[
  {
    "phenotype_id": "PH2678",
    "phenotype_version_id": 6660,
    "name": "Hypopituitary disorder codes",
    "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\nTaken from the `HYPOPITUITARY_COD` refset published by NHSD. Contains public sector information licensed under the UK Open Government Licence v3\\.0 (https://www.nationalarchives.gov.uk/doc/open\\-government\\-licence/version/3/).\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n",
    "implementation": null,
    "publications": null,
    "validation": null,
    "citation_requirements": null,
    "created": "2026-01-26T22:35:52.907042Z",
    "author": "NHSD Primary Care Domain Refsets",
    "collections": [
      {
        "name": "OpenCodelist",
        "value": 31
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 1,
      "slug": "opensafely",
      "name": "OpenSAFELY"
    },
    "world_access": 1,
    "updated": "2026-01-26T22:35:57.077118Z",
    "references": [],
    "signed_off": [],
    "methodology": "",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      }
    ],
    "open_codelist_id": "nhsd-primary-care-domain-refsets/hypopituitary_cod",
    "source_reference": "https://www.opencodelists.org/codelist/nhsd-primary-care-domain-refsets/hypopituitary_cod/20250912",
    "concept_information": [
      {
        "concept_id": 6837,
        "concept_version_id": 14322,
        "concept_name": "nhsd-primary-care-domain-refsets/hypopituitary_cod/20250912",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH2678",
        "phenotype_version_id": 6660,
        "phenotype_name": "Hypopituitary disorder codes",
        "code_attribute_header": [],
        "codes": [
          {
            "code": "1003380001",
            "description": "6q16 microdeletion syndrome",
            "attributes": null
          },
          {
            "code": "1179382007",
            "description": "Acquired central hypothyroidism due to disorder of pituitary gland",
            "attributes": null
          },
          {
            "code": "1186807002",
            "description": "Hereditary growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "1186833005",
            "description": "Hypopituitarism due to disorder of blood vessel",
            "attributes": null
          },
          {
            "code": "1186835003",
            "description": "Hypopituitarism due to disorder characterized by granuloma",
            "attributes": null
          },
          {
            "code": "1186837006",
            "description": "Hypopituitarism due to metabolic disease",
            "attributes": null
          },
          {
            "code": "1186855002",
            "description": "Autoimmune hypopituitarism",
            "attributes": null
          },
          {
            "code": "1187531009",
            "description": "Obesity due to pituitary disease",
            "attributes": null
          },
          {
            "code": "1217046003",
            "description": "Avascular necrosis of pituitary gland",
            "attributes": null
          },
          {
            "code": "1217051009",
            "description": "Isolated deficiency of pituitary hormone",
            "attributes": null
          },
          {
            "code": "1231283007",
            "description": "Congenital isolated adrenocorticotropic hormone deficiency",
            "attributes": null
          },
          {
            "code": "123760002",
            "description": "Prepuberal panhypopituitarism",
            "attributes": null
          },
          {
            "code": "129633006",
            "description": "Induced female hypogonadism syndrome",
            "attributes": null
          },
          {
            "code": "14289006",
            "description": "Myopathy in hypopituitarism",
            "attributes": null
          },
          {
            "code": "14900002",
            "description": "Hypopituitarism due to radiotherapy",
            "attributes": null
          },
          {
            "code": "15045007",
            "description": "Ischemic postpartum pituitary necrosis",
            "attributes": null
          },
          {
            "code": "154700009",
            "description": "Hypopituit (& [panhypopituitarism])",
            "attributes": null
          },
          {
            "code": "154701008",
            "description": "Pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "154702001",
            "description": "Growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "17151000119108",
            "description": "Partial growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "18200000",
            "description": "Autosomal recessive isolated somatotropin deficiency",
            "attributes": null
          },
          {
            "code": "190469009",
            "description": "Hypopituitarism: [NOS] or [Sheehan's syndrome] or [Simmond's disease] or [Panhypopituitarism]",
            "attributes": null
          },
          {
            "code": "190470005",
            "description": "Idiopathic panhypopituitarism",
            "attributes": null
          },
          {
            "code": "190471009",
            "description": "Post-birth injury panhypopituitarism",
            "attributes": null
          },
          {
            "code": "190472002",
            "description": "Post-infarction panhypopituitarism",
            "attributes": null
          },
          {
            "code": "190473007",
            "description": "Post-infective hypopituitarism",
            "attributes": null
          },
          {
            "code": "190474001",
            "description": "Other specified panhypopituitarism",
            "attributes": null
          },
          {
            "code": "190475000",
            "description": "Panhypopituitarism NOS",
            "attributes": null
          },
          {
            "code": "190477008",
            "description": "Other specified pituitary dwarfism (& [ateliotic dwarf])",
            "attributes": null
          },
          {
            "code": "190478003",
            "description": "Pituitary dwarfism NOS",
            "attributes": null
          },
          {
            "code": "205749001",
            "description": "Congenital absence of pituitary gland",
            "attributes": null
          },
          {
            "code": "2109003",
            "description": "Isolated somatotropin deficiency",
            "attributes": null
          },
          {
            "code": "230240004",
            "description": "Progressive cerebellar ataxia with hypogonadism",
            "attributes": null
          },
          {
            "code": "230795009",
            "description": "Pituitary coma",
            "attributes": null
          },
          {
            "code": "234533006",
            "description": "X-linked agammaglobulinemia with growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "237681002",
            "description": "Hypopituitarism NOS",
            "attributes": null
          },
          {
            "code": "237682009",
            "description": "Panhypopituitarism - anterior and posterior",
            "attributes": null
          },
          {
            "code": "237683004",
            "description": "X-linked panhypopituitarism",
            "attributes": null
          },
          {
            "code": "237684005",
            "description": "Sheehan's syndrome",
            "attributes": null
          },
          {
            "code": "237685006",
            "description": "Partial hypopituitarism",
            "attributes": null
          },
          {
            "code": "237687003",
            "description": "Isolated growth hormone deficiency - autosomal dominant",
            "attributes": null
          },
          {
            "code": "237688008",
            "description": "Idiopathic growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "237689000",
            "description": "Growth hormone neurosecretory dysfunction",
            "attributes": null
          },
          {
            "code": "237691008",
            "description": "Psychosocial growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "237692001",
            "description": "Adrenocorticotropic hormone deficiency",
            "attributes": null
          },
          {
            "code": "237693006",
            "description": "Idiopathic adrenocorticotropic hormone deficiency",
            "attributes": null
          },
          {
            "code": "237694000",
            "description": "Steroid suppression of adrenocorticotropic hormone secretion",
            "attributes": null
          },
          {
            "code": "237695004",
            "description": "Idiopathic thyroid stimulating hormone deficiency",
            "attributes": null
          },
          {
            "code": "237697007",
            "description": "Oxytocin deficiency",
            "attributes": null
          },
          {
            "code": "237698002",
            "description": "Iatrogenic hypopituitarism",
            "attributes": null
          },
          {
            "code": "237699005",
            "description": "Post-traumatic hypopituitarism",
            "attributes": null
          },
          {
            "code": "237700006",
            "description": "Hypopituitarism due to iron overload",
            "attributes": null
          },
          {
            "code": "237707009",
            "description": "Lymphocytic hypophysitis of pregnancy",
            "attributes": null
          },
          {
            "code": "237732006",
            "description": "Anterior pituitary hormone deficiency NEC",
            "attributes": null
          },
          {
            "code": "267388009",
            "description": "Idiopathic hypopituitarism",
            "attributes": null
          },
          {
            "code": "267389001",
            "description": "Post-birth injury hypopituitarism",
            "attributes": null
          },
          {
            "code": "267390005",
            "description": "Post-infarction hypopituitarism",
            "attributes": null
          },
          {
            "code": "267391009",
            "description": "Other specified pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "267481002",
            "description": "Hypopituit (& [panhypopituitarism])",
            "attributes": null
          },
          {
            "code": "270485009",
            "description": "Pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "271386001",
            "description": "Post-infective hypopituitarism",
            "attributes": null
          },
          {
            "code": "27270004",
            "description": "Pituitary dwarfism with large sella turcica",
            "attributes": null
          },
          {
            "code": "2851000119101",
            "description": "Anterior pituitary hormone deficiency",
            "attributes": null
          },
          {
            "code": "290653008",
            "description": "Postpartum hypopituitarism",
            "attributes": null
          },
          {
            "code": "291665000",
            "description": "Postpartum intrapituitary hemorrhage",
            "attributes": null
          },
          {
            "code": "302867007",
            "description": "Growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "3072001",
            "description": "Hormone-induced hypopituitarism",
            "attributes": null
          },
          {
            "code": "32390006",
            "description": "Panhypopituitarism",
            "attributes": null
          },
          {
            "code": "33927004",
            "description": "Hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "361117008",
            "description": "Female hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "367161000119106",
            "description": "Tertiary hypothyroidism",
            "attributes": null
          },
          {
            "code": "367411000119102",
            "description": "Hypopituitarism caused by drug",
            "attributes": null
          },
          {
            "code": "367460001",
            "description": "Pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "37355009",
            "description": "Royer's syndrome",
            "attributes": null
          },
          {
            "code": "38196001",
            "description": "Laron-type isolated somatotropin defect",
            "attributes": null
          },
          {
            "code": "38576000",
            "description": "Nonfamilial hyperinsulinemic isolated somatotropin deficiency",
            "attributes": null
          },
          {
            "code": "39591000119109",
            "description": "Female infertility due to disorder of pituitary gland",
            "attributes": null
          },
          {
            "code": "397827003",
            "description": "Growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "40781006",
            "description": "Hypopituitarism due to pituitary neoplasm",
            "attributes": null
          },
          {
            "code": "420351005",
            "description": "Adult-onset growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "420499009",
            "description": "Hypogonadotropic hypogonadism due to isolated gonadotropin deficiency",
            "attributes": null
          },
          {
            "code": "421019006",
            "description": "Hypogonadotropic hypogonadism due to follicle-stimulating hormone deficiency",
            "attributes": null
          },
          {
            "code": "421684006",
            "description": "Adult growth hormone deficiency",
            "attributes": null
          },
          {
            "code": "421821002",
            "description": "Hypogonadotropic hypogonadism due to luteinizing hormone deficiency",
            "attributes": null
          },
          {
            "code": "421931005",
            "description": "Adult growth hormone deficiency with onset in childhood",
            "attributes": null
          },
          {
            "code": "429514007",
            "description": "Growth hormone deficiency after bone marrow transplant",
            "attributes": null
          },
          {
            "code": "44008002",
            "description": "Somatotropin deficiency",
            "attributes": null
          },
          {
            "code": "442001",
            "description": "Secondary hypopituitarism",
            "attributes": null
          },
          {
            "code": "45617007",
            "description": "Pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "510111000000104",
            "description": "Hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "55267000",
            "description": "Pituitary hypothyroidism",
            "attributes": null
          },
          {
            "code": "59572000",
            "description": "Necrosis of pituitary",
            "attributes": null
          },
          {
            "code": "60138009",
            "description": "Anemia of pituitary deficiency",
            "attributes": null
          },
          {
            "code": "61701006",
            "description": "Lymphocytic hypopituitarism",
            "attributes": null
          },
          {
            "code": "62999006",
            "description": "Adiposogenital dystrophy",
            "attributes": null
          },
          {
            "code": "638241000000108",
            "description": "Pituitary dwarfism NOS",
            "attributes": null
          },
          {
            "code": "642701000000104",
            "description": "Other specified panhypopituitarism",
            "attributes": null
          },
          {
            "code": "642711000000102",
            "description": "Panhypopituitarism NOS",
            "attributes": null
          },
          {
            "code": "672631000000101",
            "description": "Hypopituitarism NOS",
            "attributes": null
          },
          {
            "code": "67873006",
            "description": "Isolated prolactin deficiency",
            "attributes": null
          },
          {
            "code": "679601000000102",
            "description": "Other specified pituitary dwarfism",
            "attributes": null
          },
          {
            "code": "685481000000100",
            "description": "Anterior pituitary hormone deficiency NEC",
            "attributes": null
          },
          {
            "code": "702949005",
            "description": "Proopiomelanocortin deficiency syndrome",
            "attributes": null
          },
          {
            "code": "71003000",
            "description": "Ateleiotic dwarfism",
            "attributes": null
          },
          {
            "code": "715417002",
            "description": "Choroideremia co-occurrent with hypopituitarism",
            "attributes": null
          },
          {
            "code": "715668008",
            "description": "Pituitary deficiency due to empty sella turcica syndrome",
            "attributes": null
          },
          {
            "code": "715727009",
            "description": "Pituitary stalk interruption syndrome",
            "attributes": null
          },
          {
            "code": "715984007",
            "description": "Cerebellar ataxia with hypogonadism and choroidal dystrophy syndrome",
            "attributes": null
          },
          {
            "code": "718182008",
            "description": "Combined pituitary hormone deficiency genetic form",
            "attributes": null
          },
          {
            "code": "718194004",
            "description": "Hypothyroidism due to mutation in transcription factor of pituitary development",
            "attributes": null
          },
          {
            "code": "719809005",
            "description": "X-linked intellectual disability with precocious puberty and obesity syndrome",
            "attributes": null
          },
          {
            "code": "721072003",
            "description": "Short stature, pituitary and cerebellar defect and small sella turcica syndrome",
            "attributes": null
          },
          {
            "code": "721288009",
            "description": "Hypopituitarism following procedure",
            "attributes": null
          },
          {
            "code": "721842008",
            "description": "Hypogonadotropic hypogonadism with frontoparietal alopecia syndrome",
            "attributes": null
          },
          {
            "code": "721846006",
            "description": "Hypomyelination, hypogonadotropic hypogonadism, hypodontia syndrome",
            "attributes": null
          },
          {
            "code": "722380003",
            "description": "Congenital cataract with intellectual disability and hypogonadotropic hypogonadism syndrome",
            "attributes": null
          },
          {
            "code": "722944006",
            "description": "Congenital hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "723999009",
            "description": "Retinitis pigmentosa, hypopituitarism, nephronophthisis, skeletal dysplasia syndrome",
            "attributes": null
          },
          {
            "code": "724174003",
            "description": "Moebius syndrome, axonal neuropathy, hypogonadotropic hypogonadism syndrome",
            "attributes": null
          },
          {
            "code": "724281002",
            "description": "Hyposmia, nasal and ocular hypoplasia, hypogonadotropic hypogonadism syndrome",
            "attributes": null
          },
          {
            "code": "724385009",
            "description": "Growth delay due to insulin-like growth factor type 1 deficiency",
            "attributes": null
          },
          {
            "code": "733113002",
            "description": "Hypogonadotropic hypogonadism retinitis pigmentosa syndrome",
            "attributes": null
          },
          {
            "code": "74501005",
            "description": "Female hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "74728003",
            "description": "Hypopituitarism",
            "attributes": null
          },
          {
            "code": "7530009",
            "description": "Asexual dwarfism",
            "attributes": null
          },
          {
            "code": "7611002",
            "description": "Septo-optic dysplasia sequence",
            "attributes": null
          },
          {
            "code": "763866005",
            "description": "Postaxial polydactyly, anterior pituitary anomalies, facial dysmorphism syndrome",
            "attributes": null
          },
          {
            "code": "764959000",
            "description": "Intellectual disability, myopathy, short stature, endocrine defect syndrome",
            "attributes": null
          },
          {
            "code": "770680004",
            "description": "Prader-Willi-like syndrome",
            "attributes": null
          },
          {
            "code": "770941005",
            "description": "Alopecia, progressive neurological defect, endocrinopathy syndrome",
            "attributes": null
          },
          {
            "code": "771308008",
            "description": "Non-acquired combined pituitary hormone deficiency, sensorineural hearing loss, spine abnormalities syndrome",
            "attributes": null
          },
          {
            "code": "773664005",
            "description": "Deficiency in anterior pituitary function, variable immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "773665006",
            "description": "Hypogonadotropic hypogonadism, severe microcephaly, sensorineural hearing loss, dysmorphism syndrome",
            "attributes": null
          },
          {
            "code": "773989002",
            "description": "Late-onset isolated adrenocorticotropic hormone deficiency",
            "attributes": null
          },
          {
            "code": "782917007",
            "description": "Familial adrenal hypoplasia with absent pituitary luteinizing hormone",
            "attributes": null
          },
          {
            "code": "783008000",
            "description": "Pituitary dermoid and epidermoid cysts",
            "attributes": null
          },
          {
            "code": "783009008",
            "description": "Pituitary deficiency due to Rathke cleft cysts",
            "attributes": null
          },
          {
            "code": "783243008",
            "description": "Adenohypophysitis",
            "attributes": null
          },
          {
            "code": "785722006",
            "description": "Obesity due to leptin receptor gene deficiency",
            "attributes": null
          },
          {
            "code": "7990002",
            "description": "Immunoglobulinemia with isolated somatotropin deficiency",
            "attributes": null
          },
          {
            "code": "80599001",
            "description": "Isolated corticotropin deficiency",
            "attributes": null
          },
          {
            "code": "82598004",
            "description": "Secondary hypothyroidism",
            "attributes": null
          },
          {
            "code": "846680003",
            "description": "Functional hypogonadotropic hypogonadism",
            "attributes": null
          },
          {
            "code": "89261000",
            "description": "Isolated thyrotropin deficiency",
            "attributes": null
          },
          {
            "code": "89392001",
            "description": "Prader-Willi syndrome",
            "attributes": null
          },
          {
            "code": "89476005",
            "description": "Pituitary cachexia",
            "attributes": null
          },
          {
            "code": "90182005",
            "description": "Hypophysectomy-induced hypopituitarism",
            "attributes": null
          },
          {
            "code": "91187007",
            "description": "Pituitary dwarfism with small sella turcica",
            "attributes": null
          },
          {
            "code": "93559003",
            "description": "Hypogonadism with anosmia",
            "attributes": null
          }
        ]
      }
    ],
    "coding_system_release": "",
    "open_codelist_version_id": "5f8ee780",
    "open_codelist_version_tag": "20250912",
    "status": 1,
    "doi": "https://doi.org/10.48533/jrn6-w546",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 3,
      "name": "OpenCodelists Phenotype",
      "description": "OpenSafely's OpenCodelist Phenotype, visit https://www.opencodelists.org/ to learn more",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 6660,
        "version_name": "Hypopituitary disorder codes",
        "version_date": "2026-01-26T22:35:57.088776Z",
        "is_published": true,
        "is_latest": true
      },
      {
        "version_id": 6659,
        "version_name": "Hypopituitary disorder codes",
        "version_date": "2026-01-26T22:35:55.598837Z",
        "is_published": true,
        "is_latest": false
      },
      {
        "version_id": 6658,
        "version_name": "Hypopituitary disorder codes",
        "version_date": "2026-01-26T22:35:52.918958Z",
        "is_published": true,
        "is_latest": false
      }
    ]
  }
]