[
  {
    "phenotype_id": "PH2008",
    "phenotype_version_id": 4614,
    "name": "Multimorbidity_connective tissue disorder",
    "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\nConnective tissue disorder codelists (SNOMED):\nThis codelist captures connective tissue disorders, including rheumatoid arthritis, other inflammatory polyarthropathies, and systemic connective tissue diseases—conditions grouped together under the Cambridge Multimorbidity Score.\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n",
    "implementation": null,
    "publications": null,
    "validation": null,
    "citation_requirements": null,
    "created": "2026-01-26T21:33:08.730477Z",
    "author": "University of Bristol",
    "collections": [
      {
        "name": "OpenCodelist",
        "value": 31
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 1,
      "slug": "opensafely",
      "name": "OpenSAFELY"
    },
    "world_access": 1,
    "updated": "2026-01-26T21:33:08.724427Z",
    "references": [
      {
        "url": "https://digital.nhs.uk/data-and-information/data-collections-and-data-sets/data-collections/quality-and-outcomes-framework-qof/quality-and-outcome-framework-qof-business-rules/primary-care-domain-reference-set-portal",
        "title": "Primary Care Domain Reference Set Portal"
      },
      {
        "url": "https://www.cmaj.ca/content/cmaj/192/5/e107.full.pdf",
        "title": "Payne, R. A., Mendonca, S. C., Elliott, M. N., Saunders, C. L., Edwards, D. A., Marshall, M., & Roland, M. (2020). Development and validation of the Cambridge Multimorbidity Score. Cmaj, 192(5), E107-E114."
      },
      {
        "url": "https://www.opencodelists.org/codelist/user/yayang/charlson05_connective_tissue/152e7cd1/",
        "title": "Charlson05_connective_tissue"
      }
    ],
    "signed_off": [],
    "methodology": "Codes were sourced from the `RARTHAD_COD` refset published by NHSD, and supplemented with converted codes from the original published paper and existing Charlson multimorbidity code lists.\n\n",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      }
    ],
    "open_codelist_id": "bristol/multimorbidity_connective-tissue-disorder",
    "source_reference": "https://www.opencodelists.org/codelist/bristol/multimorbidity_connective-tissue-disorder/52109c4b",
    "concept_information": [
      {
        "concept_id": 4791,
        "concept_version_id": 12276,
        "concept_name": "bristol/multimorbidity_connective-tissue-disorder/52109c4b",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH2008",
        "phenotype_version_id": 4614,
        "phenotype_name": "Multimorbidity_connective tissue disorder",
        "code_attribute_header": [],
        "codes": [
          {
            "code": "105969002",
            "description": "Disorder of connective tissue",
            "attributes": null
          },
          {
            "code": "10629311000119107",
            "description": "Psoriatic arthritis mutilans",
            "attributes": null
          },
          {
            "code": "1156765006",
            "description": "Persistent onset antinuclear antibody negative juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1156766007",
            "description": "Persistent onset antinuclear antibody positive juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1156801007",
            "description": "Macrophage activation syndrome due to juvenile systemic onset arthritis",
            "attributes": null
          },
          {
            "code": "1156817001",
            "description": "Extended oligoarticular onset antinuclear antibody positive juvenile idiopathic arthritis",
            "attributes": null
          },
          {
            "code": "1156819003",
            "description": "Extended oligoarticular onset antinuclear antibody negative juvenile idiopathic arthritis",
            "attributes": null
          },
          {
            "code": "1156843000",
            "description": "Uveitis due to persistent onset antinuclear antibody negative juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1156844006",
            "description": "Uveitis due to persistent onset antinuclear antibody positive juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1156845007",
            "description": "Uveitis due to extended onset antinuclear antibody negative juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1156846008",
            "description": "Uveitis due to extended onset antinuclear antibody positive juvenile idiopathic oligoarthritis",
            "attributes": null
          },
          {
            "code": "1162295001",
            "description": "Psoriatic arthritis of multiple joints",
            "attributes": null
          },
          {
            "code": "1162306005",
            "description": "Oligoarticular psoriatic arthritis",
            "attributes": null
          },
          {
            "code": "1212005",
            "description": "Childhood type dermatomyositis",
            "attributes": null
          },
          {
            "code": "1231259004",
            "description": "Uveitis due to juvenile idiopathic arthritis",
            "attributes": null
          },
          {
            "code": "123246003",
            "description": "Still's disease",
            "attributes": null
          },
          {
            "code": "126766000",
            "description": "Lymphoepithelial sialadenitis of Sjögren's syndrome",
            "attributes": null
          },
          {
            "code": "148071003",
            "description": "Rheumatology disorder monitoring (& arthritis [& rheumatoid])",
            "attributes": null
          },
          {
            "code": "154425004",
            "description": "Sarcoidosis",
            "attributes": null
          },
          {
            "code": "155440007",
            "description": "Polyarteritis nodosa and allied conditions",
            "attributes": null
          },
          {
            "code": "155441006",
            "description": "Polyarteritis nodosa",
            "attributes": null
          },
          {
            "code": "155445002",
            "description": "(Goodpasture's syndrome) or (Wegener's granulomatosis) or (Takayasu's disease) or (polyarteritis nodosa NOS)",
            "attributes": null
          },
          {
            "code": "156370009",
            "description": "Psoriatic arthritis",
            "attributes": null
          },
          {
            "code": "156450004",
            "description": "Systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "156451000",
            "description": "Scleroderma (& [systemic sclerosis])",
            "attributes": null
          },
          {
            "code": "156455009",
            "description": "(Sicca - Sjogren's - syndrome) or (keraconjunctivitis sicca) or (Sjogren's disease)",
            "attributes": null
          },
          {
            "code": "156457001",
            "description": "Polymyositis",
            "attributes": null
          },
          {
            "code": "156656001",
            "description": "Polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "15728921000119109",
            "description": "Disorder of joint of left ankle due to Behcet syndrome",
            "attributes": null
          },
          {
            "code": "15729041000119108",
            "description": "Disorder of joint of right ankle due to Behcet syndrome",
            "attributes": null
          },
          {
            "code": "16024431000119108",
            "description": "Acute polyarticular juvenile idiopathic arthritis",
            "attributes": null
          },
          {
            "code": "16044751000119106",
            "description": "Polyarticular juvenile idiopathic arthritis",
            "attributes": null
          },
          {
            "code": "16051551000119103",
            "description": "Disorder of joint of left knee due to Behcet syndrome",
            "attributes": null
          },
          {
            "code": "16051591000119108",
            "description": "Disorder of joint of right knee due to Behcet syndrome",
            "attributes": null
          },
          {
            "code": "165839004",
            "description": "Rheumatoid factor detected",
            "attributes": null
          },
          {
            "code": "170845006",
            "description": "Rheumatology disorder monitoring (& arthritis [& rheumatoid])",
            "attributes": null
          },
          {
            "code": "170848008",
            "description": "Rheumatology disorder - joints affected",
            "attributes": null
          },
          {
            "code": "170849000",
            "description": "Rheumatology symptom change",
            "attributes": null
          },
          {
            "code": "170850000",
            "description": "Rheumatology drug side effect",
            "attributes": null
          },
          {
            "code": "170851001",
            "description": "Rheumatology disorder treatment changed",
            "attributes": null
          },
          {
            "code": "170853003",
            "description": "Rheumatology disorder treatment started",
            "attributes": null
          },
          {
            "code": "170854009",
            "description": "Rheumatology disorder treatment stopped",
            "attributes": null
          },
          {
            "code": "187230004",
            "description": "Pulmonary sarcoidosis",
            "attributes": null
          },
          {
            "code": "187233002",
            "description": "Sarcoidosis of lung with sarcoidosis of lymph nodes",
            "attributes": null
          },
          {
            "code": "187235009",
            "description": "Sarcoidosis of inferior turbinates",
            "attributes": null
          },
          {
            "code": "190815001",
            "description": "Cryoglobulinemic vasculitis",
            "attributes": null
          },
          {
            "code": "191033003",
            "description": "[X]Sarcoidosis of other and combined sites",
            "attributes": null
          },
          {
            "code": "192673008",
            "description": "Sarcoid meningitis",
            "attributes": null
          },
          {
            "code": "193101001",
            "description": "Multiple cranial nerve palsies in sarcoidosis",
            "attributes": null
          },
          {
            "code": "193177003",
            "description": "Polyneuropathy in collagen vascular disease",
            "attributes": null
          },
          {
            "code": "193178008",
            "description": "Polyneuropathy in disseminated lupus erythematosus",
            "attributes": null
          },
          {
            "code": "193179000",
            "description": "Polyneuropathy in polyarteritis nodosa",
            "attributes": null
          },
          {
            "code": "193181003",
            "description": "Polyneuropathy in collagen vascular disease NOS",
            "attributes": null
          },
          {
            "code": "193195000",
            "description": "Sarcoid neuropathy",
            "attributes": null
          },
          {
            "code": "193248005",
            "description": "Myopathy due to disseminated lupus erythematosus",
            "attributes": null
          },
          {
            "code": "193249002",
            "description": "Myopathy due to polyarteritis nodosa",
            "attributes": null
          },
          {
            "code": "193251003",
            "description": "Sarcoid myopathy",
            "attributes": null
          },
          {
            "code": "193252005",
            "description": "Myopathy due to scleroderma",
            "attributes": null
          },
          {
            "code": "193253000",
            "description": "Myopathy due to Sjögren's disease",
            "attributes": null
          },
          {
            "code": "193776001",
            "description": "Keratoconjunctivitis sicca (excluding Sjögren syndrome)",
            "attributes": null
          },
          {
            "code": "195033009",
            "description": "Sarcoid heart muscle disease",
            "attributes": null
          },
          {
            "code": "195135000",
            "description": "Sarcoid myocarditis",
            "attributes": null
          },
          {
            "code": "19514005",
            "description": "Arthritis mutilans",
            "attributes": null
          },
          {
            "code": "195346008",
            "description": "Polyarteritis nodosa and allied conditions",
            "attributes": null
          },
          {
            "code": "195347004",
            "description": "(Polyarteritis nodosa) or (necrotising angiitis)",
            "attributes": null
          },
          {
            "code": "195351002",
            "description": "Goodpasture's syndrome",
            "attributes": null
          },
          {
            "code": "195352009",
            "description": "Hypersensitivity angiitis NOS",
            "attributes": null
          },
          {
            "code": "195353004",
            "description": "Granulomatosis with polyangiitis",
            "attributes": null
          },
          {
            "code": "195354005",
            "description": "Giant cell arteritis",
            "attributes": null
          },
          {
            "code": "195355006",
            "description": "Giant cell arteritis",
            "attributes": null
          },
          {
            "code": "195356007",
            "description": "Giant cell arteritis",
            "attributes": null
          },
          {
            "code": "195357003",
            "description": "Giant cell arteritis NOS",
            "attributes": null
          },
          {
            "code": "195361009",
            "description": "(Aortic arch arteritis) or (Takayasu's disease[& pulseless])",
            "attributes": null
          },
          {
            "code": "195362002",
            "description": "Churg-Strauss vasculitis",
            "attributes": null
          },
          {
            "code": "195363007",
            "description": "Juvenile polyarteritis",
            "attributes": null
          },
          {
            "code": "195365000",
            "description": "Polyarteritis nodosa and allied conditions NOS",
            "attributes": null
          },
          {
            "code": "195368003",
            "description": "(Arteritis unspecified) or (aortitis)",
            "attributes": null
          },
          {
            "code": "195375002",
            "description": "Vasculitis",
            "attributes": null
          },
          {
            "code": "196133001",
            "description": "Lung disease with systemic sclerosis",
            "attributes": null
          },
          {
            "code": "196136009",
            "description": "Lung disease co-occurrent with polymyositis",
            "attributes": null
          },
          {
            "code": "196137000",
            "description": "Lung disease with Sjögren's disease",
            "attributes": null
          },
          {
            "code": "196138005",
            "description": "Lung disease with systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "197368002",
            "description": "Hepatic granulomas in sarcoidosis",
            "attributes": null
          },
          {
            "code": "197607004",
            "description": "Nephrotic syndrome in polyarteritis nodosa",
            "attributes": null
          },
          {
            "code": "200936003",
            "description": "Lupus erythematosus",
            "attributes": null
          },
          {
            "code": "200938002",
            "description": "Discoid lupus erythematosus",
            "attributes": null
          },
          {
            "code": "200956002",
            "description": "Psoriatic arthritis with spine involvement",
            "attributes": null
          },
          {
            "code": "201435004",
            "description": "Systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "201436003",
            "description": "Drug-induced systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "201438002",
            "description": "Systemic lupus erythematosus with pericarditis",
            "attributes": null
          },
          {
            "code": "201439005",
            "description": "Systemic lupus erythematosus NOS",
            "attributes": null
          },
          {
            "code": "201440007",
            "description": "Scleroderma (& [acrosclerosis] or [systemic sclerosis])",
            "attributes": null
          },
          {
            "code": "201441006",
            "description": "Scleroderma",
            "attributes": null
          },
          {
            "code": "201444003",
            "description": "(Sicca - Sjogren's - syndrome) or (keratoconjunctivitis sicca)",
            "attributes": null
          },
          {
            "code": "201449008",
            "description": "Adult onset Still's disease",
            "attributes": null
          },
          {
            "code": "201484007",
            "description": "Arthropathy in Behcet's syndrome (& [unspecified site])",
            "attributes": null
          },
          {
            "code": "201485008",
            "description": "Arthropathy in Behcet's syndrome of the shoulder region",
            "attributes": null
          },
          {
            "code": "201486009",
            "description": "Arthropathy in Behcet's syndrome of the upper arm",
            "attributes": null
          },
          {
            "code": "201487000",
            "description": "Arthropathy in Behcet's syndrome of the forearm",
            "attributes": null
          },
          {
            "code": "201488005",
            "description": "Arthropathy in Behcet's syndrome of the hand",
            "attributes": null
          },
          {
            "code": "201489002",
            "description": "Arthropathy in Behcet's syndrome of the pelvic region and thigh",
            "attributes": null
          },
          {
            "code": "201490006",
            "description": "Arthropathy in Behcet's syndrome of the lower leg",
            "attributes": null
          },
          {
            "code": "201491005",
            "description": "Arthropathy in Behcet's syndrome of the ankle and/or foot",
            "attributes": null
          },
          {
            "code": "201492003",
            "description": "Arthropathy in Behcet's syndrome of multiple sites",
            "attributes": null
          },
          {
            "code": "201493008",
            "description": "Arthropathy in Behcet's syndrome of other specified sites",
            "attributes": null
          },
          {
            "code": "201494002",
            "description": "Arthropathy in Behcet's syndrome NOS",
            "attributes": null
          },
          {
            "code": "201763001",
            "description": "Inflammatory polyarthropathy: (& [rheumatoid arthritis] or [other])",
            "attributes": null
          },
          {
            "code": "201796004",
            "description": "Systemic onset juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "201801009",
            "description": "Other juvenile arthritis",
            "attributes": null
          },
          {
            "code": "201803007",
            "description": "Polyarticular onset juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "201804001",
            "description": "Juvenile psoriatic arthritis with psoriasis",
            "attributes": null
          },
          {
            "code": "201805000",
            "description": "Juvenile arthritis in Crohn's disease",
            "attributes": null
          },
          {
            "code": "201807008",
            "description": "Juvenile arthritis in ulcerative colitis",
            "attributes": null
          },
          {
            "code": "201809006",
            "description": "Pauciarticular onset juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "201815006",
            "description": "Adult onset Still's disease",
            "attributes": null
          },
          {
            "code": "202649003",
            "description": "Inflammatory spondylopathy",
            "attributes": null
          },
          {
            "code": "202652006",
            "description": "Inflammatory spondylopathy associated with another disorder",
            "attributes": null
          },
          {
            "code": "202834009",
            "description": "Polymyalgia (& [rheumatica])",
            "attributes": null
          },
          {
            "code": "203042003",
            "description": "Myositis in sarcoidosis",
            "attributes": null
          },
          {
            "code": "203735008",
            "description": "[X]Other juvenile arthritis",
            "attributes": null
          },
          {
            "code": "203736009",
            "description": "[X]Juvenile arthritis in other diseases classified elsewhere",
            "attributes": null
          },
          {
            "code": "203780009",
            "description": "[X]Systemic connective tissue disorders",
            "attributes": null
          },
          {
            "code": "203782001",
            "description": "[X]Other giant cell arteritis",
            "attributes": null
          },
          {
            "code": "203784000",
            "description": "[X]Other forms of systemic lupus erythematosus",
            "attributes": null
          },
          {
            "code": "203786003",
            "description": "[X]Other forms of systemic sclerosis",
            "attributes": null
          },
          {
            "code": "203787007",
            "description": "[X]Other overlap syndromes",
            "attributes": null
          },
          {
            "code": "203788002",
            "description": "[X]Other systemic diseases of connective tissue",
            "attributes": null
          },
          {
            "code": "236502006",
            "description": "Renal involvement in scleroderma",
            "attributes": null
          },
          {
            "code": "236503001",
            "description": "Acute scleroderma renal crisis",
            "attributes": null
          },
          {
            "code": "236506009",
            "description": "Goodpasture's disease",
            "attributes": null
          },
          {
            "code": "23685000",
            "description": "Rheumatic heart disease",
            "attributes": null
          },
          {
            "code": "23782005",
            "description": "Wegener's granulomatosis",
            "attributes": null
          },
          {
            "code": "239796000",
            "description": "Juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "239797009",
            "description": "Early onset pauciarticular chronic arthritis",
            "attributes": null
          },
          {
            "code": "239798004",
            "description": "Late onset pauciarticular chronic arthritis",
            "attributes": null
          },
          {
            "code": "239799007",
            "description": "Early onset polyarticular juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "239800006",
            "description": "Late onset polyarticular juvenile chronic arthritis",
            "attributes": null
          },
          {
            "code": "239802003",
            "description": "Juvenile psoriatic arthritis",
            "attributes": null
          },
          {
            "code": "239803008",
            "description": "Juvenile psoriatic arthritis with psoriasis",
            "attributes": null
          },
          {
            "code": "239804002",
            "description": "Juvenile psoriatic arthritis without psoriasis",
            "attributes": null
          },
          {
            "code": "239805001",
            "description": "Juvenile ankylosing spondylitis",
            "attributes": null
          },
          {
            "code": "239806000",
            "description": "Juvenile spondyloarthropathy",
            "attributes": null
          },
          {
            "code": "239809007",
            "description": "Juvenile arthritis of inflammatory bowel disease",
            "attributes": null
          },
          {
            "code": "239812005",
            "description": "Psoriatic arthritis with distal interphalangeal joint involvement",
            "attributes": null
          },
          {
            "code": "239813000",
            "description": "Psoriatic dactylitis",
            "attributes": null
          },
          {
            "code": "239887007",
            "description": "Systemic lupus erythematosus with organ/system involvement",
            "attributes": null
          },
          {
            "code": "239891002",
            "description": "Subacute cutaneous lupus erythematosus",
            "attributes": null
          },
          {
            "code": "239912009",
            "description": "Primary Sjögren's syndrome",
            "attributes": null
          },
          {
            "code": "239915006",
            "description": "Secondary Sjögren's syndrome",
            "attributes": null
          },
          {
            "code": "239920006",
            "description": "Adult onset Still's disease",
            "attributes": null
          },
          {
            "code": "239933000",
            "description": "Primary necrotizing vasculitis with granulomata",
            "attributes": null
          },
          {
            "code": "239938009",
            "description": "Giant cell arteritis with polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "24369008",
            "description": "Pulmonary sarcoidosis",
            "attributes": null
          },
          {
            "code": "24693007",
            "description": "Fibromyositis",
            "attributes": null
          },
          {
            "code": "266265002",
            "description": "Arteritis unspecified",
            "attributes": null
          },
          {
            "code": "266323005",
            "description": "(Goodpasture's syndrome) or (Wegener's granulomatosis) or (Takayasu's disease) or (polyarteritis nodosa NOS)",
            "attributes": null
          },
          {
            "code": "267874003",
            "description": "Scleroderma",
            "attributes": null
          },
          {
            "code": "267884002",
            "description": "Arthropathy in Behcet's syndrome of unspecified site",
            "attributes": null
          },
          {
            "code": "267988003",
            "description": "Polymyalgia rheumatica",
            "attributes": null
          },
          {
            "code": "268049000",
            "description": "Scleroderma (& [systemic sclerosis])",
            "attributes": null
          },
          {
            "code": "268524007",
            "description": "Rheumatology disorder monitoring",
            "attributes": null
          },
          {
            "code": "26889001",
            "description": "Myositis",
            "attributes": null
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