[
  {
    "phenotype_id": "PH3542",
    "phenotype_version_id": 8609,
    "name": "Long acting opioids greater than or equal to 120mg per day OME",
    "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\n\\#\\#\\#\\#\\# User requirements\nA codelist is needed of all long acting opioids with an oral morphine equivalence (OME) of \\>\\= 120mg \\- used for analgesia (any route) excluding cough suppression, motility, general anaesthesia, opiate use disorder \\- this is for a project looking at opioid prescribing for patients on hospital waiting lists.\n\n\n##### Sensitivity versus specificity\n\n\nAny opioid as a modified release formulation or transdermal patch with daily OME \\>\\=120mg based on standard dosing.\n\n\n##### Relevant definitions or links to important reference sources\n\n\nOpioid equivalence \\- https://fpm.ac.uk/opioids\\-aware\\-structured\\-approach\\-opioid\\-prescribing/dose\\-equivalents\\-and\\-changing\\-opioids\n\n\n##### Existing relevant codelists\n\n\nNil\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n",
    "implementation": null,
    "publications": null,
    "validation": null,
    "citation_requirements": null,
    "created": "2026-01-26T23:21:35.846466Z",
    "author": "OpenSAFELY",
    "collections": [
      {
        "name": "OpenCodelist",
        "value": 31
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": {
      "id": 1,
      "slug": "opensafely",
      "name": "OpenSAFELY"
    },
    "world_access": 1,
    "updated": "2026-01-26T23:21:35.841776Z",
    "references": [
      {
        "url": "https://github.com/opensafely/codelist-development/issues/294",
        "title": "GitHub issue"
      }
    ],
    "signed_off": [],
    "methodology": "##### Search terms / synonyms / search strategy\n\n\nBigQuery used to identify relevant products from BNF data. \ndm\\+d data used to filter for modified release/patch versions as appropriate.\nFaculty of Pain Medicine OME conversions used to calculate daily OME \\- usual licensed dosing used to determine OME (for example morphine sulphate MR products licensed for twice a day administration (with exception of MXL) \\- so if prescribed 60mg tablet assume taking twice a day (120mg / day total) \\- or for MXL assume taking once a day so would be prescribed 120mg tablet to meet 120mg/day total.\n\n\n\n```\n  SELECT DISTINCT presentation_code as code, presentation as term\n  FROM hscic.bnf p \n  INNER JOIN dmd.vmp vmp ON CONCAT(SUBSTR(p.presentation_code,0,9),'AA', SUBSTR(p.presentation_code,-2), SUBSTR(p.presentation_code,-2)) = vmp.bnf_code\n  INNER JOIN dmd.vpi AS vpi ON vmp.id = vpi.vmp\n  INNER JOIN dmd.ont AS ont ON vmp.id = ont.vmp\n  INNER JOIN dmd.ontformroute AS route ON ont.form = route.cd\n  WHERE\n  ((vpi.ing = (60886004) AND route.descr LIKE '%modified-release.oral' AND p.presentation NOT LIKE '%MXL%' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=60) /* Morphine Sulfate MR oral preps [excluding MXL as 24hr] (strengths equal to or higher than 60mg) (ing code) */\n  OR (vpi.ing = (60886004) AND route.descr LIKE '%modified-release.oral' AND p.presentation LIKE '%MXL%' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=120) /* MXL (strengths equal to or higher than 120mg) (ing code) */\n  OR (vpi.ing = 387024006 AND route.descr LIKE '%modified-release.oral' AND p.presentation NOT LIKE '%Onexila%' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=40) /* Oxycodone MR oral preps [excluding Onexila as 24hr] (strengths equal to or higher than 40mg) (ing code) */\n  OR (vpi.ing = 387024006 AND route.descr LIKE '%modified-release.oral' AND p.presentation LIKE '%Onexila%' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=80) /* Oxycodone MR oral preps [only Onexila as 24hr] (strengths equal to or higher than 80mg) (ing code) */\n  OR (vpi.ing IN (441757005, 442699004,40755011000001109)  AND route.descr LIKE '%modified-release.oral' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=150) /* Tapentadol HCl/Phosphate MR oral preps (strengths equal to or higher than 150mg) (ing code) */\n  OR (vpi.ing IN (386858008, 108505002) AND route.descr LIKE '%modified-release.oral' AND (p.presentation NOT LIKE '%Tradorec XL%' OR p.presentation NOT LIKE '%Zamadol 24hr%' OR p.presentation NOT LIKE '%Zydol XL%' OR p.presentation NOT LIKE '%Dromadol XL%') AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=600) /* Tramadol HCl/ Tramadol MR 12 hour oral preps (strengths equal to or higher than x) (ing code) */\n  OR (vpi.ing IN (386858008, 108505002) AND route.descr LIKE '%modified-release.oral' AND (p.presentation LIKE '%Tradorec XL%' OR p.presentation LIKE '%Zamadol 24hr%' OR p.presentation LIKE '%Zydol XL%' OR p.presentation LIKE '%Dromadol XL%') AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=1200) /* Tramadol HCl/ Tramadol MR 24 hour oral preps (strengths equal to or higher than x) (ing code) */\n  OR (vpi.ing IN (44508008, 387485001) AND route.descr LIKE '%modified-release.oral' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=12) /* Hydromorphone (strengths equal to or higher than 120mg) (ing code) */\n  OR (vpi.ing IN (322538006, 387322000) AND route.descr LIKE '%modified-release.oral' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=600) /* Dihydrocodeine (strengths equal to or higher than 120mg) (ing code) */\n  OR (vpi.ing = (387173000)  AND route.descr LIKE 'patch.transdermal' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=52.5) /* Buprenorphine patches (strengths equal to or higher than 52.5mg/hour) (ing code) */\n  OR (vpi.ing = 373492002 AND route.descr = 'patch.transdermal' AND strnt_nmrtr_val/(COALESCE(strnt_dnmtr_val,1)) >=50)) /* Fentanyl patches (strengths equal to or higher than 50mcg/hour) (ing code) */\n  GROUP BY code, term\n\n```\n\n##### Inclusion criteria for codes\n\n\nAny modified release or transdermal opioid with daily OME \\>120mg/day (based on licensed dosing).\n\n\n##### Exclusion criteria for codes\n\n\nN/A\n\n\n##### Borderline cases\n\n\nN/A\n\n",
    "coding_system": [
      {
        "name": "BNF codes",
        "value": 11
      }
    ],
    "open_codelist_id": "opensafely/long-acting-opioids-greater-than-or-equal-to-120mg-per-day-ome",
    "source_reference": "https://www.opencodelists.org/codelist/opensafely/long-acting-opioids-greater-than-or-equal-to-120mg-per-day-ome/2261801e",
    "concept_information": [
      {
        "concept_id": 8786,
        "concept_version_id": 16271,
        "concept_name": "opensafely/long-acting-opioids-greater-than-or-equal-to-120mg-per-day-ome/2261801e",
        "coding_system": {
          "id": 11,
          "name": "BNF codes",
          "description": "BNF codes"
        },
        "phenotype_id": "PH3542",
        "phenotype_version_id": 8609,
        "phenotype_name": "Long acting opioids greater than or equal to 120mg per day OME",
        "code_attribute_header": [],
        "codes": [
          {
            "code": "040702050AAAAAA",
            "description": "Hydromorphone 16mg modified-release capsules",
            "attributes": null
          },
          {
            "code": "040702050AAABAB",
            "description": "Hydromorphone 24mg modified-release capsules",
            "attributes": null
          },
          {
            "code": "040702050BBAFAA",
            "description": "Palladone SR 16mg capsules",
            "attributes": null
          },
          {
            "code": "040702050BBAGAB",
            "description": "Palladone SR 24mg capsules",
            "attributes": null
          },
          {
            "code": "0407020A0AAAFAF",
            "description": "Fentanyl 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0AAAGAG",
            "description": "Fentanyl 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0AAAHAH",
            "description": "Fentanyl 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBABAF",
            "description": "Durogesic 50micrograms transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBACAG",
            "description": "Durogesic 75micrograms transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBADAH",
            "description": "Durogesic 100micrograms transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBAJAF",
            "description": "Durogesic DTrans 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBAKAG",
            "description": "Durogesic DTrans 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BBALAH",
            "description": "Durogesic DTrans 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BDABAF",
            "description": "Tilofyl 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BDACAG",
            "description": "Tilofyl 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BDADAH",
            "description": "Tilofyl 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BEACAF",
            "description": "Matrifen 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BEADAG",
            "description": "Matrifen 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BEAEAH",
            "description": "Matrifen 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BFACAF",
            "description": "Mezolar Matrix 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BFADAG",
            "description": "Mezolar Matrix 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BFAEAH",
            "description": "Mezolar Matrix 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BGABAF",
            "description": "Fentalis Reservoir 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BGACAG",
            "description": "Fentalis Reservoir 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BGADAH",
            "description": "Fentalis Reservoir 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BHABAF",
            "description": "Osmach 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BHACAG",
            "description": "Osmach 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BHADAH",
            "description": "Osmach 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BLABAF",
            "description": "Osmanil 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BLACAG",
            "description": "Osmanil 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BLADAH",
            "description": "Osmanil 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BMABAF",
            "description": "Victanyl 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BMACAG",
            "description": "Victanyl 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BMADAH",
            "description": "Victanyl 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BQACAF",
            "description": "Fencino 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BQADAG",
            "description": "Fencino 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BQAEAH",
            "description": "Fencino 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BRACAG",
            "description": "Opiodur 75micrograms/hour transdermal patches (Pfizer)",
            "attributes": null
          },
          {
            "code": "0407020A0BRADAH",
            "description": "Opiodur 100micrograms/hour transdermal patches (Pfizer)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAEAF",
            "description": "Opiodur 50micrograms/hour transdermal patches (Pfizer)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAHAF",
            "description": "Opiodur 50micrograms/hour transdermal patches (RX Farma)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAIAG",
            "description": "Opiodur 75micrograms/hour transdermal patches (RX Farma)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAJAH",
            "description": "Opiodur 100micrograms/hour transdermal patches (RX Farma)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAMAF",
            "description": "Opiodur 50micrograms/hour transdermal patches (Zentiva)",
            "attributes": null
          },
          {
            "code": "0407020A0BRANAG",
            "description": "Opiodur 75micrograms/hour transdermal patches (Zentiva)",
            "attributes": null
          },
          {
            "code": "0407020A0BRAPAH",
            "description": "Opiodur 100micrograms/hour transdermal patches (Zentiva)",
            "attributes": null
          },
          {
            "code": "0407020A0BUACAF",
            "description": "Mylafent 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BUADAG",
            "description": "Mylafent 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BUAEAH",
            "description": "Mylafent 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BVACAF",
            "description": "Yemex 50micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BVADAG",
            "description": "Yemex 75micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020A0BVAEAH",
            "description": "Yemex 100micrograms/hour transdermal patches",
            "attributes": null
          },
          {
            "code": "0407020ADAAAHAH",
            "description": "Oxycodone 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADAAAIAI",
            "description": "Oxycodone 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADAAAPAP",
            "description": "Oxycodone 120mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADAAAQAQ",
            "description": "Oxycodone 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBCACAH",
            "description": "OxyContin 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBCADAI",
            "description": "OxyContin 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBCAFAP",
            "description": "OxyContin 120mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBCAGAQ",
            "description": "OxyContin 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBDADAH",
            "description": "Carexil 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBDAEAI",
            "description": "Carexil 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBEADAH",
            "description": "Longtec 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBEAEAI",
            "description": "Longtec 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBEAFAP",
            "description": "Longtec 120mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBEAIAQ",
            "description": "Longtec 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBFADAH",
            "description": "Oxylan 40mg modified-release tablets (Chanelle Medical)",
            "attributes": null
          },
          {
            "code": "0407020ADBFAEAI",
            "description": "Oxylan 80mg modified-release tablets (Chanelle Medical)",
            "attributes": null
          },
          {
            "code": "0407020ADBFAIAH",
            "description": "Oxylan 40mg modified-release tablets (Actavis)",
            "attributes": null
          },
          {
            "code": "0407020ADBFAJAI",
            "description": "Oxylan 80mg modified-release tablets (Actavis)",
            "attributes": null
          },
          {
            "code": "0407020ADBGADAH",
            "description": "Candox 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBGAEAI",
            "description": "Candox 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBIABAH",
            "description": "Dolocodon PR 40mg tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBKADAH",
            "description": "Reltebon 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBKAEAI",
            "description": "Reltebon 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBKAHAQ",
            "description": "Reltebon 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBLABAI",
            "description": "Oxeltra 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBLADAQ",
            "description": "Oxeltra 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBLAEAH",
            "description": "Oxeltra 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBMAEAH",
            "description": "Abtard 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBMAGAQ",
            "description": "Abtard 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBMAHAI",
            "description": "Abtard 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBNAAAI",
            "description": "Zomestine 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBNABAH",
            "description": "Zomestine 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBPAEAH",
            "description": "Leveraxo 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBPAFAQ",
            "description": "Leveraxo 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBPAGAI",
            "description": "Leveraxo 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBQADAI",
            "description": "Onexila XL 80mg tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBRAFAH",
            "description": "Renocontin 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBRAGAQ",
            "description": "Renocontin 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBSAFAH",
            "description": "Oxypro 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBSAGAQ",
            "description": "Oxypro 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBSAHAI",
            "description": "Oxypro 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBTAFAH",
            "description": "Ixyldone 40mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBTAGAQ",
            "description": "Ixyldone 60mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020ADBTAHAI",
            "description": "Ixyldone 80mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AFAAADAD",
            "description": "Oxycodone 40mg / Naloxone 20mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AFBBADAD",
            "description": "Targinact 40mg/20mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AFBCACAD",
            "description": "Myloxifin 40mg/20mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AFBDADAD",
            "description": "Oxyargin 40mg/20mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AGAAAEAE",
            "description": "Tapentadol 150mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AGAAAFAF",
            "description": "Tapentadol 200mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AGAAAGAG",
            "description": "Tapentadol 250mg modified-release tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBBAEAE",
            "description": "Palexia SR 150mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBBAFAF",
            "description": "Palexia SR 200mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBBAGAG",
            "description": "Palexia SR 250mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBCADAE",
            "description": "Ationdo SR 150mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBCAEAF",
            "description": "Ationdo SR 200mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AGBCAFAG",
            "description": "Ationdo SR 250mg tablets",
            "attributes": null
          },
          {
            "code": "0407020AHAAACAC",
            "description": "Tapentadol 150mg modified-release capsules",
            "attributes": null
          },
          {
            "code": "0407020AHAAADAD",
            "description": "Tapentadol 200mg modified-release capsules",
            "attributes": null
          },
          {
            "code": "0407020AHAAAEAE",
            "description": "Tapentadol 250mg modified-release capsules",
            "attributes": null
          },
          {
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