[
  {
    "phenotype_id": "PH1657",
    "phenotype_version_id": 3432,
    "name": "Charlson comorbidity index (Quan 2011)",
    "definition": "The Charlson comorbidity index (CCI), modified by Quan et al., includes comorbidities used to predict mortality risk and healthcare utilisation. The updated index of 12 comorbidities (17 when stratified by severity) showed good-to-excellent discrimination in predicting in-hospital mortality in data from 6 countries and may be appropriate for use with more recent administrative data.\n\n[ICD-10 codes](https://github.com/ellessenne/comorbidity/blob/master/data-raw/make-mapping.R) and condition [weightings](https://github.com/ellessenne/comorbidity/blob/master/data-raw/make-weights.R) were obtained from the source code of the \"comorbidity\" R package.\n\n**References**\n\n- Hude Quan, Bing Li, Chantal M. Couris, Kiyohide Fushimi, Patrick Graham, Phil Hider, Jean-Marie Januel, Vijaya Sundararajan, Updating and Validating the Charlson Comorbidity Index and Score for Risk Adjustment in Hospital Discharge Abstracts Using Data From 6 Countries, American Journal of Epidemiology, Volume 173, Issue 6, 15 March 2011, Pages 676–682, https://doi.org/10.1093/aje/kwq433\n\n- Gasparini, (2018). comorbidity: An R package for computing comorbidity scores. Journal of Open Source Software, 3(23), 648, https://doi.org/10.21105/joss.00648",
    "implementation": "**CCI Scoring System**\n\nThe conditions have the following weightings:\n\n1. Myocardial infarction: 0\n\n2. Congestive heart failure: 2\n\n3. Peripheral vascular disease: 0\n\n4. Cerebrovascular disease: 0\n\n5. Dementia: 2\n\n6. Chronic pulmonary disease: 1\n\n7. Rheumatologic disease: 1\n\n8. Peptic ulcer disease: 0\n\n9. Hemiplegia/ paraplegia: 2\n\n10. Diabetes without complications: 0\n\n11. Diabetes with chronic complications: 1\n\n12. Mild liver disease: 2\n\n13. Moderate/severe liver disease: 4\n\n14. Renal disease: 1\n\n15. Malignancy (tumor, leukemia, lymphoma): 2\n\n16. Metastatic solid tumor: 6\n\n17. HIV/AIDS: 4\n\n**Hierarchy Categories**\n\nWithin each hierarchy category, the milder condition should not contribute to the CCI score if a more severe condition is present, even though codes for both may appear for an individual patient.\n\n1. \"Diabetes with chronic complications\" (Condition 11) trumps \"Diabetes without complications\" (Condition 10)\n\n2. \"Moderate/severe liver disease\" (Condition 13) trumps \"Mild liver disease\" (Condition 12)\n\n3. \"Metastatic solid tumor\" (Condition 16) trumps \"Malignancy\" (Condition 15)",
    "publications": [
      {
        "doi": "10.1093/aje/kwq433",
        "details": "Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, Januel JM, Sundararajan V. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011 Mar 15;173(6):676-82. doi: 10.1093/aje/kwq433. Epub 2011 Feb 17. PMID: 21330339."
      },
      {
        "doi": "10.21105/joss.00648",
        "details": "Gasparini, (2018). comorbidity: An R package for computing comorbidity scores. Journal of Open Source Software, 3(23), 648, https://doi.org/10.21105/joss.00648"
      },
      {
        "doi": "10.1136/bmjopen-2020-041302",
        "details": "Hedetoft M, Madsen MB, Madsen LB, et alIncidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005–2018: a Danish nationwide register-based cohort studyBMJ Open 2020;10:e041302. doi: 10.1136/bmjopen-2020-041302"
      }
    ],
    "validation": "",
    "citation_requirements": "Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, Januel JM, Sundararajan V. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011 Mar 15;173(6):676-82. doi: 10.1093/aje/kwq433. Epub 2011 Feb 17. PMID: 21330339.",
    "created": "2024-06-25T20:03:15.824346Z",
    "author": "Hude Quan, Bing Li, Chantal M. Couris, Kiyohide Fushimi, Patrick Graham, Phil Hider, Jean-Marie Januel, Vijaya Sundararajan",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      }
    ],
    "tags": [
      {
        "name": "Comorbidity Index",
        "value": 29
      }
    ],
    "organisation": {
      "id": 13,
      "slug": "bhf-data-science-centre",
      "name": "BHF Data Science Centre"
    },
    "world_access": 2,
    "updated": "2024-06-25T21:01:22.852536Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": null,
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "Hospital Episode Statistics Admitted Patient Care",
        "value": 2,
        "uid": "6599230a-df54-4615-937c-d724d239491f",
        "url": "https://healthdatagateway.org/en/dataset/875",
        "datasource_id": 875
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": null,
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 3626,
        "concept_version_id": 10961,
        "concept_name": "Myocardial infarction (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I21",
            "description": "Acute myocardial infarction",
            "attributes": null
          },
          {
            "code": "I22",
            "description": "Subsequent myocardial infarction",
            "attributes": null
          },
          {
            "code": "I252",
            "description": "Old myocardial infarction",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3627,
        "concept_version_id": 10962,
        "concept_name": "Congestive heart failure (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I099",
            "description": "Rheumatic heart disease, unspecified",
            "attributes": null
          },
          {
            "code": "I110",
            "description": "Hypertensive heart disease with (congestive) heart failure",
            "attributes": null
          },
          {
            "code": "I130",
            "description": "Hypertensive heart and renal disease with (congestive) heart failure",
            "attributes": null
          },
          {
            "code": "I132",
            "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure",
            "attributes": null
          },
          {
            "code": "I255",
            "description": "Ischaemic cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I420",
            "description": "Dilated cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I425",
            "description": "Other restrictive cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I426",
            "description": "Alcoholic cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I427",
            "description": "Cardiomyopathy due to drugs and other external agents",
            "attributes": null
          },
          {
            "code": "I428",
            "description": "Other cardiomyopathies",
            "attributes": null
          },
          {
            "code": "I429",
            "description": "Cardiomyopathy, unspecified",
            "attributes": null
          },
          {
            "code": "I43",
            "description": "Cardiomyopathy in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I50",
            "description": "Heart failure",
            "attributes": null
          },
          {
            "code": "P290",
            "description": "Neonatal cardiac failure",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3628,
        "concept_version_id": 10963,
        "concept_name": "Peripheral vascular disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I70",
            "description": "Atherosclerosis",
            "attributes": null
          },
          {
            "code": "I71",
            "description": "Aortic aneurysm and dissection",
            "attributes": null
          },
          {
            "code": "I731",
            "description": "Thromboangiitis obliterans [Buerger]",
            "attributes": null
          },
          {
            "code": "I738",
            "description": "Other specified peripheral vascular diseases",
            "attributes": null
          },
          {
            "code": "I739",
            "description": "Peripheral vascular disease, unspecified",
            "attributes": null
          },
          {
            "code": "I771",
            "description": "Stricture of artery",
            "attributes": null
          },
          {
            "code": "I790",
            "description": "Aneurysm of aorta in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I792",
            "description": "Peripheral angiopathy in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "K551",
            "description": "Chronic vascular disorders of intestine",
            "attributes": null
          },
          {
            "code": "K558",
            "description": "Other vascular disorders of intestine",
            "attributes": null
          },
          {
            "code": "K559",
            "description": "Vascular disorder of intestine, unspecified",
            "attributes": null
          },
          {
            "code": "Z958",
            "description": "Presence of other cardiac and vascular implants and grafts",
            "attributes": null
          },
          {
            "code": "Z959",
            "description": "Presence of cardiac and vascular implant and graft, unspecified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3629,
        "concept_version_id": 10964,
        "concept_name": "Cerebrovascular disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "G45",
            "description": "Transient cerebral ischaemic attacks and related syndromes",
            "attributes": null
          },
          {
            "code": "G46",
            "description": "Vascular syndromes of brain in cerebrovascular diseases",
            "attributes": null
          },
          {
            "code": "H340",
            "description": "Transient retinal artery occlusion",
            "attributes": null
          },
          {
            "code": "I60",
            "description": "Subarachnoid haemorrhage",
            "attributes": null
          },
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": null
          },
          {
            "code": "I62",
            "description": "Other nontraumatic intracranial haemorrhage",
            "attributes": null
          },
          {
            "code": "I63",
            "description": "Cerebral infarction",
            "attributes": null
          },
          {
            "code": "I64",
            "description": "Stroke, not specified as haemorrhage or infarction",
            "attributes": null
          },
          {
            "code": "I65",
            "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction",
            "attributes": null
          },
          {
            "code": "I66",
            "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction",
            "attributes": null
          },
          {
            "code": "I67",
            "description": "Other cerebrovascular diseases",
            "attributes": null
          },
          {
            "code": "I68",
            "description": "Cerebrovascular disorders in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I69",
            "description": "Sequelae of cerebrovascular disease",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3630,
        "concept_version_id": 10965,
        "concept_name": "Dementia (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "F00",
            "description": "Dementia in Alzheimer disease",
            "attributes": null
          },
          {
            "code": "F01",
            "description": "Vascular dementia",
            "attributes": null
          },
          {
            "code": "F02",
            "description": "Dementia in other diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "F03",
            "description": "Unspecified dementia",
            "attributes": null
          },
          {
            "code": "F051",
            "description": "Delirium superimposed on dementia",
            "attributes": null
          },
          {
            "code": "G30",
            "description": "Alzheimer disease",
            "attributes": null
          },
          {
            "code": "G311",
            "description": "Senile degeneration of brain, not elsewhere classified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3631,
        "concept_version_id": 10966,
        "concept_name": "Chronic pulmonary disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I278",
            "description": "Other specified pulmonary heart diseases",
            "attributes": null
          },
          {
            "code": "I279",
            "description": "Pulmonary heart disease, unspecified",
            "attributes": null
          },
          {
            "code": "J40",
            "description": "Bronchitis, not specified as acute or chronic",
            "attributes": null
          },
          {
            "code": "J41",
            "description": "Simple and mucopurulent chronic bronchitis",
            "attributes": null
          },
          {
            "code": "J42",
            "description": "Unspecified chronic bronchitis",
            "attributes": null
          },
          {
            "code": "J43",
            "description": "Emphysema",
            "attributes": null
          },
          {
            "code": "J44",
            "description": "Other chronic obstructive pulmonary disease",
            "attributes": null
          },
          {
            "code": "J45",
            "description": "Asthma",
            "attributes": null
          },
          {
            "code": "J46",
            "description": "Status asthmaticus",
            "attributes": null
          },
          {
            "code": "J47",
            "description": "Bronchiectasis",
            "attributes": null
          },
          {
            "code": "J60",
            "description": "Coalworker pneumoconiosis",
            "attributes": null
          },
          {
            "code": "J61",
            "description": "Pneumoconiosis due to asbestos and other mineral fibres",
            "attributes": null
          },
          {
            "code": "J62",
            "description": "Pneumoconiosis due to dust containing silica",
            "attributes": null
          },
          {
            "code": "J63",
            "description": "Pneumoconiosis due to other inorganic dusts",
            "attributes": null
          },
          {
            "code": "J64",
            "description": "Unspecified pneumoconiosis",
            "attributes": null
          },
          {
            "code": "J65",
            "description": "Pneumoconiosis associated with tuberculosis",
            "attributes": null
          },
          {
            "code": "J66",
            "description": "Airway disease due to specific organic dust",
            "attributes": null
          },
          {
            "code": "J67",
            "description": "Hypersensitivity pneumonitis due to organic dust",
            "attributes": null
          },
          {
            "code": "J684",
            "description": "Chronic respiratory conditions due to chemicals, gases, fumes and vapours",
            "attributes": null
          },
          {
            "code": "J701",
            "description": "Chronic and other pulmonary manifestations due to radiation",
            "attributes": null
          },
          {
            "code": "J703",
            "description": "Chronic drug-induced interstitial lung disorders",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3632,
        "concept_version_id": 10967,
        "concept_name": "Rheumatologic disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "M05",
            "description": "Seropositive rheumatoid arthritis",
            "attributes": null
          },
          {
            "code": "M06",
            "description": "Other rheumatoid arthritis",
            "attributes": null
          },
          {
            "code": "M315",
            "description": "Giant cell arteritis with polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "M32",
            "description": "Systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "M33",
            "description": "Dermatopolymyositis",
            "attributes": null
          },
          {
            "code": "M34",
            "description": "Systemic sclerosis",
            "attributes": null
          },
          {
            "code": "M351",
            "description": "Other overlap syndromes",
            "attributes": null
          },
          {
            "code": "M353",
            "description": "Polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "M360",
            "description": "Dermato(poly)myositis in neoplastic disease",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3633,
        "concept_version_id": 10968,
        "concept_name": "Peptic ulcer disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "K25",
            "description": "Gastric ulcer",
            "attributes": null
          },
          {
            "code": "K26",
            "description": "Duodenal ulcer",
            "attributes": null
          },
          {
            "code": "K27",
            "description": "Peptic ulcer, site unspecified",
            "attributes": null
          },
          {
            "code": "K28",
            "description": "Gastrojejunal ulcer",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3634,
        "concept_version_id": 10969,
        "concept_name": "Hemiplegia or paraplegia (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "G041",
            "description": "Tropical spastic paraplegia",
            "attributes": null
          },
          {
            "code": "G114",
            "description": "Hereditary spastic paraplegia",
            "attributes": null
          },
          {
            "code": "G801",
            "description": "Spastic diplegic cerebral palsy",
            "attributes": null
          },
          {
            "code": "G802",
            "description": "Spastic hemiplegic cerebral palsy",
            "attributes": null
          },
          {
            "code": "G81",
            "description": "Hemiplegia",
            "attributes": null
          },
          {
            "code": "G82",
            "description": "Paraplegia and tetraplegia",
            "attributes": null
          },
          {
            "code": "G830",
            "description": "Diplegia of upper limbs",
            "attributes": null
          },
          {
            "code": "G831",
            "description": "Monoplegia of lower limb",
            "attributes": null
          },
          {
            "code": "G832",
            "description": "Monoplegia of upper limb",
            "attributes": null
          },
          {
            "code": "G833",
            "description": "Monoplegia, unspecified",
            "attributes": null
          },
          {
            "code": "G834",
            "description": "Cauda equina syndrome",
            "attributes": null
          },
          {
            "code": "G839",
            "description": "Paralytic syndrome, unspecified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3635,
        "concept_version_id": 10970,
        "concept_name": "Diabetes without complications (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "E100",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E101",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E106",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E108",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E109",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E110",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E111",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E116",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E118",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E119",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E120",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E121",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E126",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E128",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E129",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E130",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E131",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E136",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E138",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E139",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E140",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E141",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E146",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E148",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E149",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3636,
        "concept_version_id": 10971,
        "concept_name": "Diabetes with chronic complications (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "E102",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E103",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E104",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E105",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E107",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E112",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E113",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E114",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E115",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E117",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E122",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E123",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E124",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E125",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E127",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E132",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E133",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E134",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E135",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E137",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E142",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E143",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E144",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E145",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E147",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3637,
        "concept_version_id": 10972,
        "concept_name": "Mild liver disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "B18",
            "description": "Chronic viral hepatitis",
            "attributes": null
          },
          {
            "code": "K700",
            "description": "Alcoholic fatty liver",
            "attributes": null
          },
          {
            "code": "K701",
            "description": "Alcoholic hepatitis",
            "attributes": null
          },
          {
            "code": "K702",
            "description": "Alcoholic fibrosis and sclerosis of liver",
            "attributes": null
          },
          {
            "code": "K703",
            "description": "Alcoholic cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K709",
            "description": "Alcoholic liver disease, unspecified",
            "attributes": null
          },
          {
            "code": "K713",
            "description": "Toxic liver disease with chronic persistent hepatitis",
            "attributes": null
          },
          {
            "code": "K714",
            "description": "Toxic liver disease with chronic lobular hepatitis",
            "attributes": null
          },
          {
            "code": "K715",
            "description": "Toxic liver disease with chronic active hepatitis",
            "attributes": null
          },
          {
            "code": "K717",
            "description": "Toxic liver disease with fibrosis and cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K73",
            "description": "Chronic hepatitis, not elsewhere classified",
            "attributes": null
          },
          {
            "code": "K74",
            "description": "Fibrosis and cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K760",
            "description": "Fatty (change of) liver, not elsewhere classified",
            "attributes": null
          },
          {
            "code": "K762",
            "description": "Central haemorrhagic necrosis of liver",
            "attributes": null
          },
          {
            "code": "K763",
            "description": "Infarction of liver",
            "attributes": null
          },
          {
            "code": "K764",
            "description": "Peliosis hepatis",
            "attributes": null
          },
          {
            "code": "K768",
            "description": "Other specified diseases of liver",
            "attributes": null
          },
          {
            "code": "K769",
            "description": "Liver disease, unspecified",
            "attributes": null
          },
          {
            "code": "Z944",
            "description": "Liver transplant status",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3638,
        "concept_version_id": 10973,
        "concept_name": "Moderate or severe liver disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I850",
            "description": "Oesophageal varices with bleeding",
            "attributes": null
          },
          {
            "code": "I859",
            "description": "Oesophageal varices without bleeding",
            "attributes": null
          },
          {
            "code": "I864",
            "description": "Gastric varices",
            "attributes": null
          },
          {
            "code": "I982",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "K704",
            "description": "Alcoholic hepatic failure",
            "attributes": null
          },
          {
            "code": "K711",
            "description": "Toxic liver disease with hepatic necrosis",
            "attributes": null
          },
          {
            "code": "K721",
            "description": "Chronic hepatic failure",
            "attributes": null
          },
          {
            "code": "K729",
            "description": "Hepatic failure, unspecified",
            "attributes": null
          },
          {
            "code": "K765",
            "description": "Hepatic veno-occlusive disease",
            "attributes": null
          },
          {
            "code": "K766",
            "description": "Portal hypertension",
            "attributes": null
          },
          {
            "code": "K767",
            "description": "Hepatorenal syndrome",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3639,
        "concept_version_id": 10974,
        "concept_name": "Renal disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I120",
            "description": "Hypertensive renal disease with renal failure",
            "attributes": null
          },
          {
            "code": "I131",
            "description": "Hypertensive heart and renal disease with renal failure",
            "attributes": null
          },
          {
            "code": "N032",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N033",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N034",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N035",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N036",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N037",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N052",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N053",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N054",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N055",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N056",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N057",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N18",
            "description": "Chronic kidney disease",
            "attributes": null
          },
          {
            "code": "N19",
            "description": "Unspecified kidney failure",
            "attributes": null
          },
          {
            "code": "N250",
            "description": "Renal osteodystrophy",
            "attributes": null
          },
          {
            "code": "Z490",
            "description": "Preparatory care for dialysis",
            "attributes": null
          },
          {
            "code": "Z491",
            "description": "Extracorporeal dialysis",
            "attributes": null
          },
          {
            "code": "Z492",
            "description": "Other dialysis",
            "attributes": null
          },
          {
            "code": "Z940",
            "description": "Kidney transplant status",
            "attributes": null
          },
          {
            "code": "Z992",
            "description": "Dependence on renal dialysis",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3640,
        "concept_version_id": 10975,
        "concept_name": "Malignancy (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "C00",
            "description": "Malignant neoplasm of lip",
            "attributes": null
          },
          {
            "code": "C01",
            "description": "Malignant neoplasm of base of tongue",
            "attributes": null
          },
          {
            "code": "C02",
            "description": "Malignant neoplasm of other and unspecified parts of tongue",
            "attributes": null
          },
          {
            "code": "C03",
            "description": "Malignant neoplasm of gum",
            "attributes": null
          },
          {
            "code": "C04",
            "description": "Malignant neoplasm of floor of mouth",
            "attributes": null
          },
          {
            "code": "C05",
            "description": "Malignant neoplasm of palate",
            "attributes": null
          },
          {
            "code": "C06",
            "description": "Malignant neoplasm of other and unspecified parts of mouth",
            "attributes": null
          },
          {
            "code": "C07",
            "description": "Malignant neoplasm of parotid gland",
            "attributes": null
          },
          {
            "code": "C08",
            "description": "Malignant neoplasm of other and unspecified major salivary glands",
            "attributes": null
          },
          {
            "code": "C09",
            "description": "Malignant neoplasm of tonsil",
            "attributes": null
          },
          {
            "code": "C10",
            "description": "Malignant neoplasm of oropharynx",
            "attributes": null
          },
          {
            "code": "C11",
            "description": "Malignant neoplasm of nasopharynx",
            "attributes": null
          },
          {
            "code": "C12",
            "description": "Malignant neoplasm of piriform sinus",
            "attributes": null
          },
          {
            "code": "C13",
            "description": "Malignant neoplasm of hypopharynx",
            "attributes": null
          },
          {
            "code": "C14",
            "description": "Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx",
            "attributes": null
          },
          {
            "code": "C15",
            "description": "Malignant neoplasm of oesophagus",
            "attributes": null
          },
          {
            "code": "C16",
            "description": "Malignant neoplasm of stomach",
            "attributes": null
          },
          {
            "code": "C17",
            "description": "Malignant neoplasm of small intestine",
            "attributes": null
          },
          {
            "code": "C18",
            "description": "Malignant neoplasm of colon",
            "attributes": null
          },
          {
            "code": "C19",
            "description": "Malignant neoplasm of rectosigmoid junction",
            "attributes": null
          },
          {
            "code": "C20",
            "description": "Malignant neoplasm of rectum",
            "attributes": null
          },
          {
            "code": "C21",
            "description": "Malignant neoplasm of anus and anal canal",
            "attributes": null
          },
          {
            "code": "C22",
            "description": "Malignant neoplasm of liver and intrahepatic bile ducts",
            "attributes": null
          },
          {
            "code": "C23",
            "description": "Malignant neoplasm of gallbladder",
            "attributes": null
          },
          {
            "code": "C24",
            "description": "Malignant neoplasm of other and unspecified parts of biliary tract",
            "attributes": null
          },
          {
            "code": "C25",
            "description": "Malignant neoplasm of pancreas",
            "attributes": null
          },
          {
            "code": "C26",
            "description": "Malignant neoplasm of other and ill-defined digestive organs",
            "attributes": null
          },
          {
            "code": "C30",
            "description": "Malignant neoplasm of nasal cavity and middle ear",
            "attributes": null
          },
          {
            "code": "C31",
            "description": "Malignant neoplasm of accessory sinuses",
            "attributes": null
          },
          {
            "code": "C32",
            "description": "Malignant neoplasm of larynx",
            "attributes": null
          },
          {
            "code": "C33",
            "description": "Malignant neoplasm of trachea",
            "attributes": null
          },
          {
            "code": "C34",
            "description": "Malignant neoplasm of bronchus and lung",
            "attributes": null
          },
          {
            "code": "C37",
            "description": "Malignant neoplasm of thymus",
            "attributes": null
          },
          {
            "code": "C38",
            "description": "Malignant neoplasm of heart, mediastinum and pleura",
            "attributes": null
          },
          {
            "code": "C39",
            "description": "Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs",
            "attributes": null
          },
          {
            "code": "C40",
            "description": "Malignant neoplasm of bone and articular cartilage of limbs",
            "attributes": null
          },
          {
            "code": "C41",
            "description": "Malignant neoplasm of bone and articular cartilage of other and unspecified sites",
            "attributes": null
          },
          {
            "code": "C43",
            "description": "Malignant melanoma of skin",
            "attributes": null
          },
          {
            "code": "C45",
            "description": "Mesothelioma",
            "attributes": null
          },
          {
            "code": "C46",
            "description": "Kaposi sarcoma",
            "attributes": null
          },
          {
            "code": "C47",
            "description": "Malignant neoplasm of peripheral nerves and autonomic nervous system",
            "attributes": null
          },
          {
            "code": "C48",
            "description": "Malignant neoplasm of retroperitoneum and peritoneum",
            "attributes": null
          },
          {
            "code": "C49",
            "description": "Malignant neoplasm of other connective and soft tissue",
            "attributes": null
          },
          {
            "code": "C50",
            "description": "Malignant neoplasm of breast",
            "attributes": null
          },
          {
            "code": "C51",
            "description": "Malignant neoplasm of vulva",
            "attributes": null
          },
          {
            "code": "C52",
            "description": "Malignant neoplasm of vagina",
            "attributes": null
          },
          {
            "code": "C53",
            "description": "Malignant neoplasm of cervix uteri",
            "attributes": null
          },
          {
            "code": "C54",
            "description": "Malignant neoplasm of corpus uteri",
            "attributes": null
          },
          {
            "code": "C55",
            "description": "Malignant neoplasm of uterus, part unspecified",
            "attributes": null
          },
          {
            "code": "C56",
            "description": "Malignant neoplasm of ovary",
            "attributes": null
          },
          {
            "code": "C57",
            "description": "Malignant neoplasm of other and unspecified female genital organs",
            "attributes": null
          },
          {
            "code": "C58",
            "description": "Malignant neoplasm of placenta",
            "attributes": null
          },
          {
            "code": "C60",
            "description": "Malignant neoplasm of penis",
            "attributes": null
          },
          {
            "code": "C61",
            "description": "Malignant neoplasm of prostate",
            "attributes": null
          },
          {
            "code": "C62",
            "description": "Malignant neoplasm of testis",
            "attributes": null
          },
          {
            "code": "C63",
            "description": "Malignant neoplasm of other and unspecified male genital organs",
            "attributes": null
          },
          {
            "code": "C64",
            "description": "Malignant neoplasm of kidney, except renal pelvis",
            "attributes": null
          },
          {
            "code": "C65",
            "description": "Malignant neoplasm of renal pelvis",
            "attributes": null
          },
          {
            "code": "C66",
            "description": "Malignant neoplasm of ureter",
            "attributes": null
          },
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": null
          },
          {
            "code": "C68",
            "description": "Malignant neoplasm of other and unspecified urinary organs",
            "attributes": null
          },
          {
            "code": "C69",
            "description": "Malignant neoplasm of eye and adnexa",
            "attributes": null
          },
          {
            "code": "C70",
            "description": "Malignant neoplasm of meninges",
            "attributes": null
          },
          {
            "code": "C71",
            "description": "Malignant neoplasm of brain",
            "attributes": null
          },
          {
            "code": "C72",
            "description": "Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system",
            "attributes": null
          },
          {
            "code": "C73",
            "description": "Malignant neoplasm of thyroid gland",
            "attributes": null
          },
          {
            "code": "C74",
            "description": "Malignant neoplasm of adrenal gland",
            "attributes": null
          },
          {
            "code": "C75",
            "description": "Malignant neoplasm of other endocrine glands and related structures",
            "attributes": null
          },
          {
            "code": "C76",
            "description": "Malignant neoplasm of other and ill-defined sites",
            "attributes": null
          },
          {
            "code": "C81",
            "description": "Hodgkin lymphoma",
            "attributes": null
          },
          {
            "code": "C82",
            "description": "Follicular lymphoma",
            "attributes": null
          },
          {
            "code": "C83",
            "description": "Non-follicular lymphoma",
            "attributes": null
          },
          {
            "code": "C84",
            "description": "Mature T/NK-cell lymphomas",
            "attributes": null
          },
          {
            "code": "C85",
            "description": "Other and unspecified types of non-Hodgkin lymphoma",
            "attributes": null
          },
          {
            "code": "C88",
            "description": "Malignant immunoproliferative diseases",
            "attributes": null
          },
          {
            "code": "C90",
            "description": "Multiple myeloma and malignant plasma cell neoplasms",
            "attributes": null
          },
          {
            "code": "C91",
            "description": "Lymphoid leukaemia",
            "attributes": null
          },
          {
            "code": "C92",
            "description": "Myeloid leukaemia",
            "attributes": null
          },
          {
            "code": "C93",
            "description": "Monocytic leukaemia",
            "attributes": null
          },
          {
            "code": "C94",
            "description": "Other leukaemias of specified cell type",
            "attributes": null
          },
          {
            "code": "C95",
            "description": "Leukaemia of unspecified cell type",
            "attributes": null
          },
          {
            "code": "C96",
            "description": "Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue",
            "attributes": null
          },
          {
            "code": "C97",
            "description": "Malignant neoplasms of independent (primary) multiple sites",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3641,
        "concept_version_id": 10976,
        "concept_name": "Metastatic solid tumor (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": null
          },
          {
            "code": "C78",
            "description": "Secondary malignant neoplasm of respiratory and digestive organs",
            "attributes": null
          },
          {
            "code": "C79",
            "description": "Secondary malignant neoplasm of other and unspecified sites",
            "attributes": null
          },
          {
            "code": "C80",
            "description": "Malignant neoplasm without specification of site",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3642,
        "concept_version_id": 10977,
        "concept_name": "HIV or AIDS (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1657",
        "phenotype_version_id": 3432,
        "phenotype_name": "Charlson comorbidity index (Quan 2011)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "B20",
            "description": "Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases",
            "attributes": null
          },
          {
            "code": "B21",
            "description": "Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms",
            "attributes": null
          },
          {
            "code": "B22",
            "description": "Human immunodeficiency virus [HIV] disease resulting in other specified diseases",
            "attributes": null
          },
          {
            "code": "B24",
            "description": "Unspecified human immunodeficiency virus [HIV] disease",
            "attributes": null
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/fag5-sb54",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "farrellj",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 3432,
        "version_name": "Charlson comorbidity index (Quan 2011)",
        "version_date": "2024-06-25T21:01:22.865428Z",
        "is_published": true,
        "is_latest": true
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  }
]