[ { "phenotype_id": "PH1028", "phenotype_version_id": 2265, "name": "Heart Failure (fatal/non-fatal)", "definition": "# Combining evidence across sources to define and date phenotypes\nWe took the first occurring diagnosis code in primary, secondary care or the death registry to define the date, and clinical setting, of diagnosis. A prevalent case was defined as existing at or before the date of baseline; and incident case was defined as the new occurrence of a heart failure diagnosis code among people who, at baseline, did not have any previous diagnosis codes.\n![Flow chart diagram illustrating the CALIBER phenotype algorithm for heart failure.][images/hf_flowchart.png]\nFor identifying prevalent cases in primary care, we used a broader list of Read terms in addition to the case definition. While these terms alone did not provide sufficient certainty to identify incident cases, using them to exclude prevalent cases ensured that we removed any patient that had a historic or suspected HF diagnosis from the analysis.", "implementation": "", "publications": [ { "doi": "10.1371/journal.pone.0202344", "details": "Steele AJ et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS One. 2018 Aug 31;13(8):e0202344. doi: 10.1371/journal.pone.0202344. eCollection 2018. PMID: 30169498" }, { "doi": "10.1177/2047487318785228", "details": "Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2. PMID: 29966429" }, { "doi": "10.1002/ejhf.709", "details": "Koudstaal S et al. Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people. Eur J Heart Fail. 2017 Sep;19(9):1119-1127. doi: 10.1002/ejhf.709. Epub 2016 Dec 23. PMID: 28008698" }, { "doi": "10.1371/journal.pone.0202359", "details": "Chung SC et al. Time spent at blood pressure target and the risk of death and cardiovascular diseases. PLoS One. 2018 Sep 5;13(9):e0202359. doi: 10.1371/journal.pone.0202359. eCollection 2018. PMID: 30183734" }, { "doi": null, "details": "Bell S et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. PMID: 28331015" }, { "doi": "10.1093/eurheartj/ehw683", "details": "Pasea L et al. Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors. Eur Heart J. 2017 Apr 7;38(14):1048-1055. doi: 10.1093/eurheartj/ehw683. PMID: 28329300" }, { "doi": "10.1016/j.jacc.2016.12.022", "details": "Shah AD et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022. PMID: 28254179" }, { "doi": "10.1136/heartjnl-2015-308850", "details": "Asaria M et al. Using electronic health records to predict costs and outcomes in stable coronary artery disease. Heart. 2016 May 15;102(10):755-62. doi: 10.1136/heartjnl-2015-308850. Epub 2016 Feb 10. PMID: 26864674" }, { "doi": "10.1371/journal.pone.0153838", "details": "Daskalopoulou M et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016. PMID: 27105076" }, { "doi": "10.1136/heartjnl-2015-308514", "details": "Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818" }, { "doi": "10.1371/journal.pone.0151245", "details": "Pujades-Rodriguez M et al. Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245. eCollection 2016. PMID: 26978266" }, { "doi": "10.1136/openhrt-2016-000477", "details": "Shah AD et al. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016. PMID: 27621833" }, { "doi": null, "details": "Timmis A et al. Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations. BMJ. 2016 Jun 22;353:i3163. PMID: 27334486" }, { "doi": "10.1093/ehjqcco/qcw003", "details": "Walker S et al. Long-term healthcare use and costs in patients with stable coronary artery disease: a population-based cohort using linked health records (CALIBER). Eur Heart J Qual Care Clin Outcomes. 2016 Jan 20;2(2):125-140. doi: 10.1093/ehjqcco/qcw003. PMID: 27042338" }, { "doi": "10.1161/CIRCULATIONAHA.114.013797", "details": "George J et al. How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1. PMID: 26330414" }, { "doi": "10.1371/journal.pone.0110900", "details": "Morley KI et al. Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. PLoS One. 2014 Nov 4;9(11):e110900. doi: 10.1371/journal.pone.0110900. eCollection 2014. PMID: 25369203" }, { "doi": "10.1093/ije/dyu218", "details": "Pujades-Rodriguez M et al. Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20. PMID: 25416721" }, { "doi": "10.1371/journal.pone.0104671", "details": "Pujades-Rodriguez M et al. Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014. PMID: 25144739" }, { "doi": "10.1016/S0140-6736(14)60685-1", "details": "Rapsomaniki E et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1. PMID: 24881994" }, { "doi": "10.1016/S2213-8587(14)70219-0", "details": "Shah AD et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015 Feb;3(2):105-13. doi: 10.1016/S2213-8587(14)70219-0. Epub 2014 Nov 11. PMID: 25466521" }, { "doi": "10.1093/eurheartj/eht533", "details": "Rapsomaniki E et al. Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients. Eur Heart J. 2014 Apr;35(13):844-52. doi: 10.1093/eurheartj/eht533. Epub 2013 Dec 17. PMID: 24353280" } ], "validation": "EHR sources, Clinical, prognostic, Risk factors, casenote review, genetic, cross-country, prognostic, aetiologic", "citation_requirements": "", "created": "2022-08-23T11:28:51.234975Z", "author": "Koudstaal, S; Pujades-Rodriguez, M; Denaxas, S; Gho, JM; Shah, AD; Yu, N; Patel, RS; Gale, CP; Hoes, AW; Cleland, JG; Asselbergs, FW; Hemingway, H", "collections": [ { "name": "CALIBER", "value": 21 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-08-23T11:28:51.234999Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "HES Admitted Patient Care data for CPRD GOLD", "value": 9, "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43", "url": "https://healthdatagateway.org/en/dataset/674", "datasource_id": 674 }, { "name": "mortality data (ONS)", "value": 32, "uid": "", "url": "", "datasource_id": 32 } ], "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v2", "value": 5 }, { "name": "ICD9 codes", "value": 17 } ], "event_date_range": "01/01/1999 - 01/07/2016", "concept_information": [ { "concept_id": 3197, "concept_version_id": 8553, "concept_name": "File - Heart Failure - Primary Care - Incident - Diagnosis", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "1O1..00", "description": "Heart failure confirmed", "attributes": {} }, { "code": "662p.00", "description": "Heart failure 6 month review", "attributes": {} }, { "code": "662W.00", "description": "Heart failure annual review", "attributes": {} }, { "code": "8B29.00", "description": "Cardiac failure therapy", "attributes": {} }, { "code": "8H2S.00", "description": "Admit heart failure emergency", "attributes": {} }, { "code": "9Or0.00", "description": "Heart failure review completed", "attributes": {} }, { "code": "G1yz100", "description": "Rheumatic left ventricular failure", "attributes": {} }, { "code": "G210.00", "description": "Malignant hypertensive heart disease", "attributes": {} }, { "code": "G210000", "description": "Malignant hypertensive heart disease without CCF", "attributes": {} }, { "code": "G210100", "description": "Malignant hypertensive heart disease with CCF", "attributes": {} }, { "code": "G211100", "description": "Benign hypertensive heart disease with CCF", "attributes": {} }, { "code": "G21z100", "description": "Hypertensive heart disease NOS with CCF", "attributes": {} }, { "code": "G230.00", "description": "Malignant hypertensive heart and renal disease", "attributes": {} }, { "code": "G232.00", "description": "Hypertensive heart&renal dis wth (congestive) heart failure", "attributes": {} }, { "code": "G234.00", "description": "Hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": {} }, { "code": "G400.00", "description": "Acute cor pulmonale", "attributes": {} }, { "code": "G41z.11", "description": "Chronic cor pulmonale", "attributes": {} }, { "code": "G554000", "description": "Congestive cardiomyopathy", "attributes": {} }, { "code": "G554011", "description": "Congestive obstructive cardiomyopathy", "attributes": {} }, { "code": "G58..00", "description": "Heart failure", "attributes": {} }, { "code": "G580.00", "description": "Congestive heart failure", "attributes": {} }, { "code": "G580000", "description": "Acute congestive heart failure", "attributes": {} }, { "code": "G580100", "description": "Chronic congestive heart failure", "attributes": {} }, { "code": "G580.11", "description": "Congestive cardiac failure", "attributes": {} }, { "code": "G580.12", "description": "Right heart failure", "attributes": {} }, { "code": "G580.13", "description": "Right ventricular failure", "attributes": {} }, { "code": "G580.14", "description": "Biventricular failure", "attributes": {} }, { "code": "G580200", "description": "Decompensated cardiac failure", "attributes": {} }, { "code": "G580300", "description": "Compensated cardiac failure", "attributes": {} }, { "code": "G580400", "description": "Congestive heart failure due to valvular disease", "attributes": {} }, { "code": "G581.00", "description": "Left ventricular failure", "attributes": {} }, { "code": "G581000", "description": "Acute left ventricular failure", "attributes": {} }, { "code": "G58..11", "description": "Cardiac failure", "attributes": {} }, { "code": "G581.11", "description": "Asthma - cardiac", "attributes": {} }, { "code": "G581.13", "description": "Impaired left ventricular function", "attributes": {} }, { "code": "G582.00", "description": "Acute heart failure", "attributes": {} }, { "code": "G58z.00", "description": "Heart failure Not Otherwise Specified", "attributes": {} }, { "code": "G58z.12", "description": "Cardiac failure Not Otherwise Specified ", "attributes": {} }, { "code": "G5yy900", "description": "Left ventricular systolic dysfunction", "attributes": {} }, { "code": "G5yyA00", "description": "Left ventricular diastolic dysfunction", "attributes": {} }, { "code": "R2y1000", "description": "[D]Cardiorespiratory failure", "attributes": {} } ] }, { "concept_id": 3198, "concept_version_id": 8555, "concept_name": "File - Heart Failure - Primary Care - Incident - Abnormal Echocardiogram Findings", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "585f.00", "description": "Echocardiogram shows left ventricular systolic dysfunction", "attributes": {} }, { "code": "585g.00", "description": "Echocardiogram shows left ventricular diastolic dysfunction", "attributes": {} } ] }, { "concept_id": 3199, "concept_version_id": 8557, "concept_name": "File - Heart Failure - Primary Care - Prevalent", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "14A6.00", "description": "H/O: heart failure", "attributes": {} }, { "code": "14AM.00", "description": "H/O: Heart failure in last year", "attributes": {} }, { "code": "1736", "description": "Paroxysmal nocturnal dyspnoea", "attributes": {} }, { "code": "1J60.00", "description": "Suspected heart failure", "attributes": {} }, { "code": "23E1.00", "description": "O/E - pulmonary oedema", "attributes": {} }, { "code": "388D.00", "description": "New York Heart Assoc classification heart failure symptoms", "attributes": {} }, { "code": "662f.00", "description": "New York Heart Association classification - class I", "attributes": {} }, { "code": "662g.00", "description": "New York Heart Association classification - class II", "attributes": {} }, { "code": "662h.00", "description": "New York Heart Association classification - class III", "attributes": {} }, { "code": "662i.00", "description": "New York Heart Association classification - class IV", "attributes": {} }, { "code": "662T.00", "description": "Congestive heart failure monitoring", "attributes": {} }, { "code": "679X.00", "description": "Heart failure education", "attributes": {} }, { "code": "8CL3.00", "description": "Heart failure care plan discussed with patient", "attributes": {} }, { "code": "8HBE.00", "description": "Heart failure follow-up", "attributes": {} }, { "code": "8Hg8.00", "description": "Discharge from practice nurse heart failure clinic", "attributes": {} }, { "code": "8HHz.00", "description": "Referral to heart failure exercise programme", "attributes": {} }, { "code": "8Hk0.00", "description": "Referred to heart failure education group", "attributes": {} }, { "code": "9h1..00", "description": "Exception reporting: LVD quality indicators", "attributes": {} }, { "code": "9h11.00", "description": "Excepted from LVD quality indicators: Patient unsuitable", "attributes": {} }, { "code": "9h12.00", "description": "Excepted from LVD quality indicators: Informed dissent", "attributes": {} }, { "code": "9hH..00", "description": "Exception reporting: heart failure quality indicators", "attributes": {} }, { "code": "9hH0.00", "description": "Excepted heart failure quality indicators: Patient unsuitabl", "attributes": {} }, { "code": "9hH1.00", "description": "Excepted heart failure quality indicators: Informed dissent", "attributes": {} }, { "code": "9N0k.00", "description": "Seen in heart failure clinic", "attributes": {} }, { "code": "9N2p.00", "description": "Seen by community heart failure nurse", "attributes": {} }, { "code": "9N4s.00", "description": "Did not attend practice nurse heart failure clinic", "attributes": {} }, { "code": "9N4w.00", "description": "Did not attend heart failure clinic", "attributes": {} }, { "code": "9N6T.00", "description": "Referred by heart failure nurse specialist", "attributes": {} }, { "code": "9On..00", "description": "Left ventricular dysfunction monitoring administration", "attributes": {} }, { "code": "9On0.00", "description": "Left ventricular dysfunction monitoring first letter", "attributes": {} }, { "code": "9On1.00", "description": "Left ventricular dysfunction monitoring second letter", "attributes": {} }, { "code": "9On2.00", "description": "Left ventricular dysfunction monitoring third letter", "attributes": {} }, { "code": "9On3.00", "description": "Left ventricular dysfunction monitoring verbal invite", "attributes": {} }, { "code": "9On4.00", "description": "Left ventricular dysfunction monitoring telephone invite", "attributes": {} }, { "code": "9Or..00", "description": "Heart failure monitoring administration", "attributes": {} }, { "code": "9Or1.00", "description": "Heart failure monitoring telephone invite", "attributes": {} }, { "code": "9Or2.00", "description": "Heart failure monitoring verbal invite", "attributes": {} }, { "code": "9Or3.00", "description": "Heart failure monitoring first letter", "attributes": {} }, { "code": "9Or4.00", "description": "Heart failure monitoring second letter", "attributes": {} }, { "code": "9Or5.00", "description": "Heart failure monitoring third letter", "attributes": {} }, { "code": "G581.12", "description": "Pulmonary oedema - acute", "attributes": {} }, { "code": "G58z.11", "description": "Weak heart", "attributes": {} }, { "code": "H54..00", "description": "Pulmonary congestion and hypostasis", "attributes": {} }, { "code": "H541.00", "description": "Pulmonary congestion", "attributes": {} }, { "code": "H541000", "description": "Chronic pulmonary oedema", "attributes": {} }, { "code": "H541z00", "description": "Pulmonary oedema NOS", "attributes": {} }, { "code": "H54z.00", "description": "Pulmonary congestion and hypostasis NOS", "attributes": {} }, { "code": "H584.00", "description": "Acute pulmonary oedema unspecified", "attributes": {} }, { "code": "H584z00", "description": "Acute pulmonary oedema NOS", "attributes": {} }, { "code": "ZRad.00", "description": "New York Heart Assoc classification heart failure symptoms", "attributes": {} } ] }, { "concept_id": 3200, "concept_version_id": 8559, "concept_name": "File - Coronary Heart Disease - Secondary Care", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": {} }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": {} }, { "code": "I32.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": {} }, { "code": "I50.0", "description": "Congestive heart failure", "attributes": {} }, { "code": "I50.1", "description": "Left ventricular heart failure", "attributes": {} }, { "code": "I50.9", "description": "Heart failure, unspecified", "attributes": {} } ] }, { "concept_id": 3201, "concept_version_id": 8561, "concept_name": "File - Coronary Heart Disease - Death", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "I11.0", "description": "Hypertensive heart disease with (congestive) heart failure", "attributes": {} }, { "code": "I13.0", "description": "Hypertensive heart and renal disease with (congestive) heart failure", "attributes": {} }, { "code": "I32.2", "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": {} }, { "code": "I50.0", "description": "Congestive heart failure", "attributes": {} }, { "code": "I50.1", "description": "Left ventricular heart failure", "attributes": {} }, { "code": "I50.9", "description": "Heart failure, unspecified", "attributes": {} } ] }, { "concept_id": 3202, "concept_version_id": 8563, "concept_name": "File - Coronary Heart Disease - Death", "coding_system": { "id": 17, "name": "ICD9 codes", "description": "ICD9 codes" }, "phenotype_id": "PH1028", "phenotype_version_id": 2265, "phenotype_name": "Heart Failure (fatal/non-fatal)", "code_attribute_header": [], "codes": [ { "code": "428", "description": "Congestive heart failure, unspecified", "attributes": {} }, { "code": "428.1", "description": "Left heart failure", "attributes": {} }, { "code": "428.9", "description": "Heart failure, unspecified", "attributes": {} } ] } ], "status": 2, "doi": "https://doi.org/10.48533/hmf7-em52", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 2265, "version_name": "Heart Failure (fatal/non-fatal)", "version_date": "2022-08-23T11:28:51.255371Z", "is_published": true, "is_latest": true } ] } ]