[ { "phenotype_id": "PH3780", "phenotype_version_id": 8929, "name": "Teratogenic medicines", "definition": "This codelist was taken from [OpenCodelists](https://www.opencodelists.org/), created by [OpenSAFELY](https://www.opensafely.org/). We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.\n\n\nIn this codelist we aim to identify teratogenic drugs. A teratogen is a substance that can cause abnormalities or birth defects in a developing fetus.\n\n\nThe CQC routinely review the use of the following drugs, in female patients between the age of 8 and 55 years old Valproate Carbimazole Modafinil Pregabalin Topiramate.\n\n\nThere are other drugs that are considered teratogenic but only these five are considered here.\n\n\n© University of Oxford for the Bennett Institute for Applied Data Science 2025\\. This work may be copied freely for non\\-commercial research and study.\n\n", "implementation": null, "publications": null, "validation": null, "citation_requirements": null, "created": "2026-01-26T23:34:18.266180Z", "author": "OpenSAFELY", "collections": [ { "name": "OpenCodelist", "value": 31 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": { "id": 1, "slug": "opensafely", "name": "OpenSAFELY" }, "world_access": 1, "updated": "2026-01-26T23:34:24.740078Z", "references": [ { "url": "https://www.gov.uk/guidance/valproate-use-by-women-and-girls", "title": "MHRA - Valproate use by women and girls" }, { "url": "https://www.gov.uk/drug-safety-update/carbimazole-increased-risk-of-congenital-malformations-strengthened-advice-on-contraception", "title": "MHRA - Carbimazole is associated with an increased risk of congenital malformations" }, { "url": "https://www.gov.uk/drug-safety-update/topiramate-topamax-start-of-safety-review-triggered-by-a-study-reporting-an-increased-risk-of-neurodevelopmental-disabilities-in-children-with-prenatal-exposure", "title": "MHRA: Topiramate safety review - increased risk of congenital malformations and effects on fetal growth if used during pregnancy" }, { "url": "https://www.gov.uk/drug-safety-update/modafinil-provigil-increased-risk-of-congenital-malformations-if-used-during-pregnancy", "title": "MHRA: Modafinil - increased risk of congenital malformations if used during pregnancy" }, { "url": "https://www.gov.uk/government/publications/pregabalin-and-risks-in-pregnancy", "title": "MHRA: Pregabalin - increased risk of physical birth abnormalities in the baby" } ], "signed_off": [], "methodology": "Methodology\nSearched for the following terms: Sodium Valproate / Valproic acid Modafinil / Pregabalin / Carbimazole / Topiramate\n\n\nExcluded Parenteral preparations such as sodium valporate as an infusiion\n\n\nBorderline Cases Nil\n\n\nReferences\nMHRA \\- Valproate use by women and girls\nMHRA \\- Carbimazole is associated with an increased risk of congenital malformations\nMHRA: Topiramate safety review \\- increased risk of congenital malformations and effects on fetal growth if used during pregnancy\nMHRA: Modafinil \\- increased risk of congenital malformations if used during pregnancy\nMHRA: Pregabalin \\- increased risk of physical birth abnormalities in the baby\n\n", "coding_system": [ { "name": "dm+d codes", "value": 23 } ], "open_codelist_id": "opensafely/teratogenic-medicines", "source_reference": "https://www.opencodelists.org/codelist/opensafely/teratogenic-medicines/339a925c", "concept_information": [ { "concept_id": 9106, "concept_version_id": 16591, "concept_name": "opensafely/teratogenic-medicines/339a925c", "coding_system": { "id": 23, "name": "dm+d codes", "description": "dm+d codes" }, "phenotype_id": "PH3780", "phenotype_version_id": 8929, 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"description": "Pregabalin 100mg capsules", "attributes": { "dmd_id": "415161007", "dmd_type": "VMP", "bnf_code": "0408010AEAAADAD" } }, { "code": "415162000", "description": "Pregabalin 150mg capsules", "attributes": { "dmd_id": "415162000", "dmd_type": "VMP", "bnf_code": "0408010AEAAAEAE" } }, { "code": "415163005", "description": "Pregabalin 200mg capsules", "attributes": { "dmd_id": "415163005", "dmd_type": "VMP", "bnf_code": "0408010AEAAAFAF" } }, { "code": "415164004", "description": "Pregabalin 25mg capsules", "attributes": { "dmd_id": "415164004", "dmd_type": "VMP", "bnf_code": "0408010AEAAAAAA" } }, { "code": "415165003", "description": "Pregabalin 300mg capsules", "attributes": { "dmd_id": "415165003", "dmd_type": "VMP", "bnf_code": "0408010AEAAAGAG" } }, { "code": "415166002", "description": "Pregabalin 50mg capsules", "attributes": { "dmd_id": "415166002", "dmd_type": "VMP", "bnf_code": "0408010AEAAABAB" } }, { "code": "415167006", "description": "Pregabalin 75mg capsules", "attributes": { "dmd_id": "415167006", "dmd_type": "VMP", "bnf_code": "0408010AEAAACAC" } }, { "code": "42014611000001101", "description": "VMP subsequent to 323385006", "attributes": { "dmd_id": "42014611000001101", "dmd_type": "VMP", "bnf_code": "0404000R0AAAAAA" } }, { "code": "42014711000001105", "description": "VMP subsequent to 407861004", "attributes": { "dmd_id": "42014711000001105", "dmd_type": "VMP", "bnf_code": "0404000R0AAACAC" } }, { "code": "4205011000001105", "description": "Topamax 15mg sprinkle capsules", "attributes": { "dmd_id": "4205011000001105", "dmd_type": "AMP", "bnf_code": "040801050BBAEAU" } }, { "code": "4206011000001101", "description": "Topamax 25mg sprinkle capsules", "attributes": { "dmd_id": "4206011000001101", "dmd_type": "AMP", "bnf_code": "040801050BBAFAV" } }, { "code": "4206411000001105", "description": "Topamax 50mg sprinkle capsules", "attributes": { "dmd_id": "4206411000001105", "dmd_type": "AMP", "bnf_code": "040801050BBAGAW" } }, { "code": "42080911000001104", "description": "VMP subsequent to 325328008", "attributes": { "dmd_id": "42080911000001104", "dmd_type": "VMP", "bnf_code": "0602020D0AAABAB" } }, { "code": "42081011000001107", "description": "VMP subsequent to 325329000", "attributes": { "dmd_id": "42081011000001107", "dmd_type": "VMP", "bnf_code": "0602020D0AAAAAA" } }, { "code": "421070002", "description": "Pregabalin 225mg capsules", "attributes": { "dmd_id": "421070002", "dmd_type": "VMP", "bnf_code": "0408010AEAAAIAI" } }, { "code": "42135011000001107", "description": "VMP subsequent to 415161007", "attributes": { "dmd_id": "42135011000001107", "dmd_type": "VMP", "bnf_code": "0408010AEAAADAD" } }, { "code": "42135111000001108", "description": "VMP subsequent to 415162000", "attributes": { "dmd_id": "42135111000001108", "dmd_type": "VMP", "bnf_code": "0408010AEAAAEAE" } }, { "code": "42135211000001102", "description": "VMP subsequent to 415163005", "attributes": { "dmd_id": "42135211000001102", "dmd_type": "VMP", "bnf_code": "0408010AEAAAFAF" } }, { "code": "42135311000001105", "description": "VMP subsequent to 421070002", "attributes": { "dmd_id": "42135311000001105", "dmd_type": "VMP", "bnf_code": "0408010AEAAAIAI" } }, { "code": "42135411000001103", "description": "VMP subsequent to 415164004", "attributes": { "dmd_id": "42135411000001103", "dmd_type": "VMP", "bnf_code": "0408010AEAAAAAA" } }, { "code": "42135511000001104", "description": "VMP subsequent to 415165003", "attributes": { "dmd_id": "42135511000001104", "dmd_type": "VMP", "bnf_code": "0408010AEAAAGAG" } }, { "code": "42135611000001100", "description": "VMP subsequent to 415166002", "attributes": { "dmd_id": "42135611000001100", "dmd_type": "VMP", "bnf_code": "0408010AEAAABAB" } }, { "code": "42135711000001109", "description": "VMP subsequent to 415167006", "attributes": { "dmd_id": "42135711000001109", "dmd_type": "VMP", "bnf_code": "0408010AEAAACAC" } }, { "code": "42137011000001100", "description": "VMP subsequent to 322956002", "attributes": { "dmd_id": "42137011000001100", "dmd_type": "VMP", "bnf_code": "0408010W0AAACAC" } }, { "code": "42137111000001104", "description": "VMP subsequent to 322957006", "attributes": { "dmd_id": "42137111000001104", "dmd_type": "VMP", "bnf_code": "0408010W0AAADAD" } }, { "code": "42137411000001109", "description": "VMP subsequent to 323024000", "attributes": { "dmd_id": "42137411000001109", "dmd_type": "VMP", "bnf_code": "040801050AAABAB" } }, { "code": "42137511000001108", "description": "VMP subsequent to 323025004", "attributes": { "dmd_id": "42137511000001108", "dmd_type": "VMP", "bnf_code": "040801050AAACAC" } }, { "code": "42137611000001107", "description": "VMP subsequent to 323029005", "attributes": { "dmd_id": "42137611000001107", "dmd_type": "VMP", "bnf_code": "040801050AAADAD" } }, { "code": "42137711000001103", "description": "VMP subsequent to 323023006", "attributes": { "dmd_id": "42137711000001103", "dmd_type": "VMP", "bnf_code": "040801050AAAAAA" } 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"4364511000001108", "dmd_type": "AMP", "bnf_code": "0404000R0BBABAC" } }, { "code": "4367611000001101", "description": "VMP previous to 407861004", "attributes": { "dmd_id": "4367611000001101", "dmd_type": "VMP", "bnf_code": "0404000R0AAACAC" } }, { "code": "448711000001102", "description": "Epilim 500 gastro-resistant tablets", "attributes": { "dmd_id": "448711000001102", "dmd_type": "AMP", "bnf_code": "0408010W0BBACAD" } }, { "code": "462911000001106", "description": "Sodium valproate 200mg gastro-resistant tablets", "attributes": { "dmd_id": "462911000001106", "dmd_type": "AMP", "bnf_code": "0408010W0AAACAC" } }, { "code": "4765911000001103", "description": "Epival CR 300mg tablets", "attributes": { "dmd_id": "4765911000001103", "dmd_type": "AMP", "bnf_code": "0408010W0BHAAA1" } }, { "code": "4766111000001107", "description": "Epival CR 500mg tablets", "attributes": { "dmd_id": "4766111000001107", "dmd_type": "AMP", "bnf_code": "0408010W0BHABA2" } }, { "code": "489711000001100", "description": "Epilim Chrono 200 tablets", "attributes": { "dmd_id": "489711000001100", "dmd_type": "AMP", "bnf_code": "0408010W0BBAJAZ" } }, { "code": "496811000001103", "description": "NeoMercazole 5 tablets", "attributes": { "dmd_id": "496811000001103", "dmd_type": "AMP", "bnf_code": "0602020D0BBAAAA" } }, { "code": "504711000001108", "description": "Orlept 200mg gastro-resistant tablets", "attributes": { "dmd_id": "504711000001108", "dmd_type": "AMP", "bnf_code": "0408010W0BEAAAC" } }, { "code": "534711000001104", "description": "Sodium valproate 200mg/5ml oral solution sugar free", "attributes": { "dmd_id": "534711000001104", "dmd_type": "AMP", "bnf_code": "0408010W0AAAAAA" } }, { "code": "552511000001100", "description": "Epilim 100mg crushable tablets", "attributes": { "dmd_id": "552511000001100", "dmd_type": "AMP", "bnf_code": "0408010W0BBAAAB" } }, { "code": "555011000001103", "description": "Sodium valproate 500mg gastro-resistant tablets", "attributes": { "dmd_id": 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"bnf_code": "0408010W0BBALA2" } }, { "code": "755011000001104", "description": "Sodium valproate 500mg gastro-resistant tablets", "attributes": { "dmd_id": "755011000001104", "dmd_type": "AMP", "bnf_code": "0408010W0AAADAD" } }, { "code": "757711000001108", "description": "Sodium valproate 200mg gastro-resistant tablets", "attributes": { "dmd_id": "757711000001108", "dmd_type": "AMP", "bnf_code": "0408010W0AAACAC" } }, { "code": "781611000001101", "description": "Sodium valproate 500mg gastro-resistant tablets", "attributes": { "dmd_id": "781611000001101", "dmd_type": "AMP", "bnf_code": "0408010W0AAADAD" } }, { "code": "7889411000001104", "description": "Lyrica 25mg capsules", "attributes": { "dmd_id": "7889411000001104", "dmd_type": "AMP", "bnf_code": "0408010AEBBAAAA" } }, { "code": "7890211000001109", "description": "Lyrica 50mg capsules", "attributes": { "dmd_id": "7890211000001109", "dmd_type": "AMP", "bnf_code": "0408010AEBBABAB" } }, { "code": "7890511000001107", "description": 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