, { "doi": null, "details": "Timmis A et al. Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations. BMJ. 2016 Jun 22;353:i3163. PMID: 27334486" }, { "doi": "10.1093/ehjqcco/qcw003", "details": "Walker S et al. Long-term healthcare use and costs in patients with stable coronary artery disease: a population-based cohort using linked health records (CALIBER). Eur Heart J Qual Care Clin Outcomes. 2016 Jan 20;2(2):125-140. doi: 10.1093/ehjqcco/qcw003. PMID: 27042338" }, { "doi": "10.1161/CIRCULATIONAHA.114.013797", "details": "George J et al. How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1. PMID: 26330414" }, { "doi": "10.1371/journal.pone.0110900", "details": "Morley KI et al. Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. PLoS One. 2014 Nov 4;9(11):e110900. doi: 10.1371/journal.pone.0110900. eCollection 2014. PMID: 25369203" }, { "doi": "10.1093/ije/dyu218", "details": "Pujades-Rodriguez M et al. Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20. PMID: 25416721" }, { "doi": "10.1371/journal.pone.0104671", "details": "Pujades-Rodriguez M et al. Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014. PMID: 25144739" }, { "doi": "10.1016/S0140-6736(14)60685-1", "details": "Rapsomaniki E et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1. PMID: 24881994" }, { "doi": "10.1016/S2213-8587(14)70219-0", "details": "Shah AD et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015 Feb;3(2):105-13. doi: 10.1016/S2213-8587(14)70219-0. Epub 2014 Nov 11. PMID: 25466521" }, { "doi": "10.1093/eurheartj/eht533", "details": "Rapsomaniki E et al. Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients. Eur Heart J. 2014 Apr;35(13):844-52. doi: 10.1093/eurheartj/eht533. Epub 2013 Dec 17. PMID: 24353280" } ], "validation": "casenote review, EHR sources, prognostic, genetic, cross-country", "citation_requirements": "", "created": "2022-08-23T11:24:05.471792Z", "author": "Julie George, Emily Herrett, Liam Smeeth, Harry Hemingway, Anoop Shah, Spiros Denaxas", "collections": [ { "name": "CALIBER", "value": 21 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-08-23T11:24:05.471815Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "HES Admitted Patient Care data for CPRD GOLD", "value": 9, "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43", "url": "https://healthdatagateway.org/en/dataset/674", "datasource_id": 674 }, { "name": "mortality data (ONS)", "value": 32, "uid": "", "url": "", "datasource_id": 32 } ], "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v2", "value": 5 }, { "name": "OPCS4 codes", "value": 7 }, { "name": "ICD9 codes", "value": 17 } ], "event_date_range": "01/01/1999 - 01/07/2016", "concept_information": [ { "concept_id": 3170, "concept_version_id": 8499, "concept_name": "File - Acute Myocardial Infarction - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH1024", "phenotype_version_id": 2257, "phenotype_name": "Acute Myocardial Infarction (AMI)", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "323..00", "description": "ECG: myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "3233", "description": "ECG: antero-septal infarct.", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "3234", "description": "ECG:posterior/inferior infarct", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "3235", "description": "ECG: subendocardial infarct", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "3236", "description": "ECG: lateral infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "323Z.00", "description": "ECG: myocardial infarct NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "889A.00", "description": "Diab mellit insulin-glucose infus acute myocardial infarct", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30..00", "description": "Acute myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G300.00", "description": "Acute anterolateral infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G301.00", "description": "Other specified anterior myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G301000", "description": "Acute anteroapical infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G301100", "description": "Acute anteroseptal infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30..12", "description": "Coronary thrombosis", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30..13", "description": "Cardiac rupture following myocardial infarction (MI)", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30..15", "description": "MI - acute myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30..16", "description": "Thrombosis - coronary", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G301z00", "description": "Anterior myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G302.00", "description": "Acute inferolateral infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G303.00", "description": "Acute inferoposterior infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G304.00", "description": "Posterior myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G305.00", "description": "Lateral myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G306.00", "description": "True posterior myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G307.00", "description": "Acute subendocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G307000", "description": "Acute non-Q wave infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G307100", "description": "Acute non-ST segment elevation myocardial infarction", "attributes": { "CALIBER.Category": "NSTEMI" } }, { "code": "G308.00", "description": "Inferior myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G309.00", "description": "Acute Q-wave infarct", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30B.00", "description": "Acute posterolateral myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30X.00", "description": "Acute transmural myocardial infarction of unspecif site", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30X000", "description": "Acute ST segment elevation myocardial infarction", "attributes": { "CALIBER.Category": "STEMI" } }, { "code": "G30y.00", "description": "Other acute myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30y000", "description": "Acute atrial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30y100", "description": "Acute papillary muscle infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30y200", "description": "Acute septal infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30yz00", "description": "Other acute myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G30z.00", "description": "Acute myocardial infarction NOS", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G31y100", "description": "Microinfarction of heart", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G38..00", "description": "Postoperative myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G380.00", "description": "Postoperative transmural myocardial infarction anterior wall", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G381.00", "description": "Postoperative transmural myocardial infarction inferior wall", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G384.00", "description": "Postoperative subendocardial myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "G38z.00", "description": "Postoperative myocardial infarction, unspecified", "attributes": { "CALIBER.Category": "Acute MI not further specified" } }, { "code": "Gyu3400", "description": "[X]Acute transmural myocardial infarction of unspecif site", "attributes": { "CALIBER.Category": "Acute MI not further specified" } } ] }, { "concept_id": 3171, "concept_version_id": 8501, "concept_name": "File - Acute Myocardial Infarction - Secondary Care - Diagnosis", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH1024", "phenotype_version_id": 2257, "phenotype_name": "Acute Myocardial Infarction (AMI)", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "CALIBER.Category": "Acute MI not further specified" } } ] }, { "concept_id": 3172, "concept_version_id": 8503, "concept_name": "File - Acute Myocardial Infarction - Secondary Care - Diagnosis", "coding_system": { "id": 7, "name": "OPCS4 codes", "description": "OPCS4 codes" }, "phenotype_id": "PH1024", "phenotype_version_id": 2257, "phenotype_name": "Acute Myocardial Infarction (AMI)", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "K50.2", "description": "Percutaneous transluminal coronary thrombolysis using streptokinase", "attributes": { "CALIBER.Category": "Transluminal coronary thrombolysis" } }, { "code": "K50.3", "description": "Percutaneous transluminal injection of therapeutic substance into coronary artery NEC", "attributes": { "CALIBER.Category": "Transluminal coronary thrombolysis" } } ] }, { "concept_id": 3173, "concept_version_id": 8505, "concept_name": "File - Acute Myocardial Infarction - Death - ICD9", "coding_system": { "id": 17, "name": "ICD9 codes", "description": "ICD9 codes" }, "phenotype_id": "PH1024", "phenotype_version_id": 2257, "phenotype_name": "Acute Myocardial Infarction (AMI)", "code_attribute_header": [ "category" ], "codes": [ { "code": "410", "description": "Acute myocardial infarction", "attributes": { "category": "Myocardial infarction" } }, { "code": "4110", "description": "Other acute and subacute forms of ischemic heart disease ; Postmyocardial infarction syndrome", "attributes": { "category": "Myocardial infarction" } }, { "code": "4297", "description": "Ill-defined descriptions and complications of heart disease ; Certain sequelae of myocardial infarction, not elsewhere classified", "attributes": { "category": "Myocardial infarction" } } ] }, { "concept_id": 3174, "concept_version_id": 8507, "concept_name": "File - Acute Myocardial Infarction - Death - ICD10", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH1024", "phenotype_version_id": 2257, "phenotype_name": "Acute Myocardial Infarction (AMI)", "code_attribute_header": [ "category" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "category": "Myocardial Infarction" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "category": "Myocardial Infarction" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "category": "Myocardial Infarction" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/w5r1-sy81", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 2257, "version_name": "Acute Myocardial Infarction (AMI)", "version_date": "2022-08-23T11:24:05.494443Z", "is_published": true, "is_latest": true } ] } ]