[
  {
    "phenotype_id": "PH2748",
    "phenotype_version_id": 6903,
    "name": "Lymphoproliferative disorders",
    "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\nTaken from the `LYMPHOPROLDIS_COD` refset published by NHSD. Contains public sector information licensed under the UK Open Government Licence v3\\.0 (https://www.nationalarchives.gov.uk/doc/open\\-government\\-licence/version/3/).\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n",
    "implementation": null,
    "publications": null,
    "validation": null,
    "citation_requirements": null,
    "created": "2026-01-26T22:41:21.101528Z",
    "author": "NHSD Primary Care Domain Refsets",
    "collections": [
      {
        "name": "OpenCodelist",
        "value": 31
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 1,
      "slug": "opensafely",
      "name": "OpenSAFELY"
    },
    "world_access": 1,
    "updated": "2026-01-26T22:41:23.691920Z",
    "references": [],
    "signed_off": [],
    "methodology": "",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      }
    ],
    "open_codelist_id": "nhsd-primary-care-domain-refsets/lymphoproldis_cod",
    "source_reference": "https://www.opencodelists.org/codelist/nhsd-primary-care-domain-refsets/lymphoproldis_cod/20250912",
    "concept_information": [
      {
        "concept_id": 7080,
        "concept_version_id": 14565,
        "concept_name": "nhsd-primary-care-domain-refsets/lymphoproldis_cod/20250912",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH2748",
        "phenotype_version_id": 6903,
        "phenotype_name": "Lymphoproliferative disorders",
        "code_attribute_header": [],
        "codes": [
          {
            "code": "109980005",
            "description": "Malignant immunoproliferative disease",
            "attributes": null
          },
          {
            "code": "109982002",
            "description": "Alpha heavy chain disease",
            "attributes": null
          },
          {
            "code": "109984001",
            "description": "Gamma heavy chain disease",
            "attributes": null
          },
          {
            "code": "109985000",
            "description": "Immunoproliferative small intestinal disease",
            "attributes": null
          },
          {
            "code": "1144957009",
            "description": "Vasculitis due to lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "1156784009",
            "description": "Localized Castleman disease",
            "attributes": null
          },
          {
            "code": "1156805003",
            "description": "Multicentric Castleman disease",
            "attributes": null
          },
          {
            "code": "1162828001",
            "description": "X-linked lymphoproliferative disease due to SH2D1A deficiency",
            "attributes": null
          },
          {
            "code": "1162830004",
            "description": "X-linked lymphoproliferative disease due to XIAP deficiency",
            "attributes": null
          },
          {
            "code": "1197361002",
            "description": "Autoimmune lymphoproliferative syndrome due to cytotoxic T-lymphocyte associated protein 4 haploinsufficiency",
            "attributes": null
          },
          {
            "code": "1197362009",
            "description": "Signal transducer and activator of transcription 3-related early-onset multisystem autoimmune disease",
            "attributes": null
          },
          {
            "code": "122491000119108",
            "description": "Lymphoproliferative disorder after transplantation of bone marrow",
            "attributes": null
          },
          {
            "code": "123313007",
            "description": "Alpha heavy chain disease, enteric form",
            "attributes": null
          },
          {
            "code": "125574005",
            "description": "Angiolymphoid hyperplasia with eosinophilia",
            "attributes": null
          },
          {
            "code": "1259049004",
            "description": "Castleman disease with immunoglobulin M monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "127071007",
            "description": "Immunoproliferative disorder",
            "attributes": null
          },
          {
            "code": "127213008",
            "description": "Angiofollicular lymph node hyperplasia, hyaline-vascular type",
            "attributes": null
          },
          {
            "code": "127214002",
            "description": "Angiofollicular lymph node hyperplasia, plasma cell type",
            "attributes": null
          },
          {
            "code": "127215001",
            "description": "Progressively transformed germinal centers",
            "attributes": null
          },
          {
            "code": "127217009",
            "description": "Histiocytic necrotizing lymphadenitis",
            "attributes": null
          },
          {
            "code": "127219007",
            "description": "Post-transplantation lymphoproliferative syndrome",
            "attributes": null
          },
          {
            "code": "127901000119107",
            "description": "Light chain nephropathy due to plasma cell dyscrasia",
            "attributes": null
          },
          {
            "code": "128871009",
            "description": "Virus-associated atypical lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "128874001",
            "description": "Cutaneous CD30+ lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "148041000146104",
            "description": "Heavy chain deposition disease",
            "attributes": null
          },
          {
            "code": "190073000",
            "description": "Chronic lymphoproliferative disease",
            "attributes": null
          },
          {
            "code": "20224008",
            "description": "Delta heavy chain disease",
            "attributes": null
          },
          {
            "code": "20447006",
            "description": "Plasma cell dyscrasia with polyneuropathy",
            "attributes": null
          },
          {
            "code": "207036003",
            "description": "Castleman's disease",
            "attributes": null
          },
          {
            "code": "20991001",
            "description": "Atypical lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "239297008",
            "description": "Lymphomatoid granulomatosis of lung",
            "attributes": null
          },
          {
            "code": "239940004",
            "description": "Lymphomatoid granulomatosis",
            "attributes": null
          },
          {
            "code": "25050002",
            "description": "Alpha heavy chain disease, respiratory form",
            "attributes": null
          },
          {
            "code": "254290004",
            "description": "Lymphoproliferative disorder following transplantation",
            "attributes": null
          },
          {
            "code": "254636003",
            "description": "Lymphomatoid granulomatosis of lung",
            "attributes": null
          },
          {
            "code": "275524009",
            "description": "Immunoproliferative neoplasm",
            "attributes": null
          },
          {
            "code": "277466009",
            "description": "Lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "277577000",
            "description": "Monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "277606000",
            "description": "Lymphoreticular tumor",
            "attributes": null
          },
          {
            "code": "285423008",
            "description": "Immunoglobulin A monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "285424002",
            "description": "Immunoglobulin G monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "285426000",
            "description": "Immunoglobulin M monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "285428004",
            "description": "Immunoglobulin D monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "285430002",
            "description": "Light chain monoclonal gammopathy of uncertain significance",
            "attributes": null
          },
          {
            "code": "31047003",
            "description": "Lymphomatoid papulosis",
            "attributes": null
          },
          {
            "code": "34287003",
            "description": "Rosai-Dorfman disease",
            "attributes": null
          },
          {
            "code": "399945005",
            "description": "Castleman's superficial pseudotumor, involving skin",
            "attributes": null
          },
          {
            "code": "400131007",
            "description": "Epithelioid hemangioma of skin",
            "attributes": null
          },
          {
            "code": "403217003",
            "description": "Subcorneal pustular dermatosis with paraproteinemia",
            "attributes": null
          },
          {
            "code": "404103007",
            "description": "Lymphomatoid papulosis type A (CD-30 positive type)",
            "attributes": null
          },
          {
            "code": "404104001",
            "description": "Lymphomatoid papulosis type B - mycosis fungoides-like",
            "attributes": null
          },
          {
            "code": "404105000",
            "description": "Lymphomatoid papulosis type C (anaplastic large-cell lymphoma-like)",
            "attributes": null
          },
          {
            "code": "404165002",
            "description": "Necrobiotic xanthogranuloma with paraproteinemia",
            "attributes": null
          },
          {
            "code": "414235005",
            "description": "Fatal infectious mononucleosis associated with X-linked lymphoproliferative syndrome",
            "attributes": null
          },
          {
            "code": "415111003",
            "description": "Plasma cell neoplasm",
            "attributes": null
          },
          {
            "code": "427374007",
            "description": "Immunoproliferative neoplasm in remission",
            "attributes": null
          },
          {
            "code": "44274007",
            "description": "Lymphoid interstitial pneumonitis",
            "attributes": null
          },
          {
            "code": "445964006",
            "description": "Monomorphic posttransplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "450943001",
            "description": "Post transplant lymphoproliferative disorder, no International Classification of Diseases for Oncology subtype",
            "attributes": null
          },
          {
            "code": "450944007",
            "description": "Polymorphic post transplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "60337005",
            "description": "Lymphomatoid granulomatosis",
            "attributes": null
          },
          {
            "code": "60620005",
            "description": "Epsilon heavy chain disease",
            "attributes": null
          },
          {
            "code": "61493004",
            "description": "Mu heavy chain disease",
            "attributes": null
          },
          {
            "code": "66184009",
            "description": "Hemolytic anemia associated with lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "68979007",
            "description": "Heavy chain disease",
            "attributes": null
          },
          {
            "code": "69484003",
            "description": "Angiofollicular lymph node hyperplasia",
            "attributes": null
          },
          {
            "code": "702444009",
            "description": "Autoimmune lymphoproliferative syndrome",
            "attributes": null
          },
          {
            "code": "703801008",
            "description": "Acquired angioedema due to lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "707901000000101",
            "description": "Post-transplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "71390001",
            "description": "Plasma cell dyscrasia",
            "attributes": null
          },
          {
            "code": "714460000",
            "description": "Castleman disease co-occurrent with infection caused by Human herpesvirus 8",
            "attributes": null
          },
          {
            "code": "717780007",
            "description": "Monoclonal B-cell lymphocytosis",
            "attributes": null
          },
          {
            "code": "721093000",
            "description": "Dianzani autoimmune lymphoproliferative disease",
            "attributes": null
          },
          {
            "code": "721311006",
            "description": "Systemic Epstein-Barr virus positive T-cell lymphoproliferative disease of childhood",
            "attributes": null
          },
          {
            "code": "722290008",
            "description": "Autoimmune lymphoproliferative syndrome with recurrent viral infection",
            "attributes": null
          },
          {
            "code": "722955006",
            "description": "Chronic lymphoproliferative disorder of natural killer cells",
            "attributes": null
          },
          {
            "code": "722956007",
            "description": "Early post-transplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "722957003",
            "description": "Reactive plasmacytic hyperplasia post-transplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "722958008",
            "description": "Infectious mononucleosis-like post-transplant lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "723496007",
            "description": "Natural killer cell enteropathy",
            "attributes": null
          },
          {
            "code": "723508002",
            "description": "RAS-associated autoimmune leukoproliferative disease",
            "attributes": null
          },
          {
            "code": "732963000",
            "description": "Secondary autoimmune hemolytic anemia co-occurrent and due to lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "762316003",
            "description": "Polymorphic lymphoproliferative disorder following transplant",
            "attributes": null
          },
          {
            "code": "763864008",
            "description": "Persistent polyclonal B-cell lymphocytosis",
            "attributes": null
          },
          {
            "code": "771073006",
            "description": "Lymphoproliferative disorder caused by methotrexate",
            "attributes": null
          },
          {
            "code": "77121009",
            "description": "X-linked lymphoproliferative syndrome",
            "attributes": null
          },
          {
            "code": "771309000",
            "description": "Autosomal recessive lymphoproliferative disease",
            "attributes": null
          },
          {
            "code": "783150002",
            "description": "Iatrogenic immunodeficiency-associated lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "783211008",
            "description": "Non-chronic lymphocytic leukemia monoclonal B-cell lymphocytosis",
            "attributes": null
          },
          {
            "code": "783565007",
            "description": "Indolent T-cell lymphoproliferative disorder of gastrointestinal tract",
            "attributes": null
          },
          {
            "code": "783566008",
            "description": "Mucocutaneous ulcer caused by Epstein-Barr virus",
            "attributes": null
          },
          {
            "code": "786855003",
            "description": "Monoclonal B-cell lymphocytosis chronic lymphocytic leukemia-type",
            "attributes": null
          },
          {
            "code": "787125004",
            "description": "Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8",
            "attributes": null
          },
          {
            "code": "788674000",
            "description": "Primary cutaneous CD4 positive small and medium T-cell lymphoproliferative disorder",
            "attributes": null
          },
          {
            "code": "789689004",
            "description": "Malignant lymphomatoid granulomatosis",
            "attributes": null
          },
          {
            "code": "789690008",
            "description": "Malignant lymphomatoid granulomatosis of lung",
            "attributes": null
          },
          {
            "code": "82546001",
            "description": "Reactive immunoproliferative disease",
            "attributes": null
          },
          {
            "code": "829971006",
            "description": "Non-amyloid monoclonal immunoglobulin deposition disease",
            "attributes": null
          },
          {
            "code": "84631004",
            "description": "Lymphoproliferative disease, no International Classification of Diseases for Oncology subtype",
            "attributes": null
          },
          {
            "code": "878857009",
            "description": "Malignant lymphomatoid granulomatosis grade 3",
            "attributes": null
          },
          {
            "code": "878858004",
            "description": "Malignant lymphomatoid granulomatosis grade 3 of lung",
            "attributes": null
          },
          {
            "code": "896745008",
            "description": "Primary cutaneous CD30 antigen positive T-cell lymphoproliferative disorder",
            "attributes": null
          }
        ]
      }
    ],
    "coding_system_release": "",
    "open_codelist_version_id": "60bda955",
    "open_codelist_version_tag": "20250912",
    "status": 1,
    "doi": "https://doi.org/10.48533/jpvx-g272",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
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      "name": "OpenCodelists Phenotype",
      "description": "OpenSafely's OpenCodelist Phenotype, visit https://www.opencodelists.org/ to learn more",
      "version_id": 1
    },
    "versions": [
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        "version_id": 6903,
        "version_name": "Lymphoproliferative disorders",
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]