[
  {
    "phenotype_id": "PH1854",
    "phenotype_version_id": 4408,
    "name": "Pulmonary valve disease",
    "definition": "This phenotype also used EPCC codes in its definition. These can be found at: [https://github.com/BHFDSC/CCU072_01/blob/main/phenotypes/ccu072_01_dcode_epcc_name_suppltable.csv](https://github.com/BHFDSC/CCU072_01/blob/main/phenotypes/ccu072_01_dcode_epcc_name_suppltable.csv)\n",
    "implementation": "",
    "publications": [
      {
        "doi": "10.2139/ssrn.5203816",
        "details": "Allara E, et al. Burden of cardiovascular diseases from the COVID-19 pandemic to 2024: a national cohort in NHS England. The Lancet.",
        "primary": 1
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2025-06-10T13:06:06.477456Z",
    "author": "Elias Allara, Wen Shi, Thomas Bolton, Fionna Chalmers, Luigi Filippo Brizzi, Liam Musto, Anoop S.V. Shah, Christopher Tomlinson, Isabel Walter, Nathalie Conrad, John Danesh, Emanuele Di Angelantonio, Steffen E. Petersen, Kamlesh Khunti, Elena Raffetti, Genevieve Cezard, Spiros Denaxas, Angela M. Wood, William N. Whiteley",
    "collections": [
      {
        "name": "BHF Data Science Centre",
        "value": 20
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 13,
      "slug": "bhf-data-science-centre",
      "name": "BHF Data Science Centre"
    },
    "world_access": 2,
    "updated": "2025-06-10T14:51:08.591919Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": [],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": null,
    "endorsements": [],
    "project_name": "CCU072_01",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      },
      {
        "name": "ICD10 codes",
        "value": 4
      }
    ],
    "corresp_author": "Elias Allara",
    "event_date_range": "",
    "concept_information": [
      {
        "concept_id": 4464,
        "concept_version_id": 11825,
        "concept_name": "Pulmonary valve disease",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH1854",
        "phenotype_version_id": 4408,
        "phenotype_name": "Pulmonary valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "I098",
            "description": "Other specified rheumatic heart diseases",
            "attributes": null
          },
          {
            "code": "I370",
            "description": "Pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "I371",
            "description": "Pulmonary valve insufficiency",
            "attributes": null
          },
          {
            "code": "I372",
            "description": "Pulmonary valve stenosis with insufficiency",
            "attributes": null
          },
          {
            "code": "I378",
            "description": "Other pulmonary valve disorders",
            "attributes": null
          },
          {
            "code": "I379",
            "description": "Pulmonary valve disorder, unspecified",
            "attributes": null
          },
          {
            "code": "I393",
            "description": "Pulmonary valve disorders in diseases classified elsewhere",
            "attributes": null
          }
        ]
      },
      {
        "concept_id": 4465,
        "concept_version_id": 11826,
        "concept_name": "Pulmonary valve disease",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH1854",
        "phenotype_version_id": 4408,
        "phenotype_name": "Pulmonary valve disease",
        "code_attribute_header": null,
        "codes": [
          {
            "code": "1142043006",
            "description": "Late syphilitic pulmonary regurgitation",
            "attributes": null
          },
          {
            "code": "123643003",
            "description": "Acquired atresia of pulmonary valve",
            "attributes": null
          },
          {
            "code": "13316004",
            "description": "Implantation of pulmonary valve with tissue graft",
            "attributes": null
          },
          {
            "code": "15096009",
            "description": "Congenital insufficiency of pulmonary valve",
            "attributes": null
          },
          {
            "code": "174943007",
            "description": "Pulmonary valve: [plastic repair] or [replacement]",
            "attributes": null
          },
          {
            "code": "174944001",
            "description": "Homograft pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "174945000",
            "description": "Xenograft pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "174946004",
            "description": "Mechanical prosthetic pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "18687009",
            "description": "Rheumatic disease of pulmonary valve",
            "attributes": null
          },
          {
            "code": "186878002",
            "description": "Syphilitic endocarditis of pulmonary valve",
            "attributes": null
          },
          {
            "code": "194995005",
            "description": "Pulmonary incompetence, non-rheumatic",
            "attributes": null
          },
          {
            "code": "194997002",
            "description": "Pulmonary stenosis, non-rheumatic",
            "attributes": null
          },
          {
            "code": "195000004",
            "description": "Pulmonary valve stenosis with insufficiency",
            "attributes": null
          },
          {
            "code": "204306007",
            "description": "Pentalogy of Fallot",
            "attributes": null
          },
          {
            "code": "204339005",
            "description": "Congenital pulmonary valve abnormality",
            "attributes": null
          },
          {
            "code": "204342004",
            "description": "Congenital atresia of the pulmonary valve",
            "attributes": null
          },
          {
            "code": "204343009",
            "description": "Hypoplasia of pulmonary valve",
            "attributes": null
          },
          {
            "code": "204345002",
            "description": "Congenital fusion of pulmonic cusps",
            "attributes": null
          },
          {
            "code": "204346001",
            "description": "Congenital fusion of pulmonary valve segment",
            "attributes": null
          },
          {
            "code": "204351007",
            "description": "Fallot's trilogy",
            "attributes": null
          },
          {
            "code": "204352000",
            "description": "Supernumerary pulmonary valve cusps",
            "attributes": null
          },
          {
            "code": "223371000000103",
            "description": "Percutaneous transluminal pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "232878004",
            "description": "Replacement of implanted pulmonary valve",
            "attributes": null
          },
          {
            "code": "233866009",
            "description": "Functional pulmonary regurgitation",
            "attributes": null
          },
          {
            "code": "236529001",
            "description": "Prune belly syndrome with pulmonic stenosis, mental retardation and deafness",
            "attributes": null
          },
          {
            "code": "236530006",
            "description": "Pulmonic stenosis and congenital nephrosis",
            "attributes": null
          },
          {
            "code": "251006007",
            "description": "Pulmonary valve stenosis with doming",
            "attributes": null
          },
          {
            "code": "251007003",
            "description": "Pulmonary valve stenosis with narrow jet",
            "attributes": null
          },
          {
            "code": "253303001",
            "description": "Solitary aortic trunk with pulmonary atresia",
            "attributes": null
          },
          {
            "code": "253512000",
            "description": "Tetralogy of Fallot with pulmonary stenosis",
            "attributes": null
          },
          {
            "code": "253513005",
            "description": "Fallot's type pulmonary atresia",
            "attributes": null
          },
          {
            "code": "253514004",
            "description": "Dextraposition of aorta in Fallot's tetralogy",
            "attributes": null
          },
          {
            "code": "253515003",
            "description": "Ventricular septal defect in Fallot's tetralogy",
            "attributes": null
          },
          {
            "code": "253562005",
            "description": "Ventricular septal defect with malaligned outlet septum and overriding truncal valve",
            "attributes": null
          },
          {
            "code": "253585006",
            "description": "Pulmonary valve cusp hypoplasia",
            "attributes": null
          },
          {
            "code": "253586007",
            "description": "Pulmonary valve ring hypoplasia",
            "attributes": null
          },
          {
            "code": "253587003",
            "description": "Commissural fusion of pulmonary valve",
            "attributes": null
          },
          {
            "code": "253588008",
            "description": "Mucoid thickening of pulmonary valve",
            "attributes": null
          },
          {
            "code": "253590009",
            "description": "PAIV - Pulmonary atresia with intact ventricular septum",
            "attributes": null
          },
          {
            "code": "253591008",
            "description": "Pulmonary atresia with ventricular septal defect",
            "attributes": null
          },
          {
            "code": "253592001",
            "description": "Pulmonary valve atresia without ventricular outflow tract",
            "attributes": null
          },
          {
            "code": "253593006",
            "description": "Imperforate pulmonary valve",
            "attributes": null
          },
          {
            "code": "253594000",
            "description": "Muscular pulmonary atresia",
            "attributes": null
          },
          {
            "code": "253595004",
            "description": "Pulmonary valve prolapse",
            "attributes": null
          },
          {
            "code": "253596003",
            "description": "APVS - Absent pulmonary valve syndrome",
            "attributes": null
          },
          {
            "code": "253597007",
            "description": "Accessory tissue on pulmonary valve cusp",
            "attributes": null
          },
          {
            "code": "253598002",
            "description": "Unicuspid pulmonary valve",
            "attributes": null
          },
          {
            "code": "253599005",
            "description": "Bicuspid pulmonary valve",
            "attributes": null
          },
          {
            "code": "253600008",
            "description": "Quadricuspid pulmonary valve",
            "attributes": null
          },
          {
            "code": "253624000",
            "description": "Pulmonary atresia with confluent pulmonary arteries",
            "attributes": null
          },
          {
            "code": "253625004",
            "description": "Pulmonary atresia with absent pulmonary artery",
            "attributes": null
          },
          {
            "code": "259261000000100",
            "description": "Percutaneous transluminal pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "275207004",
            "description": "Ball valve pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "275209001",
            "description": "Disc valve pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "275210006",
            "description": "Single leaflet pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "275211005",
            "description": "Bileaflet pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "297285002",
            "description": "Paraprosthetic pulmonary regurgitation",
            "attributes": null
          },
          {
            "code": "301106001",
            "description": "Pulmonary valve vegetations",
            "attributes": null
          },
          {
            "code": "302943003",
            "description": "Abnormal number of pulmonary valve cusps",
            "attributes": null
          },
          {
            "code": "308665009",
            "description": "Biological pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "308666005",
            "description": "Porcine pulmonary valve replacement",
            "attributes": null
          },
          {
            "code": "34126003",
            "description": "Rheumatic pulmonary valve insufficiency",
            "attributes": null
          },
          {
            "code": "377141000000107",
            "description": "Percutaneous pulmonary valve replacement using fluoroscopic guidance",
            "attributes": null
          },
          {
            "code": "399228007",
            "description": "Tetralogy of Fallot with absent pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "405552009",
            "description": "Trauma to pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "429248007",
            "description": "Percutaneous transluminal replacement of pulmonary valve",
            "attributes": null
          },
          {
            "code": "431238002",
            "description": "Abscess of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "431261000",
            "description": "Bacterial abscess of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "447670001",
            "description": "Ventricular septal defect with anterior malaligned outlet septum with overriding pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "447672009",
            "description": "Ventricular septal defect with posterior malaligned outlet septum with overriding pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "447683000",
            "description": "Discontinuity between mitral valve and pulmonary valve",
            "attributes": null
          },
          {
            "code": "447697008",
            "description": "Unicommissural unicuspid pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "447838003",
            "description": "Pulmonary atresia and ventricular septal defect with aorta from left ventricle (disorder)",
            "attributes": null
          },
          {
            "code": "447839006",
            "description": "Pulmonary atresia and ventricular septal defect with aorta from right ventricle (disorder)",
            "attributes": null
          },
          {
            "code": "448004007",
            "description": "Acommissural unicuspid pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "448155003",
            "description": "Pulmonary atresia with ventricular septal defect of Fallot type (disorder)",
            "attributes": null
          },
          {
            "code": "448413002",
            "description": "Pulmonary valve overriding ventricular septum (disorder)",
            "attributes": null
          },
          {
            "code": "448475002",
            "description": "Absent pulmonary valve syndrome with ventricular septal defect of non Fallot type (disorder)",
            "attributes": null
          },
          {
            "code": "448604006",
            "description": "Congenital abnormality of pulmonary valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "448643005",
            "description": "Abnormality of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "448946000",
            "description": "Anterior-posterior orientation of bicuspid pulmonary valve",
            "attributes": null
          },
          {
            "code": "449133000",
            "description": "Absence of pulmonary valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "449140004",
            "description": "Right-left orientation of bicuspid pulmonary valve",
            "attributes": null
          },
          {
            "code": "449186002",
            "description": "Dilatation of pulmonary valve annulus (disorder)",
            "attributes": null
          },
          {
            "code": "449354002",
            "description": "Hypoplasia of pulmonary cusps of absent pulmonary valve type (disorder)",
            "attributes": null
          },
          {
            "code": "449529003",
            "description": "Abnormality of pulmonary valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "449601008",
            "description": "Fenestration of pulmonary valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "449605004",
            "description": "Deficiency of pulmonary valve cusp (disorder)",
            "attributes": null
          },
          {
            "code": "45058001",
            "description": "Syphilis of pulmonary valve",
            "attributes": null
          },
          {
            "code": "457642007",
            "description": "Obstruction of pulmonary valve due to tumor",
            "attributes": null
          },
          {
            "code": "457647001",
            "description": "Thrombosis of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "457652006",
            "description": "Calcification of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "457657000",
            "description": "Perforation of pulmonary cusp",
            "attributes": null
          },
          {
            "code": "457662004",
            "description": "Rupture of pulmonary cusp",
            "attributes": null
          },
          {
            "code": "457667005",
            "description": "Disruption of pulmonary valve annulus (disorder)",
            "attributes": null
          },
          {
            "code": "457672001",
            "description": "Calcification of pulmonary valve annulus (disorder)",
            "attributes": null
          },
          {
            "code": "457677007",
            "description": "Dehiscence of pulmonary valve annulus as complication of procedure",
            "attributes": null
          },
          {
            "code": "459153009",
            "description": "Infective endocarditis of pulmonary valve",
            "attributes": null
          },
          {
            "code": "472833006",
            "description": "Disorder of pulmonary valve prosthesis",
            "attributes": null
          },
          {
            "code": "472844003",
            "description": "Regurgitation of fetal pulmonary valve",
            "attributes": null
          },
          {
            "code": "472845002",
            "description": "Stenosis of fetal pulmonary valve",
            "attributes": null
          },
          {
            "code": "52048004",
            "description": "Rheumatic pulmonary valve failure",
            "attributes": null
          },
          {
            "code": "56786000",
            "description": "Pulmonic valve stenosis",
            "attributes": null
          },
          {
            "code": "67278007",
            "description": "Congenital stenosis of pulmonary valve",
            "attributes": null
          },
          {
            "code": "6996004",
            "description": "Congenital absence of pulmonary valve",
            "attributes": null
          },
          {
            "code": "703178004",
            "description": "Non-rheumatic pulmonary valve stenosis with regurgitation",
            "attributes": null
          },
          {
            "code": "703181009",
            "description": "Postprocedural pulmonary valve regurgitation (disorder)",
            "attributes": null
          },
          {
            "code": "703185000",
            "description": "Neopulmonary valve regurgitation",
            "attributes": null
          },
          {
            "code": "703186004",
            "description": "Neopulmonary valve stenosis (disorder)",
            "attributes": null
          },
          {
            "code": "703187008",
            "description": "Prosthetic pulmonary valve failure (disorder)",
            "attributes": null
          },
          {
            "code": "703188003",
            "description": "Prosthetic pulmonary valve failure requiring replacement",
            "attributes": null
          },
          {
            "code": "703191003",
            "description": "Endocarditis of prosthetic pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "703192005",
            "description": "Postprocedural pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "703290008",
            "description": "Prosthetic pulmonary valve failure requiring revision (disorder)",
            "attributes": null
          },
          {
            "code": "703291007",
            "description": "Prosthetic pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "703293005",
            "description": "Prosthetic pulmonary valve regurgitation (disorder)",
            "attributes": null
          },
          {
            "code": "719955006",
            "description": "Atresia of pulmonary valve (disorder)",
            "attributes": null
          },
          {
            "code": "723336008",
            "description": "Bindewald Ulmer Muller syndrome",
            "attributes": null
          },
          {
            "code": "762433009",
            "description": "Tetralogy of Fallot with pulmonary atresia co-occurrent with systemic-to-pulmonary collateral artery",
            "attributes": null
          },
          {
            "code": "762540007",
            "description": "Endocarditis of neopulmonary valve",
            "attributes": null
          },
          {
            "code": "76267008",
            "description": "Pulmonary valve disorder",
            "attributes": null
          },
          {
            "code": "766976003",
            "description": "Pulmonary valve agenesis, tetralogy of Fallot, absence of ductus arteriosus syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "784353002",
            "description": "Pulmonary valve agenesis, intact ventricular septum, persistent ductus arteriosus syndrome (disorder)",
            "attributes": null
          },
          {
            "code": "787162002",
            "description": "Percutaneous pulmonary valve implantation",
            "attributes": null
          },
          {
            "code": "79917009",
            "description": "Implantation of pulmonary valve prosthesis or synthetic device",
            "attributes": null
          },
          {
            "code": "838538002",
            "description": "Mild pulmonary valve stenosis (disorder)",
            "attributes": null
          },
          {
            "code": "838539005",
            "description": "Moderate pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "838540007",
            "description": "Severe pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "838541006",
            "description": "Mild pulmonary valve regurgitation (disorder)",
            "attributes": null
          },
          {
            "code": "838542004",
            "description": "Moderate pulmonary valve regurgitation",
            "attributes": null
          },
          {
            "code": "838543009",
            "description": "Severe pulmonary valve regurgitation (disorder)",
            "attributes": null
          },
          {
            "code": "86299006",
            "description": "Tetralogy of Fallot",
            "attributes": null
          },
          {
            "code": "871599009",
            "description": "Double outlet right ventricle with subaortic or doubly committed ventricular septal defect and pulmonary stenosis Fallot type (disorder)",
            "attributes": null
          },
          {
            "code": "871601006",
            "description": "Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis Fallot type (disorder)",
            "attributes": null
          },
          {
            "code": "88045004",
            "description": "Replacement of pulmonary valve",
            "attributes": null
          },
          {
            "code": "91434003",
            "description": "Pulmonic valve regurgitation",
            "attributes": null
          },
          {
            "code": "91442002",
            "description": "Rheumatic pulmonary valve stenosis",
            "attributes": null
          },
          {
            "code": "92830003",
            "description": "Combined valvular-subvalvular pulmonic stenosis",
            "attributes": null
          },
          {
            "code": "92941000",
            "description": "Congenital abnormal shape of pulmonary valve",
            "attributes": null
          },
          {
            "code": "93075009",
            "description": "Congenital hypertrophy of pulmonary valve",
            "attributes": null
          },
          {
            "code": "93287006",
            "description": "Congenital hypoplasia of pulmonary valve",
            "attributes": null
          },
          {
            "code": "94461000119106",
            "description": "History of pulmonary valve replacement",
            "attributes": null
          }
        ]
      }
    ],
    "status": 1,
    "doi": null,
    "is_deleted": false,
    "publish_status": 2,
    "owner": "anna.stevenson",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 4408,
        "version_name": "Pulmonary valve disease",
        "version_date": "2025-07-02T10:41:06.665458Z",
        "is_published": true,
        "is_latest": true
      },
      {
        "version_id": 3914,
        "version_name": "Pulmonary valve disease",
        "version_date": "2025-06-10T14:51:08.618527Z",
        "is_published": true,
        "is_latest": false
      }
    ]
  }
]