[
  {
    "phenotype_id": "PH1847",
    "phenotype_version_id": 4354,
    "name": "Aortic valve disease",
    "definition": "This phenotype also used EPCC codes in its definition. These can be found at: [https://github.com/BHFDSC/CCU072_01/blob/main/phenotypes/ccu072_01_dcode_epcc_name_suppltable.csv](https://github.com/BHFDSC/CCU072_01/blob/main/phenotypes/ccu072_01_dcode_epcc_name_suppltable.csv)\n",
    "implementation": "",
    "publications": [
      {
        "doi": "10.2139/ssrn.5203816",
        "details": "Allara E, et al. Burden of cardiovascular diseases from the COVID-19 pandemic to 2024: a national cohort in NHS England. The Lancet.",
        "primary": 1
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2025-06-10T12:45:17.165479Z",
    "author": "Elias Allara, Wen Shi, Thomas Bolton, Fionna Chalmers, Luigi Filippo Brizzi, Liam Musto, Anoop S.V. Shah, Christopher Tomlinson, Isabel Walter, Nathalie Conrad, John Danesh, Emanuele Di Angelantonio, Steffen E. Petersen, Kamlesh Khunti, Elena Raffetti, Genevieve Cezard, Spiros Denaxas, Angela M. Wood, William N. Whiteley",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 13,
      "slug": "bhf-data-science-centre",
      "name": "BHF Data Science Centre"
    },
    "world_access": 2,
    "updated": "2025-06-10T14:52:36.804433Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": [],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": null,
    "endorsements": [],
    "project_name": "CCU072_01",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": "",
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 4450,
        "concept_version_id": 11811,
        "concept_name": "Aortic valve disease",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1847",
        "phenotype_version_id": 4354,
        "phenotype_name": "Aortic valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I060",
            "description": "Rheumatic aortic stenosis",
            "attributes": null
          },
          {
            "code": "I061",
            "description": "Rheumatic aortic insufficiency",
            "attributes": null
          },
          {
            "code": "I062",
            "description": "Rheumatic aortic stenosis with insufficiency",
            "attributes": null
          },
          {
            "code": "I068",
            "description": "Other rheumatic aortic valve diseases",
            "attributes": null
          },
          {
            "code": "I069",
            "description": "Rheumatic aortic valve disease, unspecified",
            "attributes": null
          },
          {
            "code": "I350",
            "description": "Aortic (valve) stenosis",
            "attributes": null
          },
          {
            "code": "I351",
            "description": "Aortic (valve) insufficiency",
            "attributes": null
          },
          {
            "code": "I352",
            "description": "Aortic (valve) stenosis with insufficiency",
            "attributes": null
          },
          {
            "code": "I358",
            "description": "Other aortic valve disorders",
            "attributes": null
          },
          {
            "code": "I359",
            "description": "Aortic valve disorder, unspecified",
            "attributes": null
          },
          {
            "code": "I391",
            "description": "Aortic valve disorders in diseases classified elsewhere",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 4451,
        "concept_version_id": 11812,
        "concept_name": "Aortic valve disease",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH1847",
        "phenotype_version_id": 4354,
        "phenotype_name": "Aortic valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "10743121000119100",
            "description": "Aortic valve disorder in mother complicating childbirth",
            "attributes": null
          },
          {
            "code": "10743121000119108",
            "description": "Aortic valve disorder in childbirth",
            "attributes": null
          },
          {
            "code": "1086011000000100",
            "description": "Transcatheter aortic valve implantation",
            "attributes": null
          },
          {
            "code": "1095181000000100",
            "description": "Sutureless aortic valve replacement",
            "attributes": null
          },
          {
            "code": "1144420008",
            "description": "Sclerosis of cusp of aortic valve",
            "attributes": null
          },
          {
            "code": "1155721005",
            "description": "Rheumatic aortic valve obstruction",
            "attributes": null
          },
          {
            "code": "12023003",
            "description": "Rheumatic disease of aortic valve",
            "attributes": null
          },
          {
            "code": "1204210003",
            "description": "Inflammation of aortic valve",
            "attributes": null
          },
          {
            "code": "1208857001",
            "description": "Periprosthetic aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "1231000119100",
            "description": "History of aortic valve replacement",
            "attributes": null
          },
          {
            "code": "125411000119107",
            "description": "History of mechanical aortic valve replacement",
            "attributes": null
          },
          {
            "code": "13689005",
            "description": "Congenital anomaly of aortic valve",
            "attributes": null
          },
          {
            "code": "174926009",
            "description": "Aortic valve: [plastic repair] or [replacement]",
            "attributes": null
          },
          {
            "code": "174927000",
            "description": "Homograft aortic valve replacement",
            "attributes": null
          },
          {
            "code": "174928005",
            "description": "Xenograft aortic valve replacement",
            "attributes": null
          },
          {
            "code": "174929002",
            "description": "Mechanical prosthetic aortic valve replacement",
            "attributes": null
          },
          {
            "code": "17759006",
            "description": "Rheumatic aortic stenosis with regurgitation",
            "attributes": null
          },
          {
            "code": "18546004",
            "description": "Congenital stenosis of aortic valve",
            "attributes": null
          },
          {
            "code": "194733006",
            "description": "Mitral and aortic stenosis",
            "attributes": null
          },
          {
            "code": "194983005",
            "description": "Aortic incompetence, non-rheumatic",
            "attributes": null
          },
          {
            "code": "194984004",
            "description": "Aortic stenosis, non-rheumatic",
            "attributes": null
          },
          {
            "code": "194987006",
            "description": "Aortic valve stenosis with insufficiency",
            "attributes": null
          },
          {
            "code": "19833008",
            "description": "Nodular calcific aortic valve stenosis",
            "attributes": null
          },
          {
            "code": "232838006",
            "description": "Autograft aortic valve replacement",
            "attributes": null
          },
          {
            "code": "232842009",
            "description": "Replacement of implanted aortic valve",
            "attributes": null
          },
          {
            "code": "232846007",
            "description": "Aortic valve replacement and replacement of ascending aorta",
            "attributes": null
          },
          {
            "code": "232847003",
            "description": "Aortic valve replacement and aortoplasty",
            "attributes": null
          },
          {
            "code": "232848008",
            "description": "Aortic valve replacement and patch aortoplasty",
            "attributes": null
          },
          {
            "code": "232849000",
            "description": "Aortic valve replacement and plication of ascending aorta",
            "attributes": null
          },
          {
            "code": "233862006",
            "description": "Calcific aortic stenosis - bicuspid valve",
            "attributes": null
          },
          {
            "code": "233863001",
            "description": "Senile aortic stenosis",
            "attributes": null
          },
          {
            "code": "233864007",
            "description": "Aortic regurgitation due to cystic medial necrosis of aorta",
            "attributes": null
          },
          {
            "code": "250973007",
            "description": "Aortic stenosis with doming",
            "attributes": null
          },
          {
            "code": "250974001",
            "description": "Prosthetic aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "250975000",
            "description": "Paraprosthetic aortic regurgitation",
            "attributes": null
          },
          {
            "code": "250976004",
            "description": "Aortic cusp regurgitation",
            "attributes": null
          },
          {
            "code": "250978003",
            "description": "Aortic valve calcification",
            "attributes": null
          },
          {
            "code": "250979006",
            "description": "Aortic valve fibrosis",
            "attributes": null
          },
          {
            "code": "250982001",
            "description": "Commissural fusion of aortic cusp",
            "attributes": null
          },
          {
            "code": "250983006",
            "description": "Bicuspid doming of aortic cusp",
            "attributes": null
          },
          {
            "code": "250984000",
            "description": "Torn aortic cusp",
            "attributes": null
          },
          {
            "code": "250985004",
            "description": "Perforated aortic cusp",
            "attributes": null
          },
          {
            "code": "253602000",
            "description": "Commissural fusion of aortic valve",
            "attributes": null
          },
          {
            "code": "253603005",
            "description": "Eccentric opening of aortic valve",
            "attributes": null
          },
          {
            "code": "253604004",
            "description": "Aortic valve dysplasia",
            "attributes": null
          },
          {
            "code": "253606002",
            "description": "Aortic valve cusp abnormality",
            "attributes": null
          },
          {
            "code": "253607006",
            "description": "Hypoplasia of aortic valve cusp",
            "attributes": null
          },
          {
            "code": "253608001",
            "description": "Accessory tissue on aortic valve cusp",
            "attributes": null
          },
          {
            "code": "253609009",
            "description": "Abnormal number of aortic valve cusps",
            "attributes": null
          },
          {
            "code": "253610004",
            "description": "Unicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "253611000",
            "description": "Quadricuspid aortic valve",
            "attributes": null
          },
          {
            "code": "253612007",
            "description": "Aortic valve cusp prolapse",
            "attributes": null
          },
          {
            "code": "26212005",
            "description": "Replacement of aortic valve",
            "attributes": null
          },
          {
            "code": "275199000",
            "description": "Ball valve aortic valve replacement",
            "attributes": null
          },
          {
            "code": "275200002",
            "description": "Disc valve aortic valve replacement",
            "attributes": null
          },
          {
            "code": "275201003",
            "description": "Single leaflet aortic valve replacement",
            "attributes": null
          },
          {
            "code": "275202005",
            "description": "Bileaflet aortic valve replacement",
            "attributes": null
          },
          {
            "code": "275213008",
            "description": "Aortic valve replacement NOS",
            "attributes": null
          },
          {
            "code": "276790000",
            "description": "Isolated aortic stenosis",
            "attributes": null
          },
          {
            "code": "278480000",
            "description": "Syphilitic endocarditis of aortic valve",
            "attributes": null
          },
          {
            "code": "28656008",
            "description": "Congenital insufficiency of aortic valve",
            "attributes": null
          },
          {
            "code": "301184001",
            "description": "Aortic valve vegetations",
            "attributes": null
          },
          {
            "code": "308663002",
            "description": "Porcine aortic valve replacement",
            "attributes": null
          },
          {
            "code": "315615007",
            "description": "Non-rheumatic aortic sclerosis",
            "attributes": null
          },
          {
            "code": "35350000",
            "description": "Implantation of aortic valve prosthesis or synthetic device",
            "attributes": null
          },
          {
            "code": "377151000000105",
            "description": "Percutaneous aortic valve replacement using fluoroscopic guidance",
            "attributes": null
          },
          {
            "code": "405550001",
            "description": "Trauma to aortic valve",
            "attributes": null
          },
          {
            "code": "427515002",
            "description": "Critical stenosis of aortic valve",
            "attributes": null
          },
          {
            "code": "429347004",
            "description": "Rheumatic aortic valve sclerosis",
            "attributes": null
          },
          {
            "code": "430065009",
            "description": "Abscess of aortic valve",
            "attributes": null
          },
          {
            "code": "432992007",
            "description": "Bacterial abscess of aortic valve",
            "attributes": null
          },
          {
            "code": "441873006",
            "description": "Percutaneous replacement of aortic valve using fluoroscopic guidance",
            "attributes": null
          },
          {
            "code": "441895005",
            "description": "Replacement of aortic valve with tissue graft",
            "attributes": null
          },
          {
            "code": "443887000",
            "description": "Grafting of aortic valve prosthesis by transapical approach",
            "attributes": null
          },
          {
            "code": "443916000",
            "description": "Grafting of aortic valve prosthesis by transluminal approach",
            "attributes": null
          },
          {
            "code": "445270008",
            "description": "Aortic orifice left side by side with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "445298006",
            "description": "Aortic orifice anterior with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "445607003",
            "description": "Aortic orifice posterior left with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "445636003",
            "description": "Aortic orifice anterior right with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "445650008",
            "description": "Aortic orifice anterior left with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "446670007",
            "description": "Aortic orifice right side by side with respect to pulmonary orifice",
            "attributes": null
          },
          {
            "code": "447671002",
            "description": "Ventricular septal defect with posterior malaligned outlet septum with overriding aortic valve",
            "attributes": null
          },
          {
            "code": "447696004",
            "description": "Unicommissural unicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "447698003",
            "description": "Ventricular septal defect with anterior malaligned outlet septum with overriding aortic valve",
            "attributes": null
          },
          {
            "code": "447822009",
            "description": "Congenital prolapse of aortic valve",
            "attributes": null
          },
          {
            "code": "447847006",
            "description": "Prolapse of right coronary aortic valve cusp",
            "attributes": null
          },
          {
            "code": "447937009",
            "description": "Congenital abnormality of aortic valve cusp",
            "attributes": null
          },
          {
            "code": "448085005",
            "description": "Acommissural unicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "448161000",
            "description": "Aortic valve overriding ventricular septum",
            "attributes": null
          },
          {
            "code": "448576004",
            "description": "Fenestration of aortic valve cusp",
            "attributes": null
          },
          {
            "code": "448634001",
            "description": "Absent aortic valve cusp",
            "attributes": null
          },
          {
            "code": "448684008",
            "description": "Prolapse of left coronary aortic valve cusp",
            "attributes": null
          },
          {
            "code": "448743001",
            "description": "Abnormality of aortic valve",
            "attributes": null
          },
          {
            "code": "448790004",
            "description": "Anterior-posterior orientation of bicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "448819009",
            "description": "Right-left orientation of bicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "448903003",
            "description": "Dilatation of annulus of aortic valve",
            "attributes": null
          },
          {
            "code": "449112009",
            "description": "Prolapse of noncoronary aortic valve cusp",
            "attributes": null
          },
          {
            "code": "449149003",
            "description": "Deficiency of aortic valve cusp",
            "attributes": null
          },
          {
            "code": "449555002",
            "description": "Aortic valve commissural abnormality",
            "attributes": null
          },
          {
            "code": "457682000",
            "description": "Obstruction of aortic valve due to neoplasm",
            "attributes": null
          },
          {
            "code": "457687006",
            "description": "Thrombosis of aortic valve",
            "attributes": null
          },
          {
            "code": "457692008",
            "description": "Disruption of aortic valve annulus",
            "attributes": null
          },
          {
            "code": "457697002",
            "description": "Dehiscence of aortic valve annulus as complication of procedure",
            "attributes": null
          },
          {
            "code": "457702006",
            "description": "Disorder of aortic valve prosthesis",
            "attributes": null
          },
          {
            "code": "459068007",
            "description": "Infective endocarditis of aortic valve",
            "attributes": null
          },
          {
            "code": "472846001",
            "description": "Regurgitation of fetal aortic valve (disorder)",
            "attributes": null
          },
          {
            "code": "472847005",
            "description": "Stenosis of fetal aortic valve",
            "attributes": null
          },
          {
            "code": "473373004",
            "description": "Calcification of aortic valve annulus",
            "attributes": null
          },
          {
            "code": "509951000000106",
            "description": "Transapical aortic valve implantation",
            "attributes": null
          },
          {
            "code": "510101000000101",
            "description": "Transluminal aortic valve implantation",
            "attributes": null
          },
          {
            "code": "51442005",
            "description": "Congenital atresia of aortic valve",
            "attributes": null
          },
          {
            "code": "52247003",
            "description": "Repair of aortic valve with tissue graft",
            "attributes": null
          },
          {
            "code": "53391000119100",
            "description": "History of tissue graft aortic valve replacement",
            "attributes": null
          },
          {
            "code": "59117006",
            "description": "Implantation of aortic valve with tissue graft",
            "attributes": null
          },
          {
            "code": "60234000",
            "description": "Aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "60573004",
            "description": "Aortic valve stenosis",
            "attributes": null
          },
          {
            "code": "609781000000108",
            "description": "Aortic valve replacement NOS",
            "attributes": null
          },
          {
            "code": "61612001",
            "description": "Syphilitic aortic incompetence",
            "attributes": null
          },
          {
            "code": "67754003",
            "description": "Aortic valve sclerosis",
            "attributes": null
          },
          {
            "code": "703169005",
            "description": "Acute prosthetic aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "703170006",
            "description": "Prosthetic aortic valve stenosis",
            "attributes": null
          },
          {
            "code": "703171005",
            "description": "Prosthetic aortic valve failure",
            "attributes": null
          },
          {
            "code": "703172003",
            "description": "Prosthetic aortic valve failure requiring revision",
            "attributes": null
          },
          {
            "code": "703173008",
            "description": "Prosthetic aortic valve failure requiring replacement",
            "attributes": null
          },
          {
            "code": "703189006",
            "description": "Endocarditis of prosthetic aortic valve",
            "attributes": null
          },
          {
            "code": "703222005",
            "description": "Postprocedural aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "703223000",
            "description": "Postprocedural aortic valve stenosis",
            "attributes": null
          },
          {
            "code": "703236000",
            "description": "Non-rheumatic aortic valve stenosis with regurgitation",
            "attributes": null
          },
          {
            "code": "703297006",
            "description": "Prosthetic aortic valve stenosis and regurgitation",
            "attributes": null
          },
          {
            "code": "703318003",
            "description": "Neoaortic valve stenosis",
            "attributes": null
          },
          {
            "code": "703323003",
            "description": "Aortic valve regurgitation due to aortic dilation",
            "attributes": null
          },
          {
            "code": "703324009",
            "description": "Aortic valve regurgitation due to trauma",
            "attributes": null
          },
          {
            "code": "703325005",
            "description": "Aortic valve regurgitation due to aortic dissection",
            "attributes": null
          },
          {
            "code": "72011007",
            "description": "Rheumatic aortic stenosis",
            "attributes": null
          },
          {
            "code": "72352009",
            "description": "Bicuspid aortic valve",
            "attributes": null
          },
          {
            "code": "725351001",
            "description": "Transcatheter aortic valve replacement",
            "attributes": null
          },
          {
            "code": "726631002",
            "description": "Computed tomography angiography with contrast for transcatheter aortic valve implantation planning",
            "attributes": null
          },
          {
            "code": "736892002",
            "description": "Aortic bi-leaflet mechanical valve prosthesis",
            "attributes": null
          },
          {
            "code": "736893007",
            "description": "Aortic tri-leaflet mechanical valve prosthesis",
            "attributes": null
          },
          {
            "code": "762539005",
            "description": "Endocarditis of neoaortic valve",
            "attributes": null
          },
          {
            "code": "764955006",
            "description": "Laubry Pezzi syndrome",
            "attributes": null
          },
          {
            "code": "770435005",
            "description": "Familial bicuspid aortic valve (disorder)",
            "attributes": null
          },
          {
            "code": "773996000",
            "description": "Transcatheter aortic valve implantation",
            "attributes": null
          },
          {
            "code": "77696009",
            "description": "Double aortic valve",
            "attributes": null
          },
          {
            "code": "78031003",
            "description": "Rheumatic aortic regurgitation",
            "attributes": null
          },
          {
            "code": "782170002",
            "description": "Computed tomography triple phase angiography with contrast for transcatheter aortic valve implantation planning",
            "attributes": null
          },
          {
            "code": "782704000",
            "description": "Replacement of aortic valve using sutureless valve",
            "attributes": null
          },
          {
            "code": "82355002",
            "description": "Syphilitic aortic stenosis",
            "attributes": null
          },
          {
            "code": "836480008",
            "description": "Mild stenosis of aortic valve",
            "attributes": null
          },
          {
            "code": "836481007",
            "description": "Moderate stenosis of aortic valve",
            "attributes": null
          },
          {
            "code": "836482000",
            "description": "Severe stenosis of aortic valve",
            "attributes": null
          },
          {
            "code": "838544003",
            "description": "Mild aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "838545002",
            "description": "Moderate aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "838546001",
            "description": "Severe aortic valve regurgitation",
            "attributes": null
          },
          {
            "code": "860667004",
            "description": "Aortic bi-leaflet mechanical valve prosthesis with biologic-polymer aorta graft",
            "attributes": null
          },
          {
            "code": "871597006",
            "description": "Congenital dysplasia of aortic valve",
            "attributes": null
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