[
  {
    "phenotype_id": "PH1658",
    "phenotype_version_id": 3431,
    "name": "Charlson comorbidity index (Charlson 1987)",
    "definition": "The Charlson comorbidity index (CCI), includes comorbidities used to predict mortality risk and healthcare utilisation. The index is composed of 12 comorbidities (17 when stratified by severity) showed good-to-excellent discrimination in predicting in-hospital mortality in data from 6 countries and may be appropriate for use with more recent administrative data.\n\n[ICD-10 codes](https://github.com/ellessenne/comorbidity/blob/master/data-raw/make-mapping.R) and condition [weightings](https://github.com/ellessenne/comorbidity/blob/master/data-raw/make-weights.R) were obtained from the source code of the \"comorbidity\" R package.\n\n**References**\n\n- Charlson, M.E. et al. (1987) ‘A new method of classifying prognostic comorbidity in Longitudinal Studies: Development and validation’, Journal of Chronic Diseases, 40(5), pp. 373–383. doi:10.1016/0021-9681(87)90171-8.\n\n- Gasparini, (2018). comorbidity: An R package for computing comorbidity scores. Journal of Open Source Software, 3(23), 648, https://doi.org/10.21105/joss.00648",
    "implementation": "**CCI Scoring System**\n\nThe conditions have the following weightings:\n\n1. Myocardial infarction: 1\n\n2. Congestive heart failure: 1\n\n3. Peripheral vascular disease: 1\n\n4. Cerebrovascular disease: 1\n\n5. Dementia: 1\n\n6. Chronic pulmonary disease: 1\n\n7. Rheumatologic disease: 1\n\n8. Peptic ulcer disease: 1\n\n9. Hemiplegia/ paraplegia: 2\n\n10. Diabetes without complications: 1\n\n11. Diabetes with chronic complications: 2\n\n12. Mild liver disease: 1\n\n13. Moderate/severe liver disease: 3\n\n14. Renal disease: 2\n\n15. Malignancy (tumor, leukemia, lymphoma): 2\n\n16. Metastatic solid tumor: 6\n\n17. HIV/AIDS: 6\n\n**Hierarchy Categories**\n\nWithin each hierarchy category, the milder condition should not contribute to the CCI score if a more severe condition is present, even though codes for both may appear for an individual patient.\n\n1. \"Diabetes with chronic complications\" (Condition 11) trumps \"Diabetes without complications\" (Condition 10)\n\n2. \"Moderate/severe liver disease\" (Condition 13) trumps \"Mild liver disease\" (Condition 12)\n\n3. \"Metastatic solid tumor\" (Condition 16) trumps \"Malignancy\" (Condition 15)",
    "publications": [
      {
        "doi": "10.1016/0021-9681(87)90171-8",
        "details": "Charlson, M.E. et al. (1987) ‘A new method of classifying prognostic comorbidity in Longitudinal Studies: Development and validation’, Journal of Chronic Diseases, 40(5), pp. 373–383. doi:10.1016/0021-9681(87)90171-8. "
      },
      {
        "doi": "10.21105/joss.00648",
        "details": "Gasparini, (2018). comorbidity: An R package for computing comorbidity scores. Journal of Open Source Software, 3(23), 648, https://doi.org/10.21105/joss.00648"
      }
    ],
    "validation": "",
    "citation_requirements": "Charlson, M.E. et al. (1987) ‘A new method of classifying prognostic comorbidity in Longitudinal Studies: Development and validation’, Journal of Chronic Diseases, 40(5), pp. 373–383. doi:10.1016/0021-9681(87)90171-8.",
    "created": "2024-06-25T20:38:24.148033Z",
    "author": "Mary E. Charlson, Peter Pompei, Kathy L. Ales, C. Ronald MacKenzie",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      }
    ],
    "tags": [
      {
        "name": "Comorbidity Index",
        "value": 29
      }
    ],
    "organisation": {
      "id": 13,
      "slug": "bhf-data-science-centre",
      "name": "BHF Data Science Centre"
    },
    "world_access": 2,
    "updated": "2024-06-25T21:00:11.706132Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": null,
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "Hospital Episode Statistics Admitted Patient Care",
        "value": 2,
        "uid": "6599230a-df54-4615-937c-d724d239491f",
        "url": "https://healthdatagateway.org/en/dataset/875",
        "datasource_id": 875
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": null,
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 3637,
        "concept_version_id": 10972,
        "concept_name": "Mild liver disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "B18",
            "description": "Chronic viral hepatitis",
            "attributes": null
          },
          {
            "code": "K700",
            "description": "Alcoholic fatty liver",
            "attributes": null
          },
          {
            "code": "K701",
            "description": "Alcoholic hepatitis",
            "attributes": null
          },
          {
            "code": "K702",
            "description": "Alcoholic fibrosis and sclerosis of liver",
            "attributes": null
          },
          {
            "code": "K703",
            "description": "Alcoholic cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K709",
            "description": "Alcoholic liver disease, unspecified",
            "attributes": null
          },
          {
            "code": "K713",
            "description": "Toxic liver disease with chronic persistent hepatitis",
            "attributes": null
          },
          {
            "code": "K714",
            "description": "Toxic liver disease with chronic lobular hepatitis",
            "attributes": null
          },
          {
            "code": "K715",
            "description": "Toxic liver disease with chronic active hepatitis",
            "attributes": null
          },
          {
            "code": "K717",
            "description": "Toxic liver disease with fibrosis and cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K73",
            "description": "Chronic hepatitis, not elsewhere classified",
            "attributes": null
          },
          {
            "code": "K74",
            "description": "Fibrosis and cirrhosis of liver",
            "attributes": null
          },
          {
            "code": "K760",
            "description": "Fatty (change of) liver, not elsewhere classified",
            "attributes": null
          },
          {
            "code": "K762",
            "description": "Central haemorrhagic necrosis of liver",
            "attributes": null
          },
          {
            "code": "K763",
            "description": "Infarction of liver",
            "attributes": null
          },
          {
            "code": "K764",
            "description": "Peliosis hepatis",
            "attributes": null
          },
          {
            "code": "K768",
            "description": "Other specified diseases of liver",
            "attributes": null
          },
          {
            "code": "K769",
            "description": "Liver disease, unspecified",
            "attributes": null
          },
          {
            "code": "Z944",
            "description": "Liver transplant status",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3626,
        "concept_version_id": 10961,
        "concept_name": "Myocardial infarction (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I21",
            "description": "Acute myocardial infarction",
            "attributes": null
          },
          {
            "code": "I22",
            "description": "Subsequent myocardial infarction",
            "attributes": null
          },
          {
            "code": "I252",
            "description": "Old myocardial infarction",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3627,
        "concept_version_id": 10962,
        "concept_name": "Congestive heart failure (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I099",
            "description": "Rheumatic heart disease, unspecified",
            "attributes": null
          },
          {
            "code": "I110",
            "description": "Hypertensive heart disease with (congestive) heart failure",
            "attributes": null
          },
          {
            "code": "I130",
            "description": "Hypertensive heart and renal disease with (congestive) heart failure",
            "attributes": null
          },
          {
            "code": "I132",
            "description": "Hypertensive heart and renal disease with both (congestive) heart failure and renal failure",
            "attributes": null
          },
          {
            "code": "I255",
            "description": "Ischaemic cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I420",
            "description": "Dilated cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I425",
            "description": "Other restrictive cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I426",
            "description": "Alcoholic cardiomyopathy",
            "attributes": null
          },
          {
            "code": "I427",
            "description": "Cardiomyopathy due to drugs and other external agents",
            "attributes": null
          },
          {
            "code": "I428",
            "description": "Other cardiomyopathies",
            "attributes": null
          },
          {
            "code": "I429",
            "description": "Cardiomyopathy, unspecified",
            "attributes": null
          },
          {
            "code": "I43",
            "description": "Cardiomyopathy in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I50",
            "description": "Heart failure",
            "attributes": null
          },
          {
            "code": "P290",
            "description": "Neonatal cardiac failure",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3628,
        "concept_version_id": 10963,
        "concept_name": "Peripheral vascular disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I70",
            "description": "Atherosclerosis",
            "attributes": null
          },
          {
            "code": "I71",
            "description": "Aortic aneurysm and dissection",
            "attributes": null
          },
          {
            "code": "I731",
            "description": "Thromboangiitis obliterans [Buerger]",
            "attributes": null
          },
          {
            "code": "I738",
            "description": "Other specified peripheral vascular diseases",
            "attributes": null
          },
          {
            "code": "I739",
            "description": "Peripheral vascular disease, unspecified",
            "attributes": null
          },
          {
            "code": "I771",
            "description": "Stricture of artery",
            "attributes": null
          },
          {
            "code": "I790",
            "description": "Aneurysm of aorta in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I792",
            "description": "Peripheral angiopathy in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "K551",
            "description": "Chronic vascular disorders of intestine",
            "attributes": null
          },
          {
            "code": "K558",
            "description": "Other vascular disorders of intestine",
            "attributes": null
          },
          {
            "code": "K559",
            "description": "Vascular disorder of intestine, unspecified",
            "attributes": null
          },
          {
            "code": "Z958",
            "description": "Presence of other cardiac and vascular implants and grafts",
            "attributes": null
          },
          {
            "code": "Z959",
            "description": "Presence of cardiac and vascular implant and graft, unspecified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3629,
        "concept_version_id": 10964,
        "concept_name": "Cerebrovascular disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "G45",
            "description": "Transient cerebral ischaemic attacks and related syndromes",
            "attributes": null
          },
          {
            "code": "G46",
            "description": "Vascular syndromes of brain in cerebrovascular diseases",
            "attributes": null
          },
          {
            "code": "H340",
            "description": "Transient retinal artery occlusion",
            "attributes": null
          },
          {
            "code": "I60",
            "description": "Subarachnoid haemorrhage",
            "attributes": null
          },
          {
            "code": "I61",
            "description": "Intracerebral haemorrhage",
            "attributes": null
          },
          {
            "code": "I62",
            "description": "Other nontraumatic intracranial haemorrhage",
            "attributes": null
          },
          {
            "code": "I63",
            "description": "Cerebral infarction",
            "attributes": null
          },
          {
            "code": "I64",
            "description": "Stroke, not specified as haemorrhage or infarction",
            "attributes": null
          },
          {
            "code": "I65",
            "description": "Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction",
            "attributes": null
          },
          {
            "code": "I66",
            "description": "Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction",
            "attributes": null
          },
          {
            "code": "I67",
            "description": "Other cerebrovascular diseases",
            "attributes": null
          },
          {
            "code": "I68",
            "description": "Cerebrovascular disorders in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "I69",
            "description": "Sequelae of cerebrovascular disease",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3630,
        "concept_version_id": 10965,
        "concept_name": "Dementia (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "F00",
            "description": "Dementia in Alzheimer disease",
            "attributes": null
          },
          {
            "code": "F01",
            "description": "Vascular dementia",
            "attributes": null
          },
          {
            "code": "F02",
            "description": "Dementia in other diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "F03",
            "description": "Unspecified dementia",
            "attributes": null
          },
          {
            "code": "F051",
            "description": "Delirium superimposed on dementia",
            "attributes": null
          },
          {
            "code": "G30",
            "description": "Alzheimer disease",
            "attributes": null
          },
          {
            "code": "G311",
            "description": "Senile degeneration of brain, not elsewhere classified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3631,
        "concept_version_id": 10966,
        "concept_name": "Chronic pulmonary disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I278",
            "description": "Other specified pulmonary heart diseases",
            "attributes": null
          },
          {
            "code": "I279",
            "description": "Pulmonary heart disease, unspecified",
            "attributes": null
          },
          {
            "code": "J40",
            "description": "Bronchitis, not specified as acute or chronic",
            "attributes": null
          },
          {
            "code": "J41",
            "description": "Simple and mucopurulent chronic bronchitis",
            "attributes": null
          },
          {
            "code": "J42",
            "description": "Unspecified chronic bronchitis",
            "attributes": null
          },
          {
            "code": "J43",
            "description": "Emphysema",
            "attributes": null
          },
          {
            "code": "J44",
            "description": "Other chronic obstructive pulmonary disease",
            "attributes": null
          },
          {
            "code": "J45",
            "description": "Asthma",
            "attributes": null
          },
          {
            "code": "J46",
            "description": "Status asthmaticus",
            "attributes": null
          },
          {
            "code": "J47",
            "description": "Bronchiectasis",
            "attributes": null
          },
          {
            "code": "J60",
            "description": "Coalworker pneumoconiosis",
            "attributes": null
          },
          {
            "code": "J61",
            "description": "Pneumoconiosis due to asbestos and other mineral fibres",
            "attributes": null
          },
          {
            "code": "J62",
            "description": "Pneumoconiosis due to dust containing silica",
            "attributes": null
          },
          {
            "code": "J63",
            "description": "Pneumoconiosis due to other inorganic dusts",
            "attributes": null
          },
          {
            "code": "J64",
            "description": "Unspecified pneumoconiosis",
            "attributes": null
          },
          {
            "code": "J65",
            "description": "Pneumoconiosis associated with tuberculosis",
            "attributes": null
          },
          {
            "code": "J66",
            "description": "Airway disease due to specific organic dust",
            "attributes": null
          },
          {
            "code": "J67",
            "description": "Hypersensitivity pneumonitis due to organic dust",
            "attributes": null
          },
          {
            "code": "J684",
            "description": "Chronic respiratory conditions due to chemicals, gases, fumes and vapours",
            "attributes": null
          },
          {
            "code": "J701",
            "description": "Chronic and other pulmonary manifestations due to radiation",
            "attributes": null
          },
          {
            "code": "J703",
            "description": "Chronic drug-induced interstitial lung disorders",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3632,
        "concept_version_id": 10967,
        "concept_name": "Rheumatologic disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "M05",
            "description": "Seropositive rheumatoid arthritis",
            "attributes": null
          },
          {
            "code": "M06",
            "description": "Other rheumatoid arthritis",
            "attributes": null
          },
          {
            "code": "M315",
            "description": "Giant cell arteritis with polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "M32",
            "description": "Systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "M33",
            "description": "Dermatopolymyositis",
            "attributes": null
          },
          {
            "code": "M34",
            "description": "Systemic sclerosis",
            "attributes": null
          },
          {
            "code": "M351",
            "description": "Other overlap syndromes",
            "attributes": null
          },
          {
            "code": "M353",
            "description": "Polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "M360",
            "description": "Dermato(poly)myositis in neoplastic disease",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3633,
        "concept_version_id": 10968,
        "concept_name": "Peptic ulcer disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "K25",
            "description": "Gastric ulcer",
            "attributes": null
          },
          {
            "code": "K26",
            "description": "Duodenal ulcer",
            "attributes": null
          },
          {
            "code": "K27",
            "description": "Peptic ulcer, site unspecified",
            "attributes": null
          },
          {
            "code": "K28",
            "description": "Gastrojejunal ulcer",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3634,
        "concept_version_id": 10969,
        "concept_name": "Hemiplegia or paraplegia (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "G041",
            "description": "Tropical spastic paraplegia",
            "attributes": null
          },
          {
            "code": "G114",
            "description": "Hereditary spastic paraplegia",
            "attributes": null
          },
          {
            "code": "G801",
            "description": "Spastic diplegic cerebral palsy",
            "attributes": null
          },
          {
            "code": "G802",
            "description": "Spastic hemiplegic cerebral palsy",
            "attributes": null
          },
          {
            "code": "G81",
            "description": "Hemiplegia",
            "attributes": null
          },
          {
            "code": "G82",
            "description": "Paraplegia and tetraplegia",
            "attributes": null
          },
          {
            "code": "G830",
            "description": "Diplegia of upper limbs",
            "attributes": null
          },
          {
            "code": "G831",
            "description": "Monoplegia of lower limb",
            "attributes": null
          },
          {
            "code": "G832",
            "description": "Monoplegia of upper limb",
            "attributes": null
          },
          {
            "code": "G833",
            "description": "Monoplegia, unspecified",
            "attributes": null
          },
          {
            "code": "G834",
            "description": "Cauda equina syndrome",
            "attributes": null
          },
          {
            "code": "G839",
            "description": "Paralytic syndrome, unspecified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3635,
        "concept_version_id": 10970,
        "concept_name": "Diabetes without complications (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "E100",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E101",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E106",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E108",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E109",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E110",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E111",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E116",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E118",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E119",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E120",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E121",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E126",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E128",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E129",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E130",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E131",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E136",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E138",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E139",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E140",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E141",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E146",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E148",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E149",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3636,
        "concept_version_id": 10971,
        "concept_name": "Diabetes with chronic complications (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "E102",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E103",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E104",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E105",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E107",
            "description": "Type 1 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E112",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E113",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E114",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E115",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E117",
            "description": "Type 2 diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E122",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E123",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E124",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E125",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E127",
            "description": "Malnutrition-related diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E132",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E133",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E134",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E135",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E137",
            "description": "Other specified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E142",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E143",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E144",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E145",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          },
          {
            "code": "E147",
            "description": "Unspecified diabetes mellitus",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3638,
        "concept_version_id": 10973,
        "concept_name": "Moderate or severe liver disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I850",
            "description": "Oesophageal varices with bleeding",
            "attributes": null
          },
          {
            "code": "I859",
            "description": "Oesophageal varices without bleeding",
            "attributes": null
          },
          {
            "code": "I864",
            "description": "Gastric varices",
            "attributes": null
          },
          {
            "code": "I982",
            "description": "Oesophageal varices without bleeding in diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "K704",
            "description": "Alcoholic hepatic failure",
            "attributes": null
          },
          {
            "code": "K711",
            "description": "Toxic liver disease with hepatic necrosis",
            "attributes": null
          },
          {
            "code": "K721",
            "description": "Chronic hepatic failure",
            "attributes": null
          },
          {
            "code": "K729",
            "description": "Hepatic failure, unspecified",
            "attributes": null
          },
          {
            "code": "K765",
            "description": "Hepatic veno-occlusive disease",
            "attributes": null
          },
          {
            "code": "K766",
            "description": "Portal hypertension",
            "attributes": null
          },
          {
            "code": "K767",
            "description": "Hepatorenal syndrome",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3639,
        "concept_version_id": 10974,
        "concept_name": "Renal disease (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I120",
            "description": "Hypertensive renal disease with renal failure",
            "attributes": null
          },
          {
            "code": "I131",
            "description": "Hypertensive heart and renal disease with renal failure",
            "attributes": null
          },
          {
            "code": "N032",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N033",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N034",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N035",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N036",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N037",
            "description": "Chronic nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N052",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N053",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N054",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N055",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N056",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N057",
            "description": "Unspecified nephritic syndrome",
            "attributes": null
          },
          {
            "code": "N18",
            "description": "Chronic kidney disease",
            "attributes": null
          },
          {
            "code": "N19",
            "description": "Unspecified kidney failure",
            "attributes": null
          },
          {
            "code": "N250",
            "description": "Renal osteodystrophy",
            "attributes": null
          },
          {
            "code": "Z490",
            "description": "Preparatory care for dialysis",
            "attributes": null
          },
          {
            "code": "Z491",
            "description": "Extracorporeal dialysis",
            "attributes": null
          },
          {
            "code": "Z492",
            "description": "Other dialysis",
            "attributes": null
          },
          {
            "code": "Z940",
            "description": "Kidney transplant status",
            "attributes": null
          },
          {
            "code": "Z992",
            "description": "Dependence on renal dialysis",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3640,
        "concept_version_id": 10975,
        "concept_name": "Malignancy (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "C00",
            "description": "Malignant neoplasm of lip",
            "attributes": null
          },
          {
            "code": "C01",
            "description": "Malignant neoplasm of base of tongue",
            "attributes": null
          },
          {
            "code": "C02",
            "description": "Malignant neoplasm of other and unspecified parts of tongue",
            "attributes": null
          },
          {
            "code": "C03",
            "description": "Malignant neoplasm of gum",
            "attributes": null
          },
          {
            "code": "C04",
            "description": "Malignant neoplasm of floor of mouth",
            "attributes": null
          },
          {
            "code": "C05",
            "description": "Malignant neoplasm of palate",
            "attributes": null
          },
          {
            "code": "C06",
            "description": "Malignant neoplasm of other and unspecified parts of mouth",
            "attributes": null
          },
          {
            "code": "C07",
            "description": "Malignant neoplasm of parotid gland",
            "attributes": null
          },
          {
            "code": "C08",
            "description": "Malignant neoplasm of other and unspecified major salivary glands",
            "attributes": null
          },
          {
            "code": "C09",
            "description": "Malignant neoplasm of tonsil",
            "attributes": null
          },
          {
            "code": "C10",
            "description": "Malignant neoplasm of oropharynx",
            "attributes": null
          },
          {
            "code": "C11",
            "description": "Malignant neoplasm of nasopharynx",
            "attributes": null
          },
          {
            "code": "C12",
            "description": "Malignant neoplasm of piriform sinus",
            "attributes": null
          },
          {
            "code": "C13",
            "description": "Malignant neoplasm of hypopharynx",
            "attributes": null
          },
          {
            "code": "C14",
            "description": "Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx",
            "attributes": null
          },
          {
            "code": "C15",
            "description": "Malignant neoplasm of oesophagus",
            "attributes": null
          },
          {
            "code": "C16",
            "description": "Malignant neoplasm of stomach",
            "attributes": null
          },
          {
            "code": "C17",
            "description": "Malignant neoplasm of small intestine",
            "attributes": null
          },
          {
            "code": "C18",
            "description": "Malignant neoplasm of colon",
            "attributes": null
          },
          {
            "code": "C19",
            "description": "Malignant neoplasm of rectosigmoid junction",
            "attributes": null
          },
          {
            "code": "C20",
            "description": "Malignant neoplasm of rectum",
            "attributes": null
          },
          {
            "code": "C21",
            "description": "Malignant neoplasm of anus and anal canal",
            "attributes": null
          },
          {
            "code": "C22",
            "description": "Malignant neoplasm of liver and intrahepatic bile ducts",
            "attributes": null
          },
          {
            "code": "C23",
            "description": "Malignant neoplasm of gallbladder",
            "attributes": null
          },
          {
            "code": "C24",
            "description": "Malignant neoplasm of other and unspecified parts of biliary tract",
            "attributes": null
          },
          {
            "code": "C25",
            "description": "Malignant neoplasm of pancreas",
            "attributes": null
          },
          {
            "code": "C26",
            "description": "Malignant neoplasm of other and ill-defined digestive organs",
            "attributes": null
          },
          {
            "code": "C30",
            "description": "Malignant neoplasm of nasal cavity and middle ear",
            "attributes": null
          },
          {
            "code": "C31",
            "description": "Malignant neoplasm of accessory sinuses",
            "attributes": null
          },
          {
            "code": "C32",
            "description": "Malignant neoplasm of larynx",
            "attributes": null
          },
          {
            "code": "C33",
            "description": "Malignant neoplasm of trachea",
            "attributes": null
          },
          {
            "code": "C34",
            "description": "Malignant neoplasm of bronchus and lung",
            "attributes": null
          },
          {
            "code": "C37",
            "description": "Malignant neoplasm of thymus",
            "attributes": null
          },
          {
            "code": "C38",
            "description": "Malignant neoplasm of heart, mediastinum and pleura",
            "attributes": null
          },
          {
            "code": "C39",
            "description": "Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs",
            "attributes": null
          },
          {
            "code": "C40",
            "description": "Malignant neoplasm of bone and articular cartilage of limbs",
            "attributes": null
          },
          {
            "code": "C41",
            "description": "Malignant neoplasm of bone and articular cartilage of other and unspecified sites",
            "attributes": null
          },
          {
            "code": "C43",
            "description": "Malignant melanoma of skin",
            "attributes": null
          },
          {
            "code": "C45",
            "description": "Mesothelioma",
            "attributes": null
          },
          {
            "code": "C46",
            "description": "Kaposi sarcoma",
            "attributes": null
          },
          {
            "code": "C47",
            "description": "Malignant neoplasm of peripheral nerves and autonomic nervous system",
            "attributes": null
          },
          {
            "code": "C48",
            "description": "Malignant neoplasm of retroperitoneum and peritoneum",
            "attributes": null
          },
          {
            "code": "C49",
            "description": "Malignant neoplasm of other connective and soft tissue",
            "attributes": null
          },
          {
            "code": "C50",
            "description": "Malignant neoplasm of breast",
            "attributes": null
          },
          {
            "code": "C51",
            "description": "Malignant neoplasm of vulva",
            "attributes": null
          },
          {
            "code": "C52",
            "description": "Malignant neoplasm of vagina",
            "attributes": null
          },
          {
            "code": "C53",
            "description": "Malignant neoplasm of cervix uteri",
            "attributes": null
          },
          {
            "code": "C54",
            "description": "Malignant neoplasm of corpus uteri",
            "attributes": null
          },
          {
            "code": "C55",
            "description": "Malignant neoplasm of uterus, part unspecified",
            "attributes": null
          },
          {
            "code": "C56",
            "description": "Malignant neoplasm of ovary",
            "attributes": null
          },
          {
            "code": "C57",
            "description": "Malignant neoplasm of other and unspecified female genital organs",
            "attributes": null
          },
          {
            "code": "C58",
            "description": "Malignant neoplasm of placenta",
            "attributes": null
          },
          {
            "code": "C60",
            "description": "Malignant neoplasm of penis",
            "attributes": null
          },
          {
            "code": "C61",
            "description": "Malignant neoplasm of prostate",
            "attributes": null
          },
          {
            "code": "C62",
            "description": "Malignant neoplasm of testis",
            "attributes": null
          },
          {
            "code": "C63",
            "description": "Malignant neoplasm of other and unspecified male genital organs",
            "attributes": null
          },
          {
            "code": "C64",
            "description": "Malignant neoplasm of kidney, except renal pelvis",
            "attributes": null
          },
          {
            "code": "C65",
            "description": "Malignant neoplasm of renal pelvis",
            "attributes": null
          },
          {
            "code": "C66",
            "description": "Malignant neoplasm of ureter",
            "attributes": null
          },
          {
            "code": "C67",
            "description": "Malignant neoplasm of bladder",
            "attributes": null
          },
          {
            "code": "C68",
            "description": "Malignant neoplasm of other and unspecified urinary organs",
            "attributes": null
          },
          {
            "code": "C69",
            "description": "Malignant neoplasm of eye and adnexa",
            "attributes": null
          },
          {
            "code": "C70",
            "description": "Malignant neoplasm of meninges",
            "attributes": null
          },
          {
            "code": "C71",
            "description": "Malignant neoplasm of brain",
            "attributes": null
          },
          {
            "code": "C72",
            "description": "Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system",
            "attributes": null
          },
          {
            "code": "C73",
            "description": "Malignant neoplasm of thyroid gland",
            "attributes": null
          },
          {
            "code": "C74",
            "description": "Malignant neoplasm of adrenal gland",
            "attributes": null
          },
          {
            "code": "C75",
            "description": "Malignant neoplasm of other endocrine glands and related structures",
            "attributes": null
          },
          {
            "code": "C76",
            "description": "Malignant neoplasm of other and ill-defined sites",
            "attributes": null
          },
          {
            "code": "C81",
            "description": "Hodgkin lymphoma",
            "attributes": null
          },
          {
            "code": "C82",
            "description": "Follicular lymphoma",
            "attributes": null
          },
          {
            "code": "C83",
            "description": "Non-follicular lymphoma",
            "attributes": null
          },
          {
            "code": "C84",
            "description": "Mature T/NK-cell lymphomas",
            "attributes": null
          },
          {
            "code": "C85",
            "description": "Other and unspecified types of non-Hodgkin lymphoma",
            "attributes": null
          },
          {
            "code": "C88",
            "description": "Malignant immunoproliferative diseases",
            "attributes": null
          },
          {
            "code": "C90",
            "description": "Multiple myeloma and malignant plasma cell neoplasms",
            "attributes": null
          },
          {
            "code": "C91",
            "description": "Lymphoid leukaemia",
            "attributes": null
          },
          {
            "code": "C92",
            "description": "Myeloid leukaemia",
            "attributes": null
          },
          {
            "code": "C93",
            "description": "Monocytic leukaemia",
            "attributes": null
          },
          {
            "code": "C94",
            "description": "Other leukaemias of specified cell type",
            "attributes": null
          },
          {
            "code": "C95",
            "description": "Leukaemia of unspecified cell type",
            "attributes": null
          },
          {
            "code": "C96",
            "description": "Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue",
            "attributes": null
          },
          {
            "code": "C97",
            "description": "Malignant neoplasms of independent (primary) multiple sites",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3641,
        "concept_version_id": 10976,
        "concept_name": "Metastatic solid tumor (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
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            "code": "C77",
            "description": "Secondary and unspecified malignant neoplasm of lymph nodes",
            "attributes": null
          },
          {
            "code": "C78",
            "description": "Secondary malignant neoplasm of respiratory and digestive organs",
            "attributes": null
          },
          {
            "code": "C79",
            "description": "Secondary malignant neoplasm of other and unspecified sites",
            "attributes": null
          },
          {
            "code": "C80",
            "description": "Malignant neoplasm without specification of site",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 3642,
        "concept_version_id": 10977,
        "concept_name": "HIV or AIDS (Charlson comorbidity index)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1658",
        "phenotype_version_id": 3431,
        "phenotype_name": "Charlson comorbidity index (Charlson 1987)",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "B20",
            "description": "Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases",
            "attributes": null
          },
          {
            "code": "B21",
            "description": "Human immunodeficiency virus [HIV] disease resulting in malignant neoplasms",
            "attributes": null
          },
          {
            "code": "B22",
            "description": "Human immunodeficiency virus [HIV] disease resulting in other specified diseases",
            "attributes": null
          },
          {
            "code": "B24",
            "description": "Unspecified human immunodeficiency virus [HIV] disease",
            "attributes": null
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/ybt1-2257",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "farrellj",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 3431,
        "version_name": "Charlson comorbidity index (Charlson 1987)",
        "version_date": "2024-06-25T21:00:11.717113Z",
        "is_published": true,
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      }
    ]
  }
]