[ { "phenotype_id": "PH1029", "phenotype_version_id": 2267, "name": "Hypertension", "definition": "# Combining evidence across sources to define and date phenotypes\nHT is defined as either a explicit diagnosis in primary or secondary care, or implicity based on blood pressure readings or prescription of blood pressure controll medications in primary care.", "implementation": "", "publications": [ { "doi": "10.1371/journal.pone.0202344", "details": "Steele AJ et al. Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease. PLoS One. 2018 Aug 31;13(8):e0202344. doi: 10.1371/journal.pone.0202344. eCollection 2018. PMID: 30169498" }, { "doi": "10.1177/2047487318785228", "details": "Archangelidi O et al. Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study. Eur J Prev Cardiol. 2018 Sep;25(14):1485-1495. doi: 10.1177/2047487318785228. Epub 2018 Jul 2. PMID: 29966429" }, { "doi": "10.1002/ejhf.709", "details": "Koudstaal S et al. Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people. Eur J Heart Fail. 2017 Sep;19(9):1119-1127. doi: 10.1002/ejhf.709. Epub 2016 Dec 23. PMID: 28008698" }, { "doi": "10.1371/journal.pone.0202359", "details": "Chung SC et al. Time spent at blood pressure target and the risk of death and cardiovascular diseases. PLoS One. 2018 Sep 5;13(9):e0202359. doi: 10.1371/journal.pone.0202359. eCollection 2018. PMID: 30183734" }, { "doi": null, "details": "Bell S et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017 Mar 22;356:j909. PMID: 28331015" }, { "doi": "10.1093/eurheartj/ehw683", "details": "Pasea L et al. Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors. Eur Heart J. 2017 Apr 7;38(14):1048-1055. doi: 10.1093/eurheartj/ehw683. PMID: 28329300" }, { "doi": "10.1016/j.jacc.2016.12.022", "details": "Shah AD et al. Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study. J Am Coll Cardiol. 2017 Mar 7;69(9):1160-1169. doi: 10.1016/j.jacc.2016.12.022. PMID: 28254179" }, { "doi": "10.1136/heartjnl-2015-308850", "details": "Asaria M et al. Using electronic health records to predict costs and outcomes in stable coronary artery disease. Heart. 2016 May 15;102(10):755-62. doi: 10.1136/heartjnl-2015-308850. Epub 2016 Feb 10. PMID: 26864674" }, { "doi": "10.1371/journal.pone.0153838", "details": "Daskalopoulou M et al. Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. PLoS One. 2016 Apr 22;11(4):e0153838. doi: 10.1371/journal.pone.0153838. eCollection 2016. PMID: 27105076" }, { "doi": "10.1136/heartjnl-2015-308514", "details": "Pujades-Rodriguez M et al. Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases. Heart. 2016 Mar;102(5):383-9. doi: 10.1136/heartjnl-2015-308514. Epub 2016 Jan 19. PMID: 26786818" }, { "doi": "10.1371/journal.pone.0151245", "details": "Pujades-Rodriguez M et al. Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England. PLoS One. 2016 Mar 15;11(3):e0151245. doi: 10.1371/journal.pone.0151245. eCollection 2016. PMID: 26978266" }, { "doi": "10.1136/openhrt-2016-000477", "details": "Shah AD et al. Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study. Open Heart. 2016 Sep 5;3(2):e000477. doi: 10.1136/openhrt-2016-000477. eCollection 2016. PMID: 27621833" }, { "doi": null, "details": "Timmis A et al. Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations. BMJ. 2016 Jun 22;353:i3163. PMID: 27334486" }, { "doi": "10.1093/ehjqcco/qcw003", "details": "Walker S et al. Long-term healthcare use and costs in patients with stable coronary artery disease: a population-based cohort using linked health records (CALIBER). Eur Heart J Qual Care Clin Outcomes. 2016 Jan 20;2(2):125-140. doi: 10.1093/ehjqcco/qcw003. PMID: 27042338" }, { "doi": "10.1161/CIRCULATIONAHA.114.013797", "details": "George J et al. How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People. Circulation. 2015 Oct 6;132(14):1320-8. doi: 10.1161/CIRCULATIONAHA.114.013797. Epub 2015 Sep 1. PMID: 26330414" }, { "doi": "10.1371/journal.pone.0110900", "details": "Morley KI et al. Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. PLoS One. 2014 Nov 4;9(11):e110900. doi: 10.1371/journal.pone.0110900. eCollection 2014. PMID: 25369203" }, { "doi": "10.1093/ije/dyu218", "details": "Pujades-Rodriguez M et al. Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction. Int J Epidemiol. 2015 Feb;44(1):129-41. doi: 10.1093/ije/dyu218. Epub 2014 Nov 20. PMID: 25416721" }, { "doi": "10.1371/journal.pone.0104671", "details": "Pujades-Rodriguez M et al. Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention. PLoS One. 2014 Aug 21;9(8):e104671. doi: 10.1371/journal.pone.0104671. eCollection 2014. PMID: 25144739" }, { "doi": "10.1016/S0140-6736(14)60685-1", "details": "Rapsomaniki E et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 2014 May 31;383(9932):1899-911. doi: 10.1016/S0140-6736(14)60685-1. PMID: 24881994" }, { "doi": "10.1016/S2213-8587(14)70219-0", "details": "Shah AD et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015 Feb;3(2):105-13. doi: 10.1016/S2213-8587(14)70219-0. Epub 2014 Nov 11. PMID: 25466521" }, { "doi": "10.1093/eurheartj/eht533", "details": "Rapsomaniki E et al. Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients. Eur Heart J. 2014 Apr;35(13):844-52. doi: 10.1093/eurheartj/eht533. Epub 2013 Dec 17. PMID: 24353280" } ], "validation": "prognostic, aetiologic", "citation_requirements": "", "created": "2022-08-23T11:29:48.434067Z", "author": "Julie George, Emily Herrett, Liam Smeeth, Harry Hemingway, Anoop Shah, Spiros Denaxas", "collections": [ { "name": "CALIBER", "value": 21 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-08-23T11:29:48.434117Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "HES Admitted Patient Care data for CPRD GOLD", "value": 9, "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43", "url": "https://healthdatagateway.org/en/dataset/674", "datasource_id": 674 } ], "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v2", "value": 5 }, { "name": "ICD9 codes", "value": 17 } ], "event_date_range": "01/01/1999 - 01/07/2016", "concept_information": [ { "concept_id": 3203, "concept_version_id": 8565, "concept_name": "File - Hypertension - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH1029", "phenotype_version_id": 2267, "phenotype_name": "Hypertension", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "6146200", "description": "Hypertension induced by oral contraceptive pill", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "6624", "description": "Borderline hyperten:yearly obs", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "6627", "description": "Good hypertension control", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "6628", "description": "Poor hypertension control", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662b.00", "description": "Moderate hypertension control", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662c.00", "description": "Hypertension six month review", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662d.00", "description": "Hypertension annual review", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662F.00", "description": "Hypertension treatm. started", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662G.00", "description": "Hypertensive treatm.changed", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662O.00", "description": "On treatment for hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "662r.00", "description": "Trial withdrawal of antihypertensive therapy", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "7Q01.00", "description": "High cost hypertension drugs", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "8B26.00", "description": "Antihypertensive therapy", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "8BL0.00", "description": "Patient on maximal tolerated antihypertensive therapy", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "8I3N.00", "description": "Hypertension treatment refused", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "F404200", "description": "Blind hypertensive eye", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "F421300", "description": "Hypertensive retinopathy", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G2...00", "description": "Hypertensive disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G20..00", "description": "Essential hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G200.00", "description": "Malignant essential hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G201.00", "description": "Benign essential hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G202.00", "description": "Systolic hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G203.00", "description": "Diastolic hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G20z.00", "description": "Essential hypertension NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G20z.11", "description": "Hypertension NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21..00", "description": "Hypertensive heart disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G210.00", "description": "Malignant hypertensive heart disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G210000", "description": "Malignant hypertensive heart disease without CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G210100", "description": "Malignant hypertensive heart disease with CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G2...11", "description": "BP - hypertensive disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G211.00", "description": "Benign hypertensive heart disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G211000", "description": "Benign hypertensive heart disease without CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G211100", "description": "Benign hypertensive heart disease with CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21z.00", "description": "Hypertensive heart disease NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21z000", "description": "Hypertensive heart disease NOS without CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21z011", "description": "Cardiomegaly - hypertensive", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21z100", "description": "Hypertensive heart disease NOS with CCF", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G21zz00", "description": "Hypertensive heart disease NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G22..00", "description": "Hypertensive renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G220.00", "description": "Malignant hypertensive renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G221.00", "description": "Benign hypertensive renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G222.00", "description": "Hypertensive renal disease with renal failure", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G22z.00", "description": "Hypertensive renal disease NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G22z.11", "description": "Renal hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G23..00", "description": "Hypertensive heart and renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G230.00", "description": "Malignant hypertensive heart and renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G231.00", "description": "Benign hypertensive heart and renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G232.00", "description": "Hypertensive heart&renal dis wth (congestive) heart failure", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G233.00", "description": "Hypertensive heart and renal disease with renal failure", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G234.00", "description": "Hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G23z.00", "description": "Hypertensive heart and renal disease NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G24..00", "description": "Secondary hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G240.00", "description": "Secondary malignant hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G240000", "description": "Secondary malignant renovascular hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G240z00", "description": "Secondary malignant hypertension NOS", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G241.00", "description": "Secondary benign hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G241000", "description": "Secondary benign renovascular hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G241z00", "description": "Secondary benign hypertension NOS", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G244.00", "description": "Hypertension secondary to endocrine disorders", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G24z.00", "description": "Secondary hypertension NOS", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G24z000", "description": "Secondary renovascular hypertension NOS", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G24z100", "description": "Hypertension secondary to drug", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G24zz00", "description": "Secondary hypertension NOS", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "G2y..00", "description": "Other specified hypertensive disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G2z..00", "description": "Hypertensive disease NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G672.00", "description": "Hypertensive encephalopathy", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "G672.11", "description": "Hypertensive crisis", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "Gyu2.00", "description": "[X]Hypertensive diseases", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "Gyu2100", "description": "[X]Hypertension secondary to other renal disorders", "attributes": { "CALIBER.Category": "Secondary hypertension" } }, { "code": "L122.00", "description": "Other pre-existing hypertension in preg/childbirth/puerp", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L122000", "description": "Other pre-existing hypertension in preg/childb/puerp unspec", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L122100", "description": "Other pre-existing hypertension in preg/childb/puerp - deliv", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L122300", "description": "Other pre-exist hypertension in preg/childb/puerp-not deliv", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L122z00", "description": "Other pre-existing hypertension in preg/childb/puerp NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L127.00", "description": "Pre-eclampsia or eclampsia with pre-existing hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L127z00", "description": "Pre-eclampsia or eclampsia + pre-existing hypertension NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L128.00", "description": "Pre-exist hypertension compl preg childbirth and puerperium", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L128000", "description": "Pre-exist hyperten heart dis compl preg childbth+puerperium", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "L128200", "description": "Pre-exist 2ndry hypertens comp preg childbth and puerperium", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "TJC7.00", "description": "Adverse reaction to other antihypertensives", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "TJC7z00", "description": "Adverse reaction to antihypertensives NOS", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "U60C500", "description": "[X]Oth antihyperten drug caus advers eff in therap use, NEC", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "U60C511", "description": "[X] Adverse reaction to other antihypertensives", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "U60C51A", "description": "[X] Adverse reaction to antihypertensives NOS", "attributes": { "CALIBER.Category": "Hypertension" } } ] }, { "concept_id": 3204, "concept_version_id": 8567, "concept_name": "File - Coronary Heart Disease - Secondary Care", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH1029", "phenotype_version_id": 2267, "phenotype_name": "Hypertension", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "I10", "description": "Essential (primary) hypertension", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "I11", "description": "Hypertensive heart disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "I12", "description": "Hypertensive renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "I13", "description": "Hypertensive heart and renal disease", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "I15", "description": "Secondary hypertension", "attributes": { "CALIBER.Category": "Secondary hypertension" } } ] }, { "concept_id": 3205, "concept_version_id": 8569, "concept_name": "File - Coronary Heart Disease - Secondary Care", "coding_system": { "id": 17, "name": "ICD9 codes", "description": "ICD9 codes" }, "phenotype_id": "PH1029", "phenotype_version_id": 2267, "phenotype_name": "Hypertension", "code_attribute_header": [ "CALIBER.Category" ], "codes": [ { "code": "X82.8", "description": "Other specified high cost hypertension drugs", "attributes": { "CALIBER.Category": "Hypertension" } }, { "code": "X82.9", "description": "Unspecified high cost hypertension drugs", "attributes": { "CALIBER.Category": "Hypertension" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/783z-df51", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 2267, "version_name": "Hypertension", "version_date": "2022-08-23T11:29:48.462558Z", "is_published": true, "is_latest": true } ] } ]