[
  {
    "phenotype_id": "PH3005",
    "phenotype_version_id": 7738,
    "name": "Severely immunocompromised codes",
    "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\nTaken from the `SEVIMATRISK_COD` refset published by NHSD. Contains public sector information licensed under the UK Open Government Licence v3\\.0 (https://www.nationalarchives.gov.uk/doc/open\\-government\\-licence/version/3/).\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n",
    "implementation": null,
    "publications": null,
    "validation": null,
    "citation_requirements": null,
    "created": "2026-01-26T22:57:35.992904Z",
    "author": "NHSD Primary Care Domain Refsets",
    "collections": [
      {
        "name": "OpenCodelist",
        "value": 31
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 1,
      "slug": "opensafely",
      "name": "OpenSAFELY"
    },
    "world_access": 1,
    "updated": "2026-01-26T22:57:40.142939Z",
    "references": [
      {
        "url": "https://digital.nhs.uk/data-and-information/data-collections-and-data-sets/data-collections/quality-and-outcomes-framework-qof/quality-and-outcome-framework-qof-business-rules/primary-care-domain-reference-set-portal",
        "title": "Primary Care Domain Reference Set Portal"
      }
    ],
    "signed_off": [],
    "methodology": "",
    "coding_system": [
      {
        "name": "SNOMED  CT codes",
        "value": 9
      }
    ],
    "open_codelist_id": "nhsd-primary-care-domain-refsets/sevimatrisk_cod",
    "source_reference": "https://www.opencodelists.org/codelist/nhsd-primary-care-domain-refsets/sevimatrisk_cod/20250912",
    "concept_information": [
      {
        "concept_id": 7915,
        "concept_version_id": 15400,
        "concept_name": "nhsd-primary-care-domain-refsets/sevimatrisk_cod/20250912",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH3005",
        "phenotype_version_id": 7738,
        "phenotype_name": "Severely immunocompromised codes",
        "code_attribute_header": [],
        "codes": [
          {
            "code": "111587007",
            "description": "Severe combined immunodeficiency due to absent interleukin-2 receptor",
            "attributes": null
          },
          {
            "code": "1148890003",
            "description": "Hemophagocytic lymphohistiocytosis due to malignant disease",
            "attributes": null
          },
          {
            "code": "1179284005",
            "description": "Severe combined immunodeficiency due to linker for activation of T cells deficiency",
            "attributes": null
          },
          {
            "code": "1179285006",
            "description": "Combined immunodeficiency due to moesin deficiency",
            "attributes": null
          },
          {
            "code": "1179286007",
            "description": "Combined immunodeficiency due to GINS complex subunit 1 deficiency",
            "attributes": null
          },
          {
            "code": "1179288008",
            "description": "Combined immunodeficiency due to transferrin receptor deficiency",
            "attributes": null
          },
          {
            "code": "1186712009",
            "description": "Combined immunodeficiency due to capping protein regulator and myosin 1 linker 2 deficiency",
            "attributes": null
          },
          {
            "code": "1186714005",
            "description": "Combined immunodeficiency due to interleukin-2 inducible T cell kinase deficiency",
            "attributes": null
          },
          {
            "code": "1186715006",
            "description": "Combined immunodeficiency due to CD70 deficiency",
            "attributes": null
          },
          {
            "code": "1187623009",
            "description": "Phosphoglucomutase 3-related congenital disorder of glycosylation",
            "attributes": null
          },
          {
            "code": "1197205005",
            "description": "Combined immunodeficiency due to dedicator of cytokinesis 8 deficiency",
            "attributes": null
          },
          {
            "code": "1197428008",
            "description": "Combined immunodeficiency, enteropathy spectrum",
            "attributes": null
          },
          {
            "code": "1197477000",
            "description": "Combined immunodeficiency due to lipopolysaccharide-responsive beige-like anchor protein deficiency",
            "attributes": null
          },
          {
            "code": "1222681008",
            "description": "Autoimmune hemolytic anemia, autoimmune thrombocytopenia, primary immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "1229940001",
            "description": "Autosomal recessive T-cell negative, B-cell positive severe combined immunodeficiency due to interleukin 7 receptor deficiency",
            "attributes": null
          },
          {
            "code": "1229941002",
            "description": "Autosomal recessive T-cell negative, B-cell positive severe combined immunodeficiency due to protein tyrosine phosphatase receptor type C deficiency",
            "attributes": null
          },
          {
            "code": "1229942009",
            "description": "Severe combined immunodeficiency due to coronin 1A deficiency",
            "attributes": null
          },
          {
            "code": "1260096003",
            "description": "Wasting syndrome due to acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "190993005",
            "description": "Autosomal recessive severe combined immunodeficiency",
            "attributes": null
          },
          {
            "code": "190996002",
            "description": "Severe combined immunodeficiency with reticular dysgenesis",
            "attributes": null
          },
          {
            "code": "190997006",
            "description": "Severe combined immunodeficiency with low T- and B-cell numbers",
            "attributes": null
          },
          {
            "code": "190998001",
            "description": "Severe combined immunodeficiency with low or normal B-cell numbers",
            "attributes": null
          },
          {
            "code": "203592006",
            "description": "X-linked severe combined immunodeficiency",
            "attributes": null
          },
          {
            "code": "22406001",
            "description": "Severe combined immunodeficiency due to absent lymphoid stem cells",
            "attributes": null
          },
          {
            "code": "234437005",
            "description": "Hemophagocytic lymphohistiocytosis",
            "attributes": null
          },
          {
            "code": "234557006",
            "description": "Anti-polysaccharide antibody deficiency",
            "attributes": null
          },
          {
            "code": "234559009",
            "description": "Anti-pneumococcal polysaccharide antibody deficiency",
            "attributes": null
          },
          {
            "code": "234570002",
            "description": "Severe combined immunodeficiency with maternofetal engraftment",
            "attributes": null
          },
          {
            "code": "234632005",
            "description": "Immunodeficiency associated with chromosomal abnormality",
            "attributes": null
          },
          {
            "code": "234640004",
            "description": "18-p syndrome with associated immunodeficiency",
            "attributes": null
          },
          {
            "code": "234641000",
            "description": "Immunodeficiency associated with multiple organ system abnormalities",
            "attributes": null
          },
          {
            "code": "25109007",
            "description": "Lymphopenic agammaglobulinemia - short-limbed dwarfism syndrome",
            "attributes": null
          },
          {
            "code": "276665006",
            "description": "Congenital acquired immune deficiency syndrome",
            "attributes": null
          },
          {
            "code": "31323000",
            "description": "Severe combined immunodeficiency disease",
            "attributes": null
          },
          {
            "code": "3439009",
            "description": "Severe combined immunodeficiency due to absent peripheral T cell maturation",
            "attributes": null
          },
          {
            "code": "351287008",
            "description": "Reticular dysgenesis with congenital aleukocytosis",
            "attributes": null
          },
          {
            "code": "36070007",
            "description": "Wiskott-Aldrich syndrome",
            "attributes": null
          },
          {
            "code": "36138009",
            "description": "Congenital immunodeficiency disease",
            "attributes": null
          },
          {
            "code": "362993009",
            "description": "Autosomal recessive severe combined immunodeficiency disease",
            "attributes": null
          },
          {
            "code": "363040003",
            "description": "Congenital immunodeficiency involving the hematopoietic system",
            "attributes": null
          },
          {
            "code": "36980009",
            "description": "Severe combined immunodeficiency due to absent adenosine deaminase",
            "attributes": null
          },
          {
            "code": "396330006",
            "description": "Celiac crisis",
            "attributes": null
          },
          {
            "code": "396331005",
            "description": "Celiac disease",
            "attributes": null
          },
          {
            "code": "398250003",
            "description": "Familial hemophagocytic lymphohistiocytosis",
            "attributes": null
          },
          {
            "code": "403837005",
            "description": "Wiskott-Aldrich autosomal dominant variant syndrome",
            "attributes": null
          },
          {
            "code": "416729007",
            "description": "Neutropenia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "420403001",
            "description": "Pneumocystosis with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "420544002",
            "description": "Bacterial pneumonia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "420787001",
            "description": "Pneumococcal pneumonia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "421047005",
            "description": "Candidiasis of lung with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "421102007",
            "description": "Aplastic anemia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "421312009",
            "description": "Agranulocytosis with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "421508002",
            "description": "Viral pneumonia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "421671002",
            "description": "Pneumonia with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "422003001",
            "description": "Cachexia associated with acquired immunodeficiency syndrome",
            "attributes": null
          },
          {
            "code": "426202004",
            "description": "Immune reconstitution inflammatory syndrome",
            "attributes": null
          },
          {
            "code": "442459007",
            "description": "Combined immunodeficiency disease",
            "attributes": null
          },
          {
            "code": "44940001",
            "description": "Adenosine deaminase deficiency",
            "attributes": null
          },
          {
            "code": "45259000",
            "description": "Celiac infantilism",
            "attributes": null
          },
          {
            "code": "45390000",
            "description": "Severe combined immunodeficiency due to absent interleukin-2 production",
            "attributes": null
          },
          {
            "code": "49555001",
            "description": "Severe combined immunodeficiency due to absent T cell receptor",
            "attributes": null
          },
          {
            "code": "55602000",
            "description": "Nezelof's syndrome",
            "attributes": null
          },
          {
            "code": "60743005",
            "description": "Purine-nucleoside phosphorylase deficiency",
            "attributes": null
          },
          {
            "code": "61715008",
            "description": "Celiac disease with diffuse intestinal ulceration",
            "attributes": null
          },
          {
            "code": "62479008",
            "description": "Acquired immune deficiency syndrome",
            "attributes": null
          },
          {
            "code": "713297001",
            "description": "Candidiasis of esophagus co-occurrent with human immunodeficiency virus infection",
            "attributes": null
          },
          {
            "code": "715982006",
            "description": "Severe combined immunodeficiency due to deoxyribonucleic acid cross-link repair protein 1c deficiency",
            "attributes": null
          },
          {
            "code": "716378008",
            "description": "Combined immunodeficiency due to Zeta-chain associated protein kinase 70 deficiency",
            "attributes": null
          },
          {
            "code": "716871006",
            "description": "Severe combined immunodeficiency due to deoxyribonucleic acid dependent protein kinase catalytic subunit deficiency",
            "attributes": null
          },
          {
            "code": "717811007",
            "description": "Combined immunodeficiency due to calcium release activated calcium channel dysfunction",
            "attributes": null
          },
          {
            "code": "718107000",
            "description": "Severe combined immunodeficiency T-cell negative B-cell positive due to janus kinase-3 deficiency",
            "attributes": null
          },
          {
            "code": "71904008",
            "description": "Severe combined immunodeficiency due to absent class II human leukocyte antigens",
            "attributes": null
          },
          {
            "code": "720853005",
            "description": "Severe combined immunodeficiency, microcephaly, growth retardation, sensitivity to ionizing radiation syndrome",
            "attributes": null
          },
          {
            "code": "722067005",
            "description": "Omenn syndrome",
            "attributes": null
          },
          {
            "code": "722386009",
            "description": "Celiac disease with epilepsy and cerebral calcification syndrome",
            "attributes": null
          },
          {
            "code": "724177005",
            "description": "Ligase 4 syndrome",
            "attributes": null
          },
          {
            "code": "724641002",
            "description": "Primary hemophagocytic lymphohistiocytosis",
            "attributes": null
          },
          {
            "code": "725135004",
            "description": "Combined immunodeficiency due to CD3gamma deficiency",
            "attributes": null
          },
          {
            "code": "725290000",
            "description": "Combined immunodeficiency due to partial recombination-activating gene 1 deficiency",
            "attributes": null
          },
          {
            "code": "735527002",
            "description": "Human immunodeficiency virus World Health Organization 2007 stage 4 co-occurrent with tuberculosis",
            "attributes": null
          },
          {
            "code": "735528007",
            "description": "Human immunodeficiency virus World Health Organization 2007 stage 4 co-occurrent with malaria",
            "attributes": null
          },
          {
            "code": "737381004",
            "description": "World Health Organization 2007 Human immunodeficiency virus infection clinical stage 4",
            "attributes": null
          },
          {
            "code": "763623001",
            "description": "Severe combined immunodeficiency due to cytidine 5-prime triphosphate synthetase 1 deficiency",
            "attributes": null
          },
          {
            "code": "765145001",
            "description": "T cell negative B cell positive severe combined immunodeficiency due to gamma chain deficiency",
            "attributes": null
          },
          {
            "code": "765188009",
            "description": "Severe combined immunodeficiency due to complete recombination-activating gene 1 and/or recombination-activating gene 2 deficiency",
            "attributes": null
          },
          {
            "code": "766879006",
            "description": "Combined immunodeficiency due to OX40 deficiency",
            "attributes": null
          },
          {
            "code": "770625006",
            "description": "Combined immunodeficiency with faciooculoskeletal anomalies syndrome",
            "attributes": null
          },
          {
            "code": "771479000",
            "description": "Combined immunodeficiency due to serine/threonine kinase 4 deficiency",
            "attributes": null
          },
          {
            "code": "771517009",
            "description": "Severe combined immunodeficiency due to caspase recruitment domain family member 11 deficiency",
            "attributes": null
          },
          {
            "code": "782751003",
            "description": "Severe combined immunodeficiency due to inhibitor of nuclear factor kappa B kinase subunit beta deficiency",
            "attributes": null
          },
          {
            "code": "782915004",
            "description": "Acquired hemophagocytic lymphohistiocytosis associated with malignant disease",
            "attributes": null
          },
          {
            "code": "783617001",
            "description": "Severe combined immunodeficiency due to lymphocyte-specific protein-tyrosine kinase deficiency",
            "attributes": null
          },
          {
            "code": "783743009",
            "description": "Combined immunodeficiency with granulomatosis",
            "attributes": null
          },
          {
            "code": "784340000",
            "description": "Combined immunodeficiency due to interleukin 21 receptor deficiency",
            "attributes": null
          }
        ]
      }
    ],
    "coding_system_release": "",
    "open_codelist_version_id": "60b44058",
    "open_codelist_version_tag": "20250912",
    "status": 1,
    "doi": "https://doi.org/10.48533/fs8v-s671",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 3,
      "name": "OpenCodelists Phenotype",
      "description": "OpenSafely's OpenCodelist Phenotype, visit https://www.opencodelists.org/ to learn more",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 7738,
        "version_name": "Severely immunocompromised codes",
        "version_date": "2026-01-26T22:57:40.153893Z",
        "is_published": true,
        "is_latest": true
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        "version_id": 7737,
        "version_name": "Severely immunocompromised codes",
        "version_date": "2026-01-26T22:57:38.842791Z",
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        "version_id": 7736,
        "version_name": "Severely immunocompromised codes",
        "version_date": "2026-01-26T22:57:37.471036Z",
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        "version_id": 7735,
        "version_name": "Severely immunocompromised codes",
        "version_date": "2026-01-26T22:57:36.009578Z",
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    ]
  }
]