[
  {
    "phenotype_id": "PH4090",
    "phenotype_version_id": 9308,
    "name": "Atrial fibrillation",
    "definition": "A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.\n\nUKB baseline self reported fields.\n",
    "implementation": "The earliest record across all sources is obtained.\n",
    "publications": [
      {
        "doi": "https://doi.org/10.1038/s41598-025-05838-9",
        "details": "Torralbo, Ana and Davitte, Jonathan M. and Croteau-Chonka, Damien C. and Ytsma, Cai R. and Tomlinson, Christopher and Fitzpatrick, Natalie and Chung, Sheng-Chia and Fatemifar, Ghazaleh and Cortes, Adrian S. and Richardson, Tom G. and Barclay, Matthew and Carrasco Zanini Sanchez, Julia and Finan, Chris and Hemingway, Harry and Hingorani, Aroon D. and Kuan Po Ai, Valerie and Langenberg, Claudia and Lyratzopoulos, Georgios and Lumbers, Tom and Pietzner, Maik and Shah, Anoop Dinesh and Thygesen, Johan Hilge and Zelenka, Natalie and Whittaker, John C. and Ehm, Margaret G. and Denaxas, Spiros, A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.",
        "primary": true
      }
    ],
    "validation": "Phenotypes underwent a multi\\-layered validation approach that included a) evaluating data source concordance, b) age\\-sex incidence and baseline prevalence patterns, c) an external comparison to a representative and unselected UK EHR dataset, d) modifiable risk factor associations, and e) genetic correlations with external genome\\-wide association studies (GWAS). Results showed consistent disease distributions by age and sex, high ranked correlation with general population prevalence estimates, confirmed risk factor associations, and significant genetic correlations with external GWAS.\n",
    "citation_requirements": null,
    "created": "2026-06-08T20:05:16.725591Z",
    "author": "Torralbo, A; Davitte, J M; Croteau-Chonka, D C; Ytsma, C; Tomlinson, C; Fitzpatrick, N K; Chung, S C; Fatemifar, G; Cortes, A S; Richardson, T G; Barclay, M; Carrasco Zanini, J; Finan, C; Hemingway, H; Hingorani, A; Kuan, V; Langenberg, C; Lyratzopoulos, G; Lumbers, R T; Pietzner, M; Shah, A D; Thygesen, J H; Zelenka, N; Whittaker, J C; Ehm, M G; Denaxas, S",
    "collections": [
      {
        "name": "Phenotype Library",
        "value": 18
      },
      {
        "name": "UK Biobank",
        "value": 32
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2026-06-08T20:05:16.717768Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "trials": null,
    "ontology": [
      {
        "name": "Atrial fibrillation (disorder)",
        "value": 611106
      }
    ],
    "phenoflowid": null,
    "data_sources": [
      {
        "name": "UK Biobank",
        "value": 13,
        "uid": "6a9f93ad-2434-41d9-93bf-6e9d2eee04e5",
        "url": "https://healthdatagateway.org/en/dataset/700",
        "datasource_id": 700
      },
      {
        "name": "Patient Episode Dataset for Wales (PEDW)",
        "value": 40,
        "uid": "4c33a5d2-164c-41d7-9797-dc2b008cc852",
        "url": "https://healthdatagateway.org/en/dataset/318",
        "datasource_id": 318
      },
      {
        "name": "Scottish Cancer Registry (SMR06)",
        "value": 417,
        "uid": "ad36dc03-1856-44de-99b0-1af6f312d86b",
        "url": "https://healthdatagateway.org/en/dataset/79",
        "datasource_id": 79
      },
      {
        "name": "Cancer Registration Data",
        "value": 788,
        "uid": "6904a2ff-ab44-4dd6-b9ec-25d3cad29e43",
        "url": "https://healthdatagateway.org/en/dataset/880",
        "datasource_id": 880
      }
    ],
    "endorsements": null,
    "project_name": null,
    "coding_system": [
      {
        "name": "UKBioBank codes",
        "value": 12
      },
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "Read codes v3",
        "value": 6
      }
    ],
    "corresp_author": "Ana Torralbo",
    "event_date_range": null,
    "concept_information": [
      {
        "concept_id": 9546,
        "concept_version_id": 17031,
        "concept_name": "Non-cancer illness code, self-reported",
        "coding_system": {
          "id": 12,
          "name": "UKBioBank codes",
          "description": "UKBioBank codes"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "1471",
            "description": "atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "1483",
            "description": "atrial flutter",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9547,
        "concept_version_id": 17032,
        "concept_name": "Diagnoses - main ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I48",
            "description": "Atrial fibrillation and flutter",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9548,
        "concept_version_id": 17033,
        "concept_name": "Diagnoses - secondary ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I48",
            "description": "Atrial fibrillation and flutter",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9549,
        "concept_version_id": 17034,
        "concept_name": "Underlying (primary) cause of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I48",
            "description": "Atrial fibrillation and flutter",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9550,
        "concept_version_id": 17035,
        "concept_name": "Contributory (secondary) causes of death: ICD10",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "I48",
            "description": "Atrial fibrillation and flutter",
            "attributes": {
              "type": "any"
            }
          }
        ]
      },
      {
        "concept_id": 9551,
        "concept_version_id": 17036,
        "concept_name": "GP clinical event records",
        "coding_system": {
          "id": 6,
          "name": "Read codes v3",
          "description": "Read codes v3"
        },
        "phenotype_id": "PH4090",
        "phenotype_version_id": 9308,
        "phenotype_name": "Atrial fibrillation",
        "code_attribute_header": [
          "type"
        ],
        "codes": [
          {
            "code": "14AN.00",
            "description": "H/O: atrial fibrillation",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "14AR.00",
            "description": "History of atrial flutter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "212R.00",
            "description": "Atrial fibrillation resolved",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "3272.00",
            "description": "ECG: atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "3273.00",
            "description": "ECG: atrial flutter",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "662S.00",
            "description": "Atrial fibrillation monitoring",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "6A9..00",
            "description": "Atrial fibrillation annual review",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9hF..00",
            "description": "Exception reporting: atrial fibrillation quality indicators",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9hF1.00",
            "description": "Excepted from atrial fibrillation qual indic: Inform dissent",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os..00",
            "description": "Atrial fibrillation monitoring administration",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os0.00",
            "description": "Atrial fibrillation monitoring first letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os1.00",
            "description": "Atrial fibrillation monitoring second letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os2.00",
            "description": "Atrial fibrillation monitoring third letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os3.00",
            "description": "Atrial fibrillation monitoring verbal invite",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "9Os4.00",
            "description": "Atrial fibrillation monitoring telephone invite",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "G573.00",
            "description": "Atrial fibrillation and flutter",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573000",
            "description": "Atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573100",
            "description": "Atrial flutter",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573200",
            "description": "Paroxysmal atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573300",
            "description": "Non-rheumatic atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573400",
            "description": "Permanent atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573500",
            "description": "Persistent atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "G573z00",
            "description": "Atrial fibrillation and flutter NOS",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "X202S",
            "description": "Non-rheumatic atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "Xa2E8",
            "description": "Paroxysmal atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaDv6",
            "description": "H/O: atrial fibrillation",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaIIT",
            "description": "Atrial fibrillation monitoring",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaLFh",
            "description": "Exception reporting: atrial fibrillation quality indicators",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaLFj",
            "description": "Excepted from atrial fibrillation quality indicators: Informed dissent",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaLFz",
            "description": "Atrial fibrillation resolved",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaMDF",
            "description": "Atrial fibrillation monitoring administration",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMDG",
            "description": "Atrial fibrillation monitoring first letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMDH",
            "description": "Atrial fibrillation monitoring second letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMDI",
            "description": "Atrial fibrillation monitoring third letter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMDK",
            "description": "Atrial fibrillation monitoring verbal invite",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMFn",
            "description": "Atrial fibrillation monitoring telephone invite",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaMGD",
            "description": "Atrial fibrillation annual review",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaNRA",
            "description": "History of atrial flutter",
            "attributes": {
              "type": "prevalent"
            }
          },
          {
            "code": "XaOfa",
            "description": "Persistent atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          },
          {
            "code": "XaOft",
            "description": "Permanent atrial fibrillation",
            "attributes": {
              "type": "any"
            }
          }
        ]
      }
    ],
    "status": 1,
    "doi": "https://doi.org/10.48533/d0ch-sc96",
    "is_deleted": false,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 2,
      "name": "BHF Data Science Centre Phenotype",
      "description": "BHF Data Science Centre Phenotype definitions that describe a list of clinical codes, algorithms using clinical codes, or set of clinical trials. Visit the BHF Data Science Centre website to learn more: https://bhfdatasciencecentre.org",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 9308,
        "version_name": "Atrial fibrillation",
        "version_date": "2026-06-08T20:05:16.738364Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]