[
  {
    "phenotype_id": "PH1027",
    "phenotype_version_id": 2263,
    "name": "Coronary Heart Disease (CHD)",
    "definition": "Primary care\n1. Coronary heart disease not otherwise specified diagnosis during a consultation\nSecondary care\n1. Coronary heart disease not otherwise specified as the primary diagnosis for any hospitalization\nMortality\n1. Coronary heart disease not otherwise specified as the underlying cause of death",
    "implementation": "",
    "publications": [
      {
        "doi": "10.1371/journal.pone.0202344",
        "details": "Steele AJ et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS One. 2018 Aug 31;13(8):e0202344. doi: 10.1371/journal.pone.0202344. eCollection 2018. PMID: 30169498"
      },
      {
        "doi": "10.1177/2047487318785228",
        "details": "Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2. PMID: 29966429"
      },
      {
        "doi": "10.1002/ejhf.709",
        "details": "Koudstaal S et al. Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people. Eur J Heart Fail. 2017 Sep;19(9):1119-1127. doi: 10.1002/ejhf.709. Epub 2016 Dec 23. PMID: 28008698"
      },
      {
        "doi": "10.1371/journal.pone.0202359",
        "details": "Chung SC et al. Time spent at blood pressure target and the risk of death and cardiovascular diseases. PLoS One. 2018 Sep 5;13(9):e0202359. doi: 10.1371/journal.pone.0202359. eCollection 2018. PMID: 30183734"
      },
      {
        "doi": null,
        "details": "Bell S et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. PMID: 28331015"
      },
      {
        "doi": "10.1093/eurheartj/ehw683",
        "details": "Pasea L et al. Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors. Eur Heart J. 2017 Apr 7;38(14):1048-1055. doi: 10.1093/eurheartj/ehw683. PMID: 28329300"
      },
      {
        "doi": "10.1016/j.jacc.2016.12.022",
        "details": "Shah AD et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022. PMID: 28254179"
      },
      {
        "doi": "10.1136/heartjnl-2015-308850",
        "details": "Asaria M et al. Using electronic health records to predict costs and outcomes in stable coronary artery disease. Heart. 2016 May 15;102(10):755-62. doi: 10.1136/heartjnl-2015-308850. Epub 2016 Feb 10. PMID: 26864674"
      },
      {
        "doi": "10.1371/journal.pone.0153838",
        "details": "Daskalopoulou M et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016. PMID: 27105076"
      },
      {
        "doi": "10.1136/heartjnl-2015-308514",
        "details": "Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818"
      },
      {
        "doi": "10.1371/journal.pone.0151245",
        "details": "Pujades-Rodriguez M et al. Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245. eCollection 2016. PMID: 26978266"
      },
      {
        "doi": "10.1136/openhrt-2016-000477",
        "details": "Shah AD et al. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016. PMID: 27621833"
      },
      {
        "doi": null,
        "details": "Timmis A et al. Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations. BMJ. 2016 Jun 22;353:i3163. PMID: 27334486"
      },
      {
        "doi": "10.1093/ehjqcco/qcw003",
        "details": "Walker S et al. Long-term healthcare use and costs in patients with stable coronary artery disease: a population-based cohort using linked health records (CALIBER). Eur Heart J Qual Care Clin Outcomes. 2016 Jan 20;2(2):125-140. doi: 10.1093/ehjqcco/qcw003. PMID: 27042338"
      },
      {
        "doi": "10.1161/CIRCULATIONAHA.114.013797",
        "details": "George J et al. How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1. PMID: 26330414"
      },
      {
        "doi": "10.1371/journal.pone.0110900",
        "details": "Morley KI et al. Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. PLoS One. 2014 Nov 4;9(11):e110900. doi: 10.1371/journal.pone.0110900. eCollection 2014. PMID: 25369203"
      },
      {
        "doi": "10.1093/ije/dyu218",
        "details": "Pujades-Rodriguez M et al. Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20. PMID: 25416721"
      },
      {
        "doi": "10.1371/journal.pone.0104671",
        "details": "Pujades-Rodriguez M et al. Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014. PMID: 25144739"
      },
      {
        "doi": "10.1016/S0140-6736(14)60685-1",
        "details": "Rapsomaniki E et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1. PMID: 24881994"
      },
      {
        "doi": "10.1016/S2213-8587(14)70219-0",
        "details": "Shah AD et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015 Feb;3(2):105-13. doi: 10.1016/S2213-8587(14)70219-0. Epub 2014 Nov 11. PMID: 25466521"
      },
      {
        "doi": "10.1093/eurheartj/eht533",
        "details": "Rapsomaniki E et al. Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients. Eur Heart J. 2014 Apr;35(13):844-52. doi: 10.1093/eurheartj/eht533. Epub 2013 Dec 17. PMID: 24353280"
      }
    ],
    "validation": "prognostic, aetiologic",
    "citation_requirements": "",
    "created": "2022-08-23T11:27:17.005256Z",
    "author": "Julie George, Emily Herrett, Liam Smeeth, Harry Hemingway, Anoop Shah, Spiros Denaxas",
    "collections": [
      {
        "name": "CALIBER",
        "value": 21
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-08-23T11:27:17.005294Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "HES Admitted Patient Care data for CPRD GOLD",
        "value": 9,
        "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43",
        "url": "https://healthdatagateway.org/en/dataset/674",
        "datasource_id": 674
      },
      {
        "name": "mortality data (ONS)",
        "value": 32,
        "uid": "",
        "url": "",
        "datasource_id": 32
      }
    ],
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v2",
        "value": 5
      },
      {
        "name": "ICD9 codes",
        "value": 17
      }
    ],
    "event_date_range": "01/01/1999 - 01/07/2016",
    "concept_information": [
      {
        "concept_id": 3193,
        "concept_version_id": 8545,
        "concept_name": "File - Coronary Heart Disease - Primary Care - Incident",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH1027",
        "phenotype_version_id": 2263,
        "phenotype_name": "Coronary Heart Disease (CHD)",
        "code_attribute_header": [
          "CALIBER.Category"
        ],
        "codes": [
          {
            "code": "6A2..00",
            "description": "Coronary heart disease annual review",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "6A4..00",
            "description": "Coronary heart disease review",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "8B3k.00",
            "description": "Coronary heart disease medication review",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "8H2V.00",
            "description": "Admit ischaemic heart disease emergency",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3...00",
            "description": "Ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G31..00",
            "description": "Other acute and subacute ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3...11",
            "description": "Arteriosclerotic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G311000",
            "description": "Myocardial infarction aborted",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G311011",
            "description": "MI - myocardial infarction aborted",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3...12",
            "description": "Atherosclerotic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3...13",
            "description": "IHD - Ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G31y.00",
            "description": "Other acute and subacute ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G31y200",
            "description": "Subendocardial ischaemia",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G31y300",
            "description": "Transient myocardial ischaemia",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G31yz00",
            "description": "Other acute and subacute ischaemic heart disease NOS",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34..00",
            "description": "Other chronic ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G340.00",
            "description": "Coronary atherosclerosis",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G340.12",
            "description": "Coronary artery disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G343.00",
            "description": "Ischaemic cardiomyopathy",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G344.00",
            "description": "Silent myocardial ischaemia",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34y.00",
            "description": "Other specified chronic ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34y100",
            "description": "Chronic myocardial ischaemia",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34yz00",
            "description": "Other specified chronic ischaemic heart disease NOS",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34z.00",
            "description": "Other chronic ischaemic heart disease NOS",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G34z000",
            "description": "Asymptomatic coronary heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3y..00",
            "description": "Other specified ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "G3z..00",
            "description": "Ischaemic heart disease NOS",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "Gyu3.00",
            "description": "[X]Ischaemic heart diseases",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "Gyu3200",
            "description": "[X]Other forms of acute ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "Gyu3300",
            "description": "[X]Other forms of chronic ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          }
        ]
      },
      {
        "concept_id": 3194,
        "concept_version_id": 8547,
        "concept_name": "File - Coronary Heart Disease - Secondary Care",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1027",
        "phenotype_version_id": 2263,
        "phenotype_name": "Coronary Heart Disease (CHD)",
        "code_attribute_header": [
          "CALIBER.Category"
        ],
        "codes": [
          {
            "code": "I250",
            "description": "Atherosclerotic cardiovascular disease, so described",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I251",
            "description": "Atherosclerotic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I253",
            "description": "Aneurysm of heart",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I254",
            "description": "Coronary artery aneurysm",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I255",
            "description": "Ischaemic cardiomyopathy",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I256",
            "description": "Silent myocardial ischaemia",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I258",
            "description": "Other forms of chronic ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          },
          {
            "code": "I259",
            "description": "Chronic ischaemic heart disease, unspecified",
            "attributes": {
              "CALIBER.Category": "Diagnosed"
            }
          }
        ]
      },
      {
        "concept_id": 3195,
        "concept_version_id": 8549,
        "concept_name": "File - Coronary Heart Disease - Death",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1027",
        "phenotype_version_id": 2263,
        "phenotype_name": "Coronary Heart Disease (CHD)",
        "code_attribute_header": [
          "CALIBER.Category"
        ],
        "codes": [
          {
            "code": "I20",
            "description": "Angina pectoris",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          },
          {
            "code": "I21",
            "description": "Acute myocardial infarction",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          },
          {
            "code": "I22",
            "description": "Subsequent myocardial infarction",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          },
          {
            "code": "I23",
            "description": "Certain current complications following acute myocardial infarction",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          },
          {
            "code": "I24",
            "description": "Other acute ischaemic heart diseases",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          },
          {
            "code": "I25",
            "description": "Chronic ischaemic heart disease",
            "attributes": {
              "CALIBER.Category": "coronary_heart_disease"
            }
          }
        ]
      },
      {
        "concept_id": 3196,
        "concept_version_id": 8551,
        "concept_name": "File - Abdominal Aortic Aneurysm - Death",
        "coding_system": {
          "id": 17,
          "name": "ICD9 codes",
          "description": "ICD9 codes"
        },
        "phenotype_id": "PH1027",
        "phenotype_version_id": 2263,
        "phenotype_name": "Coronary Heart Disease (CHD)",
        "code_attribute_header": [
          "CALIBER.Category"
        ],
        "codes": [
          {
            "code": "410",
            "description": "Acute myocardial infarction",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "411",
            "description": "Other acute and subacute forms of ischemic heart disease",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "412",
            "description": "Old myocardial infarction",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "413",
            "description": "Angina pectoris",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "414",
            "description": "Other forms of chronic ischemic heart disease",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "4292",
            "description": "Ill-defined descriptions and complications of heart disease ; Cardiovascular disease, unspecified",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "4295",
            "description": "Ill-defined descriptions and complications of heart disease ; Rupture of chordae tendineae",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "4296",
            "description": "Ill-defined descriptions and complications of heart disease ; Rupture of papillary muscle",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          },
          {
            "code": "4297",
            "description": "Ill-defined descriptions and complications of heart disease ; Certain sequelae of myocardial infarction, not elsewhere classified",
            "attributes": {
              "CALIBER.Category": "Coronary heart disease"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/1mw8-6x73",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 2263,
        "version_name": "Coronary Heart Disease (CHD)",
        "version_date": "2022-08-23T11:27:17.033128Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]