[
  {
    "phenotype_id": "PH304",
    "phenotype_version_id": 608,
    "name": "Sickle-cell anaemia",
    "definition": "At the specified date, a patient is defined as having had Sickle-cell anaemia IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:\n\n\nPrimary care\n\n\n1. Sickle-cell anaemia diagnosis or history of diagnosis during a consultation \n\nOR\nSecondary care (ICD10)\n\n\n1. ALL diagnoses of Sickle-cell anaemia or history of diagnosis during a hospitalization\n\n\n\n\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": "10.1016/S2589-7500(19)30012-3",
        "details": "Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3"
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:11:55.964343Z",
    "author": "Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A",
    "collections": [
      {
        "name": "CALIBER",
        "value": 21
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:11:55.964371Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "https://kclhi.org/phenoflow/workflows/github.com/phenoflow/Sickle-cell-anaemia---d464dde0-17be-11ef-9de4-4d4ea830ad16/blob/read-potential-cases-fhir/Sickle-cell-anaemia.cwl",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      },
      {
        "name": "HES Admitted Patient Care data for CPRD GOLD",
        "value": 9,
        "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43",
        "url": "https://healthdatagateway.org/en/dataset/674",
        "datasource_id": 674
      }
    ],
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v2",
        "value": 5
      },
      {
        "name": "Med codes",
        "value": 8
      }
    ],
    "event_date_range": "01/01/1999 - 01/07/2016",
    "concept_information": [
      {
        "concept_id": 1556,
        "concept_version_id": 4251,
        "concept_name": "Sickle-cell anaemia - Primary care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH304",
        "phenotype_version_id": 608,
        "phenotype_name": "Sickle-cell anaemia",
        "code_attribute_header": [
          "Disease",
          "Medcode",
          "Category"
        ],
        "codes": [
          {
            "code": "1458.00",
            "description": "History of sickle cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "100001.0",
              "Category": "History of Sickle-cell anaemia"
            }
          },
          {
            "code": "D104211",
            "description": "Sickle-cell thalassaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "31075.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106.00",
            "description": "Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "23519.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106000",
            "description": "Sickle-cell anaemia of unspecified type",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "69964.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106100",
            "description": "Sickle-cell anaemia with no crisis",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "32937.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106200",
            "description": "Sickle-cell anaemia with crisis",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "31370.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106300",
            "description": "Sickle-cell anaemia with haemoglobin C disease",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "31306.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106400",
            "description": "Sickle-cell anaemia with haemoglobin D disease",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "8119.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106500",
            "description": "Sickle-cell anaemia with haemoglobin E disease",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "93872.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D106z00",
            "description": "Sickle-cell anaemia NOS",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "57397.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "Dyu1200",
            "description": "[X]Other sickle-cell disorders",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "48295.0",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "F422100",
            "description": "Proliferative retinopathy due to sickle cell disease",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "11874.0",
              "Category": "History of Sickle-cell anaemia"
            }
          },
          {
            "code": "K0G..00",
            "description": "Sickle cell nephropathy",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Medcode": "107027.0",
              "Category": "History of Sickle-cell anaemia"
            }
          }
        ]
      },
      {
        "concept_id": 1557,
        "concept_version_id": 4253,
        "concept_name": "Sickle-cell anaemia - Primary care",
        "coding_system": {
          "id": 8,
          "name": "Med codes",
          "description": "Med codes"
        },
        "phenotype_id": "PH304",
        "phenotype_version_id": 608,
        "phenotype_name": "Sickle-cell anaemia",
        "code_attribute_header": [
          "Disease",
          "ReadcodeDescr",
          "Readcode"
        ],
        "codes": [
          {
            "code": "100001.0",
            "description": "History of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "History of sickle cell anaemia",
              "Readcode": "1458.00"
            }
          },
          {
            "code": "107027.0",
            "description": "History of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle cell nephropathy",
              "Readcode": "K0G..00"
            }
          },
          {
            "code": "11874.0",
            "description": "History of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Proliferative retinopathy due to sickle cell disease",
              "Readcode": "F422100"
            }
          },
          {
            "code": "23519.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia",
              "Readcode": "D106.00"
            }
          },
          {
            "code": "31075.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell thalassaemia",
              "Readcode": "D104211"
            }
          },
          {
            "code": "31306.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia with haemoglobin C disease",
              "Readcode": "D106300"
            }
          },
          {
            "code": "31370.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia with crisis",
              "Readcode": "D106200"
            }
          },
          {
            "code": "32937.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia with no crisis",
              "Readcode": "D106100"
            }
          },
          {
            "code": "48295.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "[X]Other sickle-cell disorders",
              "Readcode": "Dyu1200"
            }
          },
          {
            "code": "57397.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia NOS",
              "Readcode": "D106z00"
            }
          },
          {
            "code": "69964.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia of unspecified type",
              "Readcode": "D106000"
            }
          },
          {
            "code": "8119.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia with haemoglobin D disease",
              "Readcode": "D106400"
            }
          },
          {
            "code": "93872.0",
            "description": "Diagnosis of Sickle-cell anaemia",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "ReadcodeDescr": "Sickle-cell anaemia with haemoglobin E disease",
              "Readcode": "D106500"
            }
          }
        ]
      },
      {
        "concept_id": 1558,
        "concept_version_id": 4255,
        "concept_name": "Sickle-cell anaemia - Secondary care - Diagnoses",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH304",
        "phenotype_version_id": 608,
        "phenotype_name": "Sickle-cell anaemia",
        "code_attribute_header": [
          "Disease",
          "Category"
        ],
        "codes": [
          {
            "code": "D57.0",
            "description": "Sickle-cell anaemia with crisis",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D57.1",
            "description": "Sickle-cell anaemia without crisis",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D57.2",
            "description": "Double heterozygous sickling disorders",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          },
          {
            "code": "D57.8",
            "description": "Other sickle-cell disorders",
            "attributes": {
              "Disease": "Sickle-cell anaemia",
              "Category": "Diagnosis of Sickle-cell anaemia"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/2gmq-0x96",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 608,
        "version_name": "Sickle-cell anaemia",
        "version_date": "2021-10-06T16:11:55.991694Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]