[
  {
    "phenotype_id": "PH1706",
    "phenotype_version_id": 3631,
    "name": "Chronic paediatric conditions: Immunological",
    "definition": "This code list is part of a set of harmonised code lists to identify chronic paediatric\nconditions across primary and secondary care datasets across the UK.\n\n- ICD-10 immunological conditions as per Hardelid 2014, mapped to SNOMED and Read v2 using CALIBER.\n- Includes e.g., immunodeficiencies, disorders of neutrophil function and genetic disorders of leucocyte function.\n\n### Methods\n\nChronic paediatric conditions were defined as health problems requiring medical follow-up\nfor more than 12 months in 50% or more of cases. Code lists were produced by mapping\nexisting ICD-10 codes for chronic paediatric conditions to SNOMED and Read v2 codes\nusing the CALIBER R package, with review by paediatric sub-specialists.\n\nAn established ICD-10 code list of chronic paediatric conditions (Hardelid 2014)\nwas used as the basis for the new lists.[1]  Chronic paediatric conditions were defined\nas any health problem requiring medical follow-up (hospital admission, outpatient\nfollow up or use of support services such as physiotherapy) for more than 12 months\nin 50% or more of cases.[1]  A Chronic Paediatric Conditions Committee of paediatric\nsub-specialists was established. The original ICD-10 list was screened by two paediatricians\nand acute conditions removed, with disagreements resolved by a third paediatrician.\nConditions which were likely acute and would not fulfil our chronic disease definition\nwere excluded, including skeletal injuries and self-harm. Drug-induced conditions\nwere excluded as chronicity was not known. Infections other than human immunodeficiency\nvirus (HIV), hepatitis B or C, or congenital infections (syphilis / toxoplasmosis\n/ rubella / herpes simplex virus / cytomegalovirus) were excluded. Chronic sequelae\nof infections were retained.\n\nPublished code lists were then identified for Read v2 and SNOMED codes for well-characterised\nconditions including asthma, diabetes, cystic fibrosis and cancer. The remaining\nICD-10 codes were mapped to SNOMED and Read v2 codes using the CALIBER R package\nand Technology Reference Update Distribution NHS Data Migration tables [2] to produce\nnew code lists suitable for primary care data. These resulting code lists were screened\nby two sub-specialists to ensure conditions were chronic and in the correct subgroup\nwith disagreements resolved by a third clinician.\n\n### References:\n\n1. Hardelid P, Dattani N, Gilbert R. Estimating the prevalence of chronic conditions in children who die in England, Scotland and Wales: a data linkage cohort study. BMJ Open 2014; 4: e005331.\n2. CALIBER codelists-package: Generate ICD, Read and OPCS codelists in CALIBER codelists: Generate ICD10, Read and OPCS codelists, [https://rdrr.io/rforge/CALIBERcodelists/man/CALIBERcodelists-package.html](https://rdrr.io/rforge/CALIBERcodelists/man/CALIBERcodelists-package.html) (accessed 19 October 2022).\n\n",
    "implementation": "We have considered conditions to be active if they had been coded for in the preceding\nfive years. In addition, conditions from the following subgroups were considered\nto be permanent, therefore active if coded for at any time: metabolic, diabetes,\ncystic fibrosis, transplant, receiving palliative care, other congenital multisystem\nsyndromes and chromosomal abnormalities, immunological and cerebral palsy / paralysis\n(a subgroup of \"Other neurology\" code list).\n",
    "publications": [],
    "validation": "",
    "citation_requirements": "To our knowledge, these are the first set of harmonised code lists for chronic paediatric\nconditions that span commonly used primary and secondary care coding systems in the\nUK. We hope they will prove a valuable resource for the paediatric research community\nand welcome suggestions for further development ([Olivia.Swann@ed.ac.uk](mailto:Olivia.Swann@ed.ac.uk)).\n",
    "created": "2025-01-19T16:22:04.043050Z",
    "author": "Swann OV, Williams TC, Fraser LK, Farrell J, Parker M, Kennedy J, Seabourne M, Brophy S, Harrison EM, Docherty AB, Pollock L",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 2,
    "updated": "2025-01-19T16:22:04.021742Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": [
      {
        "name": "Paediatrics",
        "value": 842203
      },
      {
        "name": "Paediatric and Perinatal Pathology",
        "value": 842275
      }
    ],
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "Hospital Episode Statistics Admitted Patient Care",
        "value": 2,
        "uid": "6599230a-df54-4615-937c-d724d239491f",
        "url": "https://healthdatagateway.org/en/dataset/875",
        "datasource_id": 875
      },
      {
        "name": "OpenSAFELY SNOMED CT",
        "value": 36,
        "datasource_id": 36
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care",
        "value": 41,
        "uid": "33fc3ffd-aa4c-4a16-a32f-0c900aaea3d2",
        "url": "https://healthdatagateway.org/en/dataset/355",
        "datasource_id": 355
      }
    ],
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "2021/01/01 - 2021/01/01",
    "concept_information": [
      {
        "concept_id": 4152,
        "concept_version_id": 11512,
        "concept_name": "Immunological (ICD-10)",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1706",
        "phenotype_version_id": 3631,
        "phenotype_name": "Chronic paediatric conditions: Immunological",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "D71",
            "description": "Functional disorders of polymorphonuclear neutrophils",
            "attributes": null
          },
          {
            "code": "D72",
            "description": "Other disorders of white blood cells",
            "attributes": null
          },
          {
            "code": "D720",
            "description": "Genetic anomalies of leukocytes",
            "attributes": null
          },
          {
            "code": "D728",
            "description": "Other specified disorders of white blood cells",
            "attributes": null
          },
          {
            "code": "D729",
            "description": "Disorder of white blood cells, unspecified",
            "attributes": null
          },
          {
            "code": "D800",
            "description": "Hereditary hypogammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "D801",
            "description": "Nonfamilial hypogammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "D802",
            "description": "Selective deficiency of immunoglobulin A [IgA]",
            "attributes": null
          },
          {
            "code": "D803",
            "description": "Selective deficiency of immunoglobulin G [IgG] subclasses",
            "attributes": null
          },
          {
            "code": "D804",
            "description": "Selective deficiency of immunoglobulin M [IgM]",
            "attributes": null
          },
          {
            "code": "D805",
            "description": "Immunodeficiency with increased immunoglobulin M",
            "attributes": null
          },
          {
            "code": "D808",
            "description": "Other immunodeficiencies with predominantly antibody defects",
            "attributes": null
          },
          {
            "code": "D809",
            "description": "Immunodeficiency with predominantly antibody defects, unspecified",
            "attributes": null
          },
          {
            "code": "D81",
            "description": "Combined immunodeficiencies",
            "attributes": null
          },
          {
            "code": "D810",
            "description": "Severe combined immunodeficiency [SCID] with reticular dysgenesis",
            "attributes": null
          },
          {
            "code": "D811",
            "description": "Severe combined immunodeficiency [SCID] with low T- and B-cell numbers",
            "attributes": null
          },
          {
            "code": "D812",
            "description": "Severe combined immunodeficiency [SCID] with low or normal B-cell numbers",
            "attributes": null
          },
          {
            "code": "D813",
            "description": "Adenosine deaminase [ADA] deficiency",
            "attributes": null
          },
          {
            "code": "D814",
            "description": "Nezelof syndrome",
            "attributes": null
          },
          {
            "code": "D815",
            "description": "Purine nucleoside phosphorylase [PNP] deficiency",
            "attributes": null
          },
          {
            "code": "D816",
            "description": "Major histocompatibility complex class I deficiency",
            "attributes": null
          },
          {
            "code": "D817",
            "description": "Major histocompatibility complex class II deficiency",
            "attributes": null
          },
          {
            "code": "D818",
            "description": "Other combined immunodeficiencies",
            "attributes": null
          },
          {
            "code": "D819",
            "description": "Combined immunodeficiency, unspecified",
            "attributes": null
          },
          {
            "code": "D82",
            "description": "Immunodeficiency associated with other major defects",
            "attributes": null
          },
          {
            "code": "D820",
            "description": "Wiskott-Aldrich syndrome",
            "attributes": null
          },
          {
            "code": "D821",
            "description": "Di George syndrome",
            "attributes": null
          },
          {
            "code": "D822",
            "description": "Immunodeficiency with short-limbed stature",
            "attributes": null
          },
          {
            "code": "D823",
            "description": "Immunodeficiency following hereditary defective response to Epstein-Barr virus",
            "attributes": null
          },
          {
            "code": "D824",
            "description": "Hyperimmunoglobulin E [IgE] syndrome",
            "attributes": null
          },
          {
            "code": "D828",
            "description": "Immunodeficiency associated with other specified major defects",
            "attributes": null
          },
          {
            "code": "D829",
            "description": "Immunodeficiency associated with major defect, unspecified",
            "attributes": null
          },
          {
            "code": "D83",
            "description": "Common variable immunodeficiency",
            "attributes": null
          },
          {
            "code": "D830",
            "description": "Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function",
            "attributes": null
          },
          {
            "code": "D831",
            "description": "Common variable immunodeficiency with predominant immunoregulatory T-cell disorders",
            "attributes": null
          },
          {
            "code": "D832",
            "description": "Common variable immunodeficiency with autoantibodies to B- or T-cells",
            "attributes": null
          },
          {
            "code": "D838",
            "description": "Other common variable immunodeficiencies",
            "attributes": null
          },
          {
            "code": "D839",
            "description": "Common variable immunodeficiency, unspecified",
            "attributes": null
          },
          {
            "code": "D84",
            "description": "Other immunodeficiencies",
            "attributes": null
          },
          {
            "code": "D840",
            "description": "Lymphocyte function antigen-1 [LFA-1] defect",
            "attributes": null
          },
          {
            "code": "D841",
            "description": "Defects in the complement system",
            "attributes": null
          },
          {
            "code": "D848",
            "description": "Other specified immunodeficiencies",
            "attributes": null
          },
          {
            "code": "D849",
            "description": "Immunodeficiency, unspecified",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 4153,
        "concept_version_id": 11513,
        "concept_name": "Immunological (Read v2)",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH1706",
        "phenotype_version_id": 3631,
        "phenotype_name": "Chronic paediatric conditions: Immunological",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "C30yy11",
            "description": "Adenosine-deaminase deficiency",
            "attributes": null
          },
          {
            "code": "C373C00",
            "description": "AL amyloidosis",
            "attributes": null
          },
          {
            "code": "C376000",
            "description": "Hereditary angio-oedema",
            "attributes": null
          },
          {
            "code": "C390.00",
            "description": "Deficiencies of humoral immunity",
            "attributes": null
          },
          {
            "code": "C390000",
            "description": "Hypogammaglobulinaemia NOS",
            "attributes": null
          },
          {
            "code": "C390100",
            "description": "Selective IgA immunodeficiency",
            "attributes": null
          },
          {
            "code": "C390.11",
            "description": "Agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390200",
            "description": "Selective IgM immunodeficiency",
            "attributes": null
          },
          {
            "code": "C390300",
            "description": "Selective IgG immunodeficiency",
            "attributes": null
          },
          {
            "code": "C390500",
            "description": "Congenital hypogammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390511",
            "description": "Bruton's agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390512",
            "description": "Congenital X-linked agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390513",
            "description": "Congenital sex-linked agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390600",
            "description": "Immunodeficiency with IgM hypergammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C390700",
            "description": "Common variable immunodeficiency",
            "attributes": null
          },
          {
            "code": "C390900",
            "description": "Agammaglobulinaemia NEC",
            "attributes": null
          },
          {
            "code": "C390A00",
            "description": "Dysimmunoglobulinaemia NEC",
            "attributes": null
          },
          {
            "code": "C390A11",
            "description": "Dysgammaglobulinaemia NEC",
            "attributes": null
          },
          {
            "code": "C390C00",
            "description": "Immunoglobulin G4 deficiency",
            "attributes": null
          },
          {
            "code": "C390C11",
            "description": "IgG4 deficiency",
            "attributes": null
          },
          {
            "code": "C390y00",
            "description": "Other specified deficiency of humoral immunity",
            "attributes": null
          },
          {
            "code": "C390z00",
            "description": "Deficiency of humoral immunity NOS",
            "attributes": null
          },
          {
            "code": "C391100",
            "description": "Di George syndrome",
            "attributes": null
          },
          {
            "code": "C391200",
            "description": "Wiskott - Aldrich syndrome",
            "attributes": null
          },
          {
            "code": "C391211",
            "description": "Thrombocytopenic eczema with immunodeficiency",
            "attributes": null
          },
          {
            "code": "C391300",
            "description": "Nezelof's syndrome",
            "attributes": null
          },
          {
            "code": "C392.00",
            "description": "Combined immunity deficiency",
            "attributes": null
          },
          {
            "code": "C392000",
            "description": "Recessive agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C392100",
            "description": "Severe combined immunodeficiency",
            "attributes": null
          },
          {
            "code": "C392111",
            "description": "Swiss type agammaglobulinaemia",
            "attributes": null
          },
          {
            "code": "C392200",
            "description": "Thymic aplasia or dysplasia with immunodeficiency",
            "attributes": null
          },
          {
            "code": "C392300",
            "description": "Severe combined immunodefiency with reticular dysgenesis",
            "attributes": null
          },
          {
            "code": "C392400",
            "description": "Severe combined immunodeficiency with low T- and B-cell numbers",
            "attributes": null
          },
          {
            "code": "C392500",
            "description": "Severe combined immunodeficiency with low or normal B-cell numbers",
            "attributes": null
          },
          {
            "code": "C392600",
            "description": "Adenosine deaminase deficiency",
            "attributes": null
          },
          {
            "code": "C392700",
            "description": "Purine nucleoside phosphorylase deficiency",
            "attributes": null
          },
          {
            "code": "C392800",
            "description": "Major histocompatibility complex class I deficiency",
            "attributes": null
          },
          {
            "code": "C392900",
            "description": "Major histocompatibility complex class II deficiency",
            "attributes": null
          },
          {
            "code": "C392z00",
            "description": "Combined immunity deficiency NOS",
            "attributes": null
          },
          {
            "code": "C393.00",
            "description": "Unspecified immunity deficiency",
            "attributes": null
          },
          {
            "code": "C396.00",
            "description": "Immunodeficiency following hereditary defective response to Epstein-Barr virus",
            "attributes": null
          },
          {
            "code": "C397.00",
            "description": "Hyperimmunoglobulin E syndrome",
            "attributes": null
          },
          {
            "code": "C398.00",
            "description": "Common variable immunodeficiency",
            "attributes": null
          },
          {
            "code": "C398000",
            "description": "Common variable immunodeficiency with predominant abnormalities of B-cell numbers and functions",
            "attributes": null
          },
          {
            "code": "C398100",
            "description": "Common variable immunodeficiency with predominant immunoregulatory T-cell disorders",
            "attributes": null
          },
          {
            "code": "C398200",
            "description": "Common variable immunodeficiency with autoantibodies to B- or T-cells",
            "attributes": null
          },
          {
            "code": "C399.00",
            "description": "Defects in the complement system",
            "attributes": null
          },
          {
            "code": "C399000",
            "description": "Mannose-binding lectin deficiency",
            "attributes": null
          },
          {
            "code": "C39X.00",
            "description": "Immunodeficiency associated with major defect, unspecified",
            "attributes": null
          },
          {
            "code": "C39y000",
            "description": "Lymphocyte function antigen-1 defect",
            "attributes": null
          },
          {
            "code": "Cyu0000",
            "description": "[X]Other immunodeficiencies with predominantly antibody defects",
            "attributes": null
          },
          {
            "code": "Cyu0100",
            "description": "[X]Other combined immunodeficiency disorders",
            "attributes": null
          },
          {
            "code": "Cyu0200",
            "description": "[X]Immunodeficiency associated with other specified major defects",
            "attributes": null
          },
          {
            "code": "Cyu0300",
            "description": "[X]Immunodeficiency associated with major defect, unspecified",
            "attributes": null
          },
          {
            "code": "Cyu0400",
            "description": "[X]Other common variable immunodeficiencies",
            "attributes": null
          },
          {
            "code": "Cyu0500",
            "description": "[X]Other specified immunodeficiency disorders",
            "attributes": null
          },
          {
            "code": "D401.00",
            "description": "Functional disorders of polymorphonuclear neutrophils",
            "attributes": null
          },
          {
            "code": "D401000",
            "description": "Congenital dysphagocytosis",
            "attributes": null
          },
          {
            "code": "D401.11",
            "description": "Job's syndrome",
            "attributes": null
          },
          {
            "code": "D401200",
            "description": "Chronic granulomatous disease",
            "attributes": null
          },
          {
            "code": "D401z00",
            "description": "Polymorphonuclear neutrophil disorder NOS",
            "attributes": null
          },
          {
            "code": "D402.00",
            "description": "Genetic leukocyte anomalies",
            "attributes": null
          },
          {
            "code": "D402.13",
            "description": "Genetic leucocyte anomalies",
            "attributes": null
          },
          {
            "code": "M15y300",
            "description": "Leiner's disease",
            "attributes": null
          },
          {
            "code": "PJ3y000",
            "description": "Shprintzen syndrome",
            "attributes": null
          },
          {
            "code": "PJ3y011",
            "description": "Velocardiofacial syndrome",
            "attributes": null
          },
          {
            "code": "SN51000",
            "description": "Acquired C1 esterase inhibitor deficiency",
            "attributes": null
          },
          {
            "code": "SN51100",
            "description": "Hereditary C1 esterase inhibitor deficiency",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 4154,
        "concept_version_id": 11514,
        "concept_name": "Immunological (SNOMED-CT)",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH1706",
        "phenotype_version_id": 3631,
        "phenotype_name": "Chronic paediatric conditions: Immunological",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "103075007",
            "description": "Humoral immune defect (finding)",
            "attributes": null
          },
          {
            "code": "103077004",
            "description": "Immunodeficiency secondary to neoplasm (disorder)",
            "attributes": null
          },
          {
            "code": "103078009",
            "description": "Immunodeficiency secondary to trauma (disorder)",
            "attributes": null
          },
          {
            "code": "103079001",
            "description": "Immunodeficiency caused by corticosteroid (disorder)",
            "attributes": null
          },
          {
            "code": "103080003",
            "description": "Immunodeficiency secondary to radiation therapy (disorder)",
            "attributes": null
          },
          {
            "code": "103081004",
            "description": "Immunodeficiency secondary to chemotherapy (disorder)",
            "attributes": null
          },
          {
            "code": "111587007",
            "description": "Severe combined immunodeficiency due to absent interleukin-2 receptor (disorder)",
            "attributes": null
          },
          {
            "code": "116133005",
            "description": "Congenital agammaglobulinemia (disorder)",
            "attributes": null
          },
          {
            "code": "119249001",
            "description": "Agammaglobulinemia (finding)",
            "attributes": null
          },
          {
            "code": "119250001",
            "description": "Hypogammaglobulinemia (finding)",
            "attributes": null
          },
          {
            "code": "123785006",
            "description": "Immunoglobulin G subclass deficiency (finding)",
            "attributes": null
          },
          {
            "code": "124274002",
            "description": "Deficiency of adenine phosphoribosyltransferase (disorder)",
            "attributes": null
          },
          {
            "code": "124281009",
            "description": "Deficiency of dimethylallyltranstransferase (disorder)",
            "attributes": null
          },
          {
            "code": "124450003",
            "description": "Deficiency of deoxyribonuclease I (disorder)",
            "attributes": null
          },
          {
            "code": "124517001",
            "description": "Deficiency of allantoinase (disorder)",
            "attributes": null
          },
          {
            "code": "124521008",
            "description": "Deficiency of adenine deaminase (disorder)",
            "attributes": null
          },
          {
            "code": "124703008",
            "description": "Deficiency of cholate-CoA ligase (disorder)",
            "attributes": null
          },
          {
            "code": "124950009",
            "description": "Deficiency of immunoglobulin (disorder)",
            "attributes": null
          },
          {
            "code": "12631000119106",
            "description": "Immunoglobulin G deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "12814002",
            "description": "B lymphocyte disorder (disorder)",
            "attributes": null
          },
          {
            "code": "129644003",
            "description": "Myeloperoxidase deficiency syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "15012007",
            "description": "Granulocyte abnormality due to immune defect (disorder)",
            "attributes": null
          },
          {
            "code": "16318001000119107",
            "description": "Hypogammaglobulinemia due to multiple myeloma (disorder)",
            "attributes": null
          },
          {
            "code": "18827005",
            "description": "Complement abnormality (disorder)",
            "attributes": null
          },
          {
            "code": "190979003",
            "description": "Selective immunoglobulin A deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "190980000",
            "description": "Selective immunoglobulin M deficiency (disorder)",
            "attributes": null
          },
          {
            "code": "190981001",
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            "code": "190993005",
            "description": "Autosomal recessive severe combined immunodeficiency (disorder)",
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            "code": "190995003",
            "description": "Thymic aplasia or dysplasia with immunodeficiency (disorder)",
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            "code": "190996002",
            "description": "Severe combined immunodeficiency with reticular dysgenesis (disorder)",
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            "code": "190997006",
            "description": "Severe combined immunodeficiency with low T- and B-cell numbers (disorder)",
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            "code": "190998001",
            "description": "Severe combined immunodeficiency with low or normal B-cell numbers (disorder)",
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            "code": "191001007",
            "description": "Major histocompatibility complex class I deficiency (disorder)",
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            "code": "191002000",
            "description": "Major histocompatibility complex class II deficiency (disorder)",
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            "description": "Immunodeficiency following hereditary defective response to Epstein-Barr virus (disorder)",
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            "description": "Common variable immunodeficiency with predominant abnormalities of B-cell numbers and functions (disorder)",
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            "code": "191012007",
            "description": "Common variable immunodeficiency with predominant immunoregulatory T-cell disorders (disorder)",
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            "description": "Common variable immunodeficiency with autoantibodies to B- or T-cells (disorder)",
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            "description": "Neutrophil cytomatrix disorder (disorder)",
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            "code": "22406001",
            "description": "Severe combined immunodeficiency due to absent lymphoid stem cells (disorder)",
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            "description": "Amyloid light-chain amyloidosis (disorder)",
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            "code": "23238000",
            "description": "Common variable agammaglobulinemia (disorder)",
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            "code": "234403002",
            "description": "Phosphoglycerokinase deficiency (disorder)",
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            "code": "234416002",
            "description": "X-linked hypogammaglobulinemia (disorder)",
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            "description": "Chemotactic disorder (disorder)",
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            "code": "234430007",
            "description": "CR3-receptor deficiency (disorder)",
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            "code": "234431006",
            "description": "Specific granule deficiency (disorder)",
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            "code": "234433009",
            "description": "Myeloperoxidase deficiency (disorder)",
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            "code": "234532001",
            "description": "Immunodeficiency disorder (disorder)",
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            "code": "234533006",
            "description": "X-linked agammaglobulinemia with growth hormone deficiency (disorder)",
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            "code": "234534000",
            "description": "Autosomal agammaglobulinemia with absent B-cells (disorder)",
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            "code": "234538002",
            "description": "Hyperimmunoglobulin D with periodic fever (finding)",
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            "code": "234539005",
            "description": "Immunoglobulin heavy chain deficiency (disorder)",
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            "code": "234540007",
            "description": "Selective immunoglobulin E deficiency (disorder)",
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            "code": "234541006",
            "description": "Selective immunoglobulin D deficiency (disorder)",
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            "code": "234542004",
            "description": "Selective immunoglobulin M and immunoglobulin A deficiency (disorder)",
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            "code": "234543009",
            "description": "Immunoglobulin light chain deficiency (disorder)",
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            "code": "234544003",
            "description": "Immunoglobulin subclass deficiency (disorder)",
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            "code": "234546001",
            "description": "Immunoglobulin G2 deficiency (disorder)",
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            "code": "234547005",
            "description": "Combined immunoglobulin G2 and G4 deficiency (disorder)",
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            "code": "234548000",
            "description": "Immunoglobulin G3 deficiency (disorder)",
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            "code": "234549008",
            "description": "Immunoglobulin G4 deficiency (disorder)",
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            "code": "234550008",
            "description": "Immunoglobulin G1 deficiency (disorder)",
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            "code": "234551007",
            "description": "Immunoglobulin A1 deficiency (disorder)",
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            "code": "234552000",
            "description": "Immunoglobulin A2 deficiency (disorder)",
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            "code": "234553005",
            "description": "Immunoglobulin-associated molecule deficiency (disorder)",
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            "code": "234554004",
            "description": "Secretory piece deficiency (disorder)",
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            "code": "234555003",
            "description": "Defective immunoglobulin glycosylation (disorder)",
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            "code": "234556002",
            "description": "Specific antibody deficiency (disorder)",
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            "description": "Anti-polysaccharide antibody deficiency (disorder)",
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            "description": "Anti-haemophilus influenzae B polysaccharide antibody deficiency (disorder)",
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            "description": "Anti-pneumococcal polysaccharide antibody deficiency (disorder)",
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            "description": "Anti-meningococcal polysaccharide A antibody deficiency (disorder)",
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            "description": "Anti-meningococcal polysaccharide C antibody deficiency (disorder)",
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            "description": "Anti-protein antibody deficiency (disorder)",
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            "description": "Anti-staphylococcal antibody deficiency (disorder)",
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            "description": "Benign combined immunodeficiency (disorder)",
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            "description": "Mannan-binding protein deficiency (disorder)",
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            "description": "Neutrophil secondary granule deficiency (disorder)",
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            "description": "Classical complement pathway abnormality (disorder)",
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            "code": "234594002",
            "description": "Complement 1q deficiency (disorder)",
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            "code": "234595001",
            "description": "Complement 1q beta chain deficiency (disorder)",
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            "description": "Complement 1q dysfunction (disorder)",
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            "code": "234597009",
            "description": "Complement 1r deficiency (disorder)",
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            "code": "234598004",
            "description": "Complement 1s deficiency (disorder)",
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            "code": "234599007",
            "description": "Complement 2 deficiency (disorder)",
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            "description": "Complement 4 deficiency (disorder)",
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            "description": "Complement 4A deficiency (disorder)",
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            "description": "Complement 4B deficiency (disorder)",
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            "code": "234604001",
            "description": "Alternative pathway deficiency (disorder)",
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            "description": "Factor D deficiency (disorder)",
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            "description": "Terminal component deficiency (disorder)",
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            "description": "Complement 5 deficiency (disorder)",
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            "description": "Complement 6 deficiency (disorder)",
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            "description": "Complement 7 deficiency (disorder)",
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            "description": "Combined complement 6 and 7 deficiencies (disorder)",
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            "description": "Complement 8 beta chain deficiency (disorder)",
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            "description": "Complement 8 beta chain dysfunction (disorder)",
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            "description": "Hereditary C1 esterase inhibitor deficiency - deficient factor (disorder)",
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            "description": "Hereditary C1 esterase inhibitor deficiency - dysfunctional factor (disorder)",
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            "description": "Decay accelerating factor deficiency (disorder)",
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            "description": "Homologous restriction factor deficiency (disorder)",
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            "description": "Anaphylotoxin inactivator deficiency (disorder)",
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            "description": "Complement receptor 1 deficiency (disorder)",
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            "description": "Transient immunodeficiency of infancy (disorder)",
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            "description": "Drug-induced immunodeficiency (disorder)",
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            "description": "Combined immunodeficiency disease (disorder)",
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            "description": "T lymphocyte disorder (disorder)",
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            "description": "Kappa light chain deficiency (disorder)",
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            "description": "Lambda light chain deficiency (disorder)",
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            "description": "Adenosine deaminase deficiency (disorder)",
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            "description": "Interleukin-12 deficiency (disorder)",
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            "description": "Severe combined immunodeficiency due to absent interleukin-2 production (disorder)",
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            "description": "Kappa light chain disease (disorder)",
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            "description": "Severe combined immunodeficiency due to absent T cell receptor (disorder)",
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            "description": "Job's syndrome (disorder)",
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            "description": "Light chain disease (disorder)",
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            "description": "Nezelof's syndrome (disorder)",
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            "description": "Primary immune deficiency disorder (disorder)",
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            "description": "X-linked agammaglobulinemia (disorder)",
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            "description": "Lambda light chain disease (disorder)",
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            "description": "Interleukin-1 receptor-associated kinase 4 deficiency (disorder)",
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            "description": "Combined immunodeficiency due to Zeta-chain associated protein kinase 70 deficiency (disorder)",
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            "code": "718107000",
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          {
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            "description": "Recurrent Neisseria infection due to factor D deficiency (disorder)",
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            "description": "Hyperimmunoglobulin M syndrome with susceptibility to opportunistic infection (disorder)",
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            "description": "Hyperimmunoglobulin M syndrome without susceptibility to opportunistic infection (disorder)",
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          {
            "code": "840472009",
            "description": "Deficiency of immunoglobulin A with immunoglobulin G subclass deficiency (disorder)",
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        ]
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    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/wmkf-ys09",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "farrellj",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 3631,
        "version_name": "Chronic paediatric conditions: Immunological",
        "version_date": "2025-01-19T16:22:04.056875Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]