[
  {
    "phenotype_id": "PH1832",
    "phenotype_version_id": 4393,
    "name": "Multiple valve disease",
    "definition": "",
    "implementation": "",
    "publications": [
      {
        "doi": "10.2139/ssrn.5203816",
        "details": "Allara E, et al. Burden of cardiovascular diseases from the COVID-19 pandemic to 2024: a national cohort in NHS England. The Lancet.",
        "primary": 1
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2025-06-10T11:43:53.951267Z",
    "author": "Elias Allara, Wen Shi, Thomas Bolton, Fionna Chalmers, Luigi Filippo Brizzi, Liam Musto, Anoop S.V. Shah, Christopher Tomlinson, Isabel Walter, Nathalie Conrad, John Danesh, Emanuele Di Angelantonio, Steffen E. Petersen, Kamlesh Khunti, Elena Raffetti, Genevieve Cezard, Spiros Denaxas, Angela M. Wood, William N. Whiteley",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 13,
      "slug": "bhf-data-science-centre",
      "name": "BHF Data Science Centre"
    },
    "world_access": 2,
    "updated": "2025-06-10T14:56:42.050140Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": [],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": null,
    "endorsements": [],
    "project_name": "CCU072_01",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": "Elias Allara",
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 4417,
        "concept_version_id": 11778,
        "concept_name": "Multiple valve disease",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1832",
        "phenotype_version_id": 4393,
        "phenotype_name": "Multiple valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I080",
            "description": "Disorders of both mitral and aortic valves",
            "attributes": null
          },
          {
            "code": "I081",
            "description": "Disorders of both mitral and tricuspid valves",
            "attributes": null
          },
          {
            "code": "I082",
            "description": "Disorders of both aortic and tricuspid valves",
            "attributes": null
          },
          {
            "code": "I083",
            "description": "Combined disorders of mitral, aortic and tricuspid valves",
            "attributes": null
          },
          {
            "code": "I088",
            "description": "Other multiple valve diseases",
            "attributes": null
          },
          {
            "code": "I089",
            "description": "Multiple valve disease, unspecified",
            "attributes": null
          },
          {
            "code": "I394",
            "description": "Multiple valve disorders in diseases classified elsewhere",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 4418,
        "concept_version_id": 11779,
        "concept_name": "Multiple valve disease",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH1832",
        "phenotype_version_id": 4393,
        "phenotype_name": "Multiple valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "16440002",
            "description": "Rheumatic disease of mitral AND aortic valves",
            "attributes": null
          },
          {
            "code": "194732001",
            "description": "Diseases of mitral and aortic valves",
            "attributes": null
          },
          {
            "code": "194734000",
            "description": "Mitral stenosis and aortic insufficiency",
            "attributes": null
          },
          {
            "code": "194736003",
            "description": "Mitral and aortic incompetence",
            "attributes": null
          },
          {
            "code": "195003002",
            "description": "Disorders of both aortic and tricuspid valves",
            "attributes": null
          },
          {
            "code": "195005009",
            "description": "Combined disorders of mitral, aortic and tricuspid valves",
            "attributes": null
          },
          {
            "code": "21849008",
            "description": "Triple valve replacement",
            "attributes": null
          },
          {
            "code": "232948007",
            "description": "Replacement of truncal valve",
            "attributes": null
          },
          {
            "code": "232949004",
            "description": "Homograft truncal valve replacement",
            "attributes": null
          },
          {
            "code": "232950004",
            "description": "Xenograft truncal valve replacement",
            "attributes": null
          },
          {
            "code": "232951000",
            "description": "Mechanical prosthetic truncal valve replacement",
            "attributes": null
          },
          {
            "code": "232955009",
            "description": "Replacement of implanted truncal valve",
            "attributes": null
          },
          {
            "code": "233601000000100",
            "description": "Aortic root replacement using pulmonary valve autograft with right ventricle to pulmonary artery valved conduit and aortoventriculoplasty",
            "attributes": null
          },
          {
            "code": "253374008",
            "description": "Congenital abnormality of atrioventricular valves and atrioventricular septal defect",
            "attributes": null
          },
          {
            "code": "253578007",
            "description": "Congenital abnormality of arterial valves",
            "attributes": null
          },
          {
            "code": "253579004",
            "description": "Truncal valve abnormality",
            "attributes": null
          },
          {
            "code": "253581002",
            "description": "Truncal valve stenosis",
            "attributes": null
          },
          {
            "code": "253582009",
            "description": "Truncal valve regurgitation",
            "attributes": null
          },
          {
            "code": "253583004",
            "description": "Truncal valve prolapse",
            "attributes": null
          },
          {
            "code": "253584005",
            "description": "Accessory tissue on truncal valve cusp",
            "attributes": null
          },
          {
            "code": "308672005",
            "description": "Biological truncal valve replacement",
            "attributes": null
          },
          {
            "code": "308673000",
            "description": "Ball valve truncal valve replacement",
            "attributes": null
          },
          {
            "code": "308674006",
            "description": "Disc valve truncal valve replacement",
            "attributes": null
          },
          {
            "code": "308675007",
            "description": "Single leaflet truncal valve replacement",
            "attributes": null
          },
          {
            "code": "308676008",
            "description": "Bileaflet truncal valve replacement",
            "attributes": null
          },
          {
            "code": "370141003",
            "description": "Rheumatic mitral AND aortic valve obstruction",
            "attributes": null
          },
          {
            "code": "37119005",
            "description": "Double valve replacement with valvuloplasty of one valve",
            "attributes": null
          },
          {
            "code": "41371000119100",
            "description": "Shone complex",
            "attributes": null
          },
          {
            "code": "428501002",
            "description": "Replacement of aortic root using pulmonary valve autograft with right ventricle to pulmonary artery valved conduit",
            "attributes": null
          },
          {
            "code": "447681003",
            "description": "Continuity between mitral valve and pulmonary valve",
            "attributes": null
          },
          {
            "code": "447682005",
            "description": "Discontinuity between mitral valve and aortic valve",
            "attributes": null
          },
          {
            "code": "448102009",
            "description": "Quadricuspid truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "448118003",
            "description": "Atrioventricular septal defect with atrial and ventricular components and separate atrioventricular valves (disorder)",
            "attributes": null
          },
          {
            "code": "448729006",
            "description": "Common atrioventricular valve in functionally univentricular heart (disorder)",
            "attributes": null
          },
          {
            "code": "448780007",
            "description": "Ventricular septal defect with absent outlet septum and overriding truncal valve with extension of membranous septum (disorder)",
            "attributes": null
          },
          {
            "code": "448793002",
            "description": "Bicuspid truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "448821004",
            "description": "Abnormality of truncal valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "448827000",
            "description": "Ventricular septal defect with absent outlet septum and overriding truncal valve with inferior muscular rim (disorder)",
            "attributes": null
          },
          {
            "code": "449037002",
            "description": "Truncal valve overriding ventricular septum (disorder)",
            "attributes": null
          },
          {
            "code": "449139001",
            "description": "Commissural fusion of truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "449544002",
            "description": "Deficiency of truncal valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "449564007",
            "description": "Fenestration of truncal valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "457707000",
            "description": "Thrombosis of truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "457712004",
            "description": "Calcification of truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "457717005",
            "description": "Perforation of truncal valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "457722005",
            "description": "Rupture of truncal valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "457727004",
            "description": "Thrombosis of common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "457732003",
            "description": "Calcification of common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "458038006",
            "description": "Abscess of truncal valve (disorder)",
            "attributes": null
          },
          {
            "code": "459154003",
            "description": "Infective endocarditis of truncal valve",
            "attributes": null
          },
          {
            "code": "459162006",
            "description": "Abscess of common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "459178008",
            "description": "Infective endocarditis of common atrioventricular valve",
            "attributes": null
          },
          {
            "code": "472834000",
            "description": "Disorder of truncal valve prosthesis",
            "attributes": null
          },
          {
            "code": "472852000",
            "description": "Regurgitation of fetal common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "472853005",
            "description": "Stenosis of fetal common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "472854004",
            "description": "Regurgitation of foetal truncal valve",
            "attributes": null
          },
          {
            "code": "472855003",
            "description": "Stenosis of foetal truncal valve",
            "attributes": null
          },
          {
            "code": "59464004",
            "description": "Rheumatic mitral AND aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "71799002",
            "description": "Rheumatic mitral valve stenosis AND aortic valve insufficiency",
            "attributes": null
          },
          {
            "code": "723448007",
            "description": "Polyvalvular heart disease syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "726335002",
            "description": "Common atrioventricular junction (disorder)",
            "attributes": null
          },
          {
            "code": "80685005",
            "description": "Double valve replacement with commissurotomy of one valve",
            "attributes": null
          },
          {
            "code": "81762006",
            "description": "Double valve replacement",
            "attributes": null
          },
          {
            "code": "840469002",
            "description": "Deficient mural leaflet of left ventricular component of common atrioventricular valve",
            "attributes": null
          },
          {
            "code": "840488009",
            "description": "Congenital truncal valvar regurgitation",
            "attributes": null
          },
          {
            "code": "840495000",
            "description": "Common atrioventricular junction with spontaneous fibrous closure of atrioventricular septal defect",
            "attributes": null
          },
          {
            "code": "840497008",
            "description": "Common atrioventricular valve with unbalanced commitment of valve to left ventricle",
            "attributes": null
          },
          {
            "code": "840517009",
            "description": "Atrioventricular septal defect, atrial and ventricular components with common atrioventricular valve with unbalanced commitment of valve to right ventricle",
            "attributes": null
          },
          {
            "code": "871594004",
            "description": "Congenital truncal valvar stenosis",
            "attributes": null
          },
          {
            "code": "871618005",
            "description": "Congenital dysplastic truncal valve",
            "attributes": null
          },
          {
            "code": "871622000",
            "description": "Common atrioventricular valve with unbalanced commitment of valve to ventricle",
            "attributes": null
          },
          {
            "code": "871624004",
            "description": "Common atrioventricular valve with unbalanced commitment of valve to right ventricle (disorder)",
            "attributes": null
          },
          {
            "code": "871627006",
            "description": "Common atrium with common atrioventricular junction (disorder)",
            "attributes": null
          },
          {
            "code": "871666003",
            "description": "Atypical left ventricular component of common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "871672003",
            "description": "Atypical right ventricular component of common atrioventricular valve (disorder)",
            "attributes": null
          },
          {
            "code": "880010000",
            "description": "Acquired abnormality of common atrioventricular valve following repair of biventricular atrioventricular connection",
            "attributes": null
          },
          {
            "code": "880045008",
            "description": "Acquired stenosis of right ventricular component of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "880046009",
            "description": "Acquired stenosis of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "880047000",
            "description": "Acquired stenosis of left ventricular component of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "880048005",
            "description": "Acquired regurgitation of left ventricular component of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "880049002",
            "description": "Acquired regurgitation of right ventricular component of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "880051003",
            "description": "Acquired regurgitation of common atrioventricular valve following repair of biventricular connection",
            "attributes": null
          },
          {
            "code": "890206005",
            "description": "Acquired abnormality of common atrioventricular valve following procedure (disorder)",
            "attributes": null
          },
          {
            "code": "890207001",
            "description": "Acquired common atrioventricular valve regurgitation following procedure",
            "attributes": null
          },
          {
            "code": "890402009",
            "description": "Congenital abnormality of truncal valve",
            "attributes": null
          }
        ]
      }
    ],
    "status": 1,
    "doi": null,
    "is_deleted": false,
    "publish_status": 2,
    "owner": "anna.stevenson",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 4393,
        "version_name": "Multiple valve disease",
        "version_date": "2025-07-02T10:41:05.606702Z",
        "is_published": true,
        "is_latest": true
      },
      {
        "version_id": 3941,
        "version_name": "Multiple valve disease",
        "version_date": "2025-06-10T14:56:42.069802Z",
        "is_published": true,
        "is_latest": false
      }
    ]
  }
]