[
  {
    "phenotype_id": "PH116",
    "phenotype_version_id": 232,
    "name": "Vitamin B12 deficiency anaemia",
    "definition": "At the specified date, a patient is defined as having had 'Vitamin B12 deficiency anaemia' IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:\n\n\nPrimary care\n\n\n1. 'Vitamin B12 deficiency anaemia' diagnosis or history of diagnosis during a consultation \n\nOR\nSecondary care (ICD10)\n\n\n1. ALL diagnoses of 'Vitamin B12 deficiency anaemia' or history of diagnosis during a hospitalization\n\n\n\n\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": "10.1016/S2589-7500(19)30012-3",
        "details": "Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3"
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:03:43.323508Z",
    "author": "Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A",
    "collections": [
      {
        "name": "CALIBER",
        "value": 21
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:03:43.323538Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "https://kclhi.org/phenoflow/workflows/github.com/phenoflow/Vitamin-B12-deficiency-anaemia---50205780-1764-11ef-9de4-4d4ea830ad16/blob/read-potential-cases-fhir/Vitamin-B12-deficiency-anaemia.cwl",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      },
      {
        "name": "HES Admitted Patient Care data for CPRD GOLD",
        "value": 9,
        "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43",
        "url": "https://healthdatagateway.org/en/dataset/674",
        "datasource_id": 674
      }
    ],
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v2",
        "value": 5
      },
      {
        "name": "Med codes",
        "value": 8
      }
    ],
    "event_date_range": "01/01/1999 - 01/07/2016",
    "concept_information": [
      {
        "concept_id": 1013,
        "concept_version_id": 3165,
        "concept_name": "Vitamin B12 deficiency anaemia - Primary care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH116",
        "phenotype_version_id": 232,
        "phenotype_name": "Vitamin B12 deficiency anaemia",
        "code_attribute_header": [
          "Disease",
          "Medcode",
          "Category"
        ],
        "codes": [
          {
            "code": "1452",
            "description": "H/O: Anaemia vit.B12 deficient",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "54738",
              "Category": "History of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "66E..00",
            "description": "B12 deficiency monitoring",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "7403",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E1.00",
            "description": "B12 defic. initial assessment",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "11126",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E2.00",
            "description": "B12 defic.follow-up assessment",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "8013",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E3.00",
            "description": "B12 injections started",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "31126",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E4.00",
            "description": "B12 injections - at home",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "42928",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E5.00",
            "description": "B12 injections - at surgery",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "12329",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E6.00",
            "description": "Reticulcytosis after B12",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "66935",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "66E7.00",
            "description": "B12 def.-dubious diag.criteria",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "48714",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66E8.00",
            "description": "B12 injections stopped",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "58599",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "66EZ.00",
            "description": "B12 defic. monitoring NOS",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "36840",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "C262100",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "2515",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "D010.00",
            "description": "Pernicious anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "2464",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D010.11",
            "description": "Addison's anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "2813",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D010.12",
            "description": "Biermer's congenital pernicious anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "55370",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D010.13",
            "description": "Congenital deficiency of intrinsic factor",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "46289",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011.00",
            "description": "Other vitamin B12 deficiency anaemias",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "29486",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011000",
            "description": "Vitamin B12 deficiency anaemia due to dietary causes",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "32953",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011011",
            "description": "Imerslund - Grasbeck syndrome",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "72895",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011013",
            "description": "Vegan's anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "69275",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011100",
            "description": "Vit B12 defic anaemia due to malabsorption with proteinuria",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "2482",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011.11",
            "description": "Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "5271",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011200",
            "description": "Transcobalamin II deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "62637",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011X00",
            "description": "Vitamin B12 deficiency anaemia, unspecified",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "6028",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D011z00",
            "description": "Other vitamin B12 deficiency anaemia NOS",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "31270",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "D013000",
            "description": "Combined B12 and folate deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "22715",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "Dyu0100",
            "description": "[X]Other dietary vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "47952",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "Dyu0200",
            "description": "[X]Other vitamin B12 deficiency anaemias",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "35092",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "Dyu0600",
            "description": "[X]Vitamin B12 deficiency anaemia, unspecified",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "53846",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          },
          {
            "code": "F11x600",
            "description": "Cerebral degeneration due to vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "24581",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "F162.00",
            "description": "Subacute combined degeneration of spinal cord",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "7736",
              "Category": "Vitamin B12 deficiency"
            }
          },
          {
            "code": "F381500",
            "description": "Myasthenic syndrome due to pernicious anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Medcode": "56973",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          }
        ]
      },
      {
        "concept_id": 1014,
        "concept_version_id": 3167,
        "concept_name": "Vitamin B12 deficiency anaemia - Primary care",
        "coding_system": {
          "id": 8,
          "name": "Med codes",
          "description": "Med codes"
        },
        "phenotype_id": "PH116",
        "phenotype_version_id": 232,
        "phenotype_name": "Vitamin B12 deficiency anaemia",
        "code_attribute_header": [
          "Disease",
          "ReadcodeDescr",
          "Readcode"
        ],
        "codes": [
          {
            "code": "11126",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 defic. initial assessment",
              "Readcode": "66E1.00"
            }
          },
          {
            "code": "12329",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 injections - at surgery",
              "Readcode": "66E5.00"
            }
          },
          {
            "code": "22715",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Combined B12 and folate deficiency anaemia",
              "Readcode": "D013000"
            }
          },
          {
            "code": "24581",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Cerebral degeneration due to vitamin B12 deficiency",
              "Readcode": "F11x600"
            }
          },
          {
            "code": "2464",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Pernicious anaemia",
              "Readcode": "D010.00"
            }
          },
          {
            "code": "2482",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vit B12 defic anaemia due to malabsorption with proteinuria",
              "Readcode": "D011100"
            }
          },
          {
            "code": "2515",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vitamin B12 deficiency",
              "Readcode": "C262100"
            }
          },
          {
            "code": "2813",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Addison's anaemia",
              "Readcode": "D010.11"
            }
          },
          {
            "code": "29486",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Other vitamin B12 deficiency anaemias",
              "Readcode": "D011.00"
            }
          },
          {
            "code": "31126",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 injections started",
              "Readcode": "66E3.00"
            }
          },
          {
            "code": "31270",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Other vitamin B12 deficiency anaemia NOS",
              "Readcode": "D011z00"
            }
          },
          {
            "code": "32953",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vitamin B12 deficiency anaemia due to dietary causes",
              "Readcode": "D011000"
            }
          },
          {
            "code": "35092",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "[X]Other vitamin B12 deficiency anaemias",
              "Readcode": "Dyu0200"
            }
          },
          {
            "code": "36840",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 defic. monitoring NOS",
              "Readcode": "66EZ.00"
            }
          },
          {
            "code": "42928",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 injections - at home",
              "Readcode": "66E4.00"
            }
          },
          {
            "code": "46289",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Congenital deficiency of intrinsic factor",
              "Readcode": "D010.13"
            }
          },
          {
            "code": "47952",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "[X]Other dietary vitamin B12 deficiency anaemia",
              "Readcode": "Dyu0100"
            }
          },
          {
            "code": "48714",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 def.-dubious diag.criteria",
              "Readcode": "66E7.00"
            }
          },
          {
            "code": "5271",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vitamin B12 deficiency anaemia",
              "Readcode": "D011.11"
            }
          },
          {
            "code": "53846",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "[X]Vitamin B12 deficiency anaemia, unspecified",
              "Readcode": "Dyu0600"
            }
          },
          {
            "code": "54738",
            "description": "History of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "H/O: Anaemia vit.B12 deficient",
              "Readcode": "1452"
            }
          },
          {
            "code": "55370",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Biermer's congenital pernicious anaemia",
              "Readcode": "D010.12"
            }
          },
          {
            "code": "56973",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Myasthenic syndrome due to pernicious anaemia",
              "Readcode": "F381500"
            }
          },
          {
            "code": "58599",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 injections stopped",
              "Readcode": "66E8.00"
            }
          },
          {
            "code": "6028",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vitamin B12 deficiency anaemia, unspecified",
              "Readcode": "D011X00"
            }
          },
          {
            "code": "62637",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Transcobalamin II deficiency",
              "Readcode": "D011200"
            }
          },
          {
            "code": "66935",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Reticulcytosis after B12",
              "Readcode": "66E6.00"
            }
          },
          {
            "code": "69275",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Vegan's anaemia",
              "Readcode": "D011013"
            }
          },
          {
            "code": "72895",
            "description": "Diagnosis of Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Imerslund - Grasbeck syndrome",
              "Readcode": "D011011"
            }
          },
          {
            "code": "7403",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 deficiency monitoring",
              "Readcode": "66E..00"
            }
          },
          {
            "code": "7736",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "Subacute combined degeneration of spinal cord",
              "Readcode": "F162.00"
            }
          },
          {
            "code": "8013",
            "description": "Vitamin B12 deficiency",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "ReadcodeDescr": "B12 defic.follow-up assessment",
              "Readcode": "66E2.00"
            }
          }
        ]
      },
      {
        "concept_id": 1015,
        "concept_version_id": 3169,
        "concept_name": "Vitamin B12 deficiency anaemia - Secondary care - Diagnoses",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH116",
        "phenotype_version_id": 232,
        "phenotype_name": "Vitamin B12 deficiency anaemia",
        "code_attribute_header": [
          "Disease",
          "Category"
        ],
        "codes": [
          {
            "code": "D51",
            "description": "Vitamin B12 deficiency anaemia",
            "attributes": {
              "Disease": "Vitamin B12 deficiency anaemia",
              "Category": "Diagnosis of Vitamin B12 deficiency anaemia"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/7yv6-sd72",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 232,
        "version_name": "Vitamin B12 deficiency anaemia",
        "version_date": "2021-10-06T16:03:43.351166Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]